{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:10:07Z","timestamp":1792656607022,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Using senescence-accelerated mouse prone 8 (SAMP8), we examined whether reduced mastication from a young age affects hippocampal-dependent cognitive function. We anesthetized male SAMP8 mice at 8 weeks of age and extracted all maxillary molar teeth of half the animals. The other animals were treated similarly, except that molar teeth were not extracted. At 12 and 24 weeks of age, their general behavior and their ability to recognize novel objects were tested using the open-field test (OFT) and the object-recognition test (ORT), respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The body weight of molarless mice was reduced significantly compared to that of molar-intact mice after the extraction and did not recover to the weight of age-matched molar-intact mice throughout the experimental period. At 12 weeks of age, molarless mice showed significantly greater locomotor activity in the OFT than molar-intact mice. However, the ability of molarless mice to discriminate a novel object in the ORT was impaired compared to that of molar-intact mice. The ability of both molarless and molar-intact SAMP8 mice to recognize objects was impaired at 24 weeks of age. These results suggest that molarless SAMP8 mice develop a deficit of cognitive function earlier than molar-intact SAMP8 mice. Interestingly, both at 12 and 24 weeks of age, molarless mice showed a lateralized preference of object location in the encoding session of the ORT, in which two identical objects were presented. Their lateralized preference of object location was positively correlated with the rightward turning-direction preference, which reached statistical significance at 24 weeks of age.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Loss of masticatory function in early life causes malnutrition and chronic stress and impairs the ability to recognize novel objects. Hyperactivation and lateralized rotational behavior are commonly observed with dysfunction of the dopaminergic system, therefore, reduced masticatory function may deplete the mesolimbic and mesocorticolimbic dopaminergic systems to impair the cognitive functions of selective attention and recognition memory in the prefrontal cortex and the hippocampus.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2202-15-4","type":"journal-article","created":{"date-parts":[[2014,1,4]],"date-time":"2014-01-04T22:01:07Z","timestamp":1388872867000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Loss of molars early in life develops behavioral lateralization and impairs hippocampus-dependent recognition memory"],"prefix":"10.1186","volume":"15","author":[{"given":"Masatsuna","family":"Kawahata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumie","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Kimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Onozuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,4]]},"reference":[{"issue":"4","key":"3456_CR1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/j.1741-2358.2005.00074.x","volume":"22","author":"H Miura","year":"2005","unstructured":"Miura H, Kariyasu M, Yamasaki K, Arai Y, Sumi Y: Relationship between general health status and the change in chewing ability: a longitudinal study of the frail elderly in Japan over a 3-year period. Gerodontology. 2005, 22 (4): 200-205. 10.1111\/j.1741-2358.2005.00074.x.","journal-title":"Gerodontology"},{"issue":"8","key":"3456_CR2","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1046\/j.1365-2842.2003.01124.x","volume":"30","author":"H Miura","year":"2003","unstructured":"Miura H, Yamasaki K, Kariyasu M, Miura K, Sumi Y: Relationship between cognitive function and mastication in elderly females. J Oral Rehabil. 2003, 30 (8): 808-811. 10.1046\/j.1365-2842.2003.01124.x.","journal-title":"J Oral Rehabil"},{"issue":"2","key":"3456_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1053\/j.sodo.2006.01.002","volume":"12","author":"PH Buschang","year":"2006","unstructured":"Buschang PH: Masticatory ability and performance: the effects of mutilated and maloccluded dentitions. Semin Orthod. 2006, 12 (2): 92-101. 10.1053\/j.sodo.2006.01.002.","journal-title":"Semin Orthod"},{"key":"3456_CR4","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.14219\/jada.archive.1998.0423","volume":"129","author":"E Krall","year":"1998","unstructured":"Krall E, Hayes G, Garcia R: How dentition status and masticatory function affect nutrient intake. J Am Dent Assoc. 1998, 129: 1261-1269.","journal-title":"J Am Dent Assoc"},{"issue":"6","key":"3456_CR5","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s12603-009-0097-7","volume":"13","author":"A Salva","year":"2009","unstructured":"Salva A, Coll-Planas L, Bruce S, De Groot L, Andrieu S, Abellan G, Vellas B, Andrieu S, Bartorelli L, Berner YN, Bruce S, Corman B, Domingo A, Egger TP, de Groot L, Guigoz Y, Imedio A, Planas M, Porras C, Rovira JC, Salv\u00e0 A, Serra JA, Vellas B, Task Force on Nutrition and Ageing of the IAGG and the IANA: Nutritional assessment of residents in long-term care facilities (LTCFs): recommendations of the task force on nutrition and ageing of the IAGG European region and the IANA. J Nutr Health Aging. 2009, 13 (6): 475-483. 10.1007\/s12603-009-0097-7.","journal-title":"J Nutr Health Aging"},{"issue":"2","key":"3456_CR6","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/cdoe.12000","volume":"41","author":"M Furuta","year":"2013","unstructured":"Furuta M, Komiya-Nonaka M, Akifusa S, Shimazaki Y, Adachi M, Kinoshita T, Kikutani T, Yamashita Y: Interrelationship of oral health status, swallowing function, nutritional status, and cognitive ability with activities of daily living in Japanese elderly people receiving home care services due to physical disabilities. Community Dent Oral Epidemiol. 2013, 41 (2): 173-181. 10.1111\/cdoe.12000.","journal-title":"Community Dent Oral Epidemiol"},{"key":"3456_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0300-9785(79)80024-1","volume":"8","author":"N von Wowern","year":"1979","unstructured":"von Wowern N, Hj\u00f8rting-Hansen E, Stoltze K: Changes in bone mass in rat mandibles after tooth extraction. Int J Oral Surg. 1979, 8: 229-233. 10.1016\/S0300-9785(79)80024-1.","journal-title":"Int J Oral Surg"},{"key":"3456_CR8","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.ajodo.2005.05.046","volume":"128","author":"H Sato","year":"2005","unstructured":"Sato H, Kawamura A, Yamaguchi M, Kasai K: Relationship between masticatory function and internal structure of the mandible based on computed tomography findings. Am J Orthod Dentofacial Orthop. 2005, 128: 766-773. 10.1016\/j.ajodo.2005.05.046.","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"3456_CR9","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1177\/00220345720510042801","volume":"51","author":"J Gyimesi","year":"1972","unstructured":"Gyimesi J, Zelles T: Effect of removal of molars on weight increase and food intake in albino rats. J Dent Res. 1972, 51: 897-899. 10.1177\/00220345720510042801.","journal-title":"J Dent Res"},{"key":"3456_CR10","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1177\/00220345740530053501","volume":"53","author":"J Gyimesi","year":"1974","unstructured":"Gyimesi J, Zelles T, Keszler P: Effect of experimental removal of molars on gastric and submaxillary salivary secretion in the rat. J Dent Res. 1974, 53: 1284-1288. 10.1177\/00220345740530053501.","journal-title":"J Dent Res"},{"key":"3456_CR11","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1679\/aohc.63.369","volume":"63","author":"T Muramoto","year":"2000","unstructured":"Muramoto T, Takano Y, Soma K: Time-related changes in periodontal mechanoreceptors in rat molars after the loss of occlusal stimuli. Arch Histol Cytol. 2000, 63: 369-380. 10.1679\/aohc.63.369.","journal-title":"Arch Histol Cytol"},{"issue":"1","key":"3456_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s12548-010-0047-3","volume":"3","author":"K Kato","year":"2010","unstructured":"Kato K, Ono Y, Kubo K-Y, Sasaguri K, Watanabe K, Onozuka M, Sato S: Occlusal disharmony suppresses long-term potentiation in the rat hippocampal CA1 region. International journal of stomatology & occlusion medicine. 2010, 3 (1): 71-75.","journal-title":"International journal of stomatology & occlusion medicine"},{"issue":"2","key":"3456_CR13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/10253890.2011.614296","volume":"15","author":"Y Ono","year":"2011","unstructured":"Ono Y, Lin HC, Tzen KY, Chen HH, Yang PF, Lai WS, Chen JH, Onozuka M, Yen CT: Active coping with stress suppresses glucose metabolism in the rat hypothalamus. Stress. 2011, 15 (2): 207-217.","journal-title":"Stress"},{"issue":"1","key":"3456_CR14","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0531-5565(00)00216-3","volume":"36","author":"K Watanabe","year":"2001","unstructured":"Watanabe K, Tonosaki K, Kawase T, Karasawa N, Nagatsu I, Fujita M, Onozuka M: Evidence for involvement of dysfunctional teeth in the senile process in the hippocampus of SAMP8 mice. Exp Gerontol. 2001, 36 (1): 283-295.","journal-title":"Exp Gerontol"},{"issue":"1","key":"3456_CR15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.brainres.2005.07.038","volume":"1057","author":"KY Kubo","year":"2005","unstructured":"Kubo KY, Iwaku F, Watanabe K, Fujita M, Onozuka M: Molarless-induced changes of spines in hippocampal region of SAMP8 mice. Brain Res. 2005, 1057 (1): 191-195.","journal-title":"Brain Res"},{"issue":"1","key":"3456_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0531-5565(96)00078-2","volume":"32","author":"M Hosokawa","year":"1997","unstructured":"Hosokawa M, Abe T, Higuchi K, Shimakawa K, Omori Y, Matsushita T, Kogishi K, Deguchi E, Kishimoto Y, Yasuoka K, Takeda T: Management and design of the maintenance of SAM mouse strains: an animal model for accelerated senescence and age-associated disorders. Exp Gerontol. 1997, 32 (1): 111-116.","journal-title":"Exp Gerontol"},{"issue":"1","key":"3456_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0166-4328(99)00145-X","volume":"108","author":"M Onozuka","year":"2000","unstructured":"Onozuka M, Watanabe K, Nagasaki S, Jiang Y, Ozono S, Nishiyama K, Kawase T, Karasawa N, Nagatsu I: Impairment of spatial memory and changes in astroglial responsiveness following loss of molar teeth in aged SAMP8 mice. Behav Brain Res. 2000, 108 (1): 145-155.","journal-title":"Behav Brain Res"},{"issue":"1","key":"3456_CR18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0166-4328(01)00378-3","volume":"131","author":"M Onozuka","year":"2002","unstructured":"Onozuka M, Watanabe K, Fujita M, Tonosaki K, Saito S: Evidence for involvement of glucocorticoid response in the hippocampal changes in aged molarless SAMP8 mice. Behav Brain Res. 2002, 131 (1): 125-129.","journal-title":"Behav Brain Res"},{"issue":"3","key":"3456_CR19","first-page":"165","volume":"25","author":"K Zwirska-Korczala","year":"1991","unstructured":"Zwirska-Korczala K, Ostrowska Z, Kucharzewski M, Marek B, Swietochowska E, Kos-Kud\u0142a B, Buntner B: Circadian variations of serum triiodothyronine, thyroxine, corticosterone and lipids in starved rats. Endocr Regul. 1991, 25 (3): 165-169.","journal-title":"Endocr Regul"},{"issue":"1","key":"3456_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0006-8993(83)90097-5","volume":"288","author":"C Nyakas","year":"1983","unstructured":"Nyakas C, De Kloet ER, Veldhuis HD, Bohus B: Hippocampal corticosterone receptors and novelty-induced behavioral activity: effect of kainic acid lesion in the hippocampus. Brain Res. 1983, 288 (1): 219-228.","journal-title":"Brain Res"},{"issue":"1","key":"3456_CR21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn849","volume":"3","author":"JJ Kim","year":"2002","unstructured":"Kim JJ, Diamond DM: The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci. 2002, 3 (1): 453-462.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"3456_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2220\/biomedres.28.1","volume":"28","author":"K Tsutsui","year":"2007","unstructured":"Tsutsui K, Kaku M, Motokawa M, Tohma Y, Kawata T, Fujita T, Kohno S, Ohtani J, Tenjoh K, Nakano M, Kamada H, Tanne K: Influences of reduced masticatory sensory input from soft-diet feeding upon spatial memory\/learning ability in mice. Biomed Res. 2007, 28 (1): 1-7. 10.2220\/biomedres.28.1.","journal-title":"Biomed Res"},{"issue":"7","key":"3456_CR23","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.neubiorev.2011.09.005","volume":"36","author":"JP Aggleton","year":"2012","unstructured":"Aggleton JP: Multiple anatomical systems embedded within the primate medial temporal lobe: implications for hippocampal function. Neurosci Biobehav Rev. 2012, 36 (7): 1579-1596. 10.1016\/j.neubiorev.2011.09.005.","journal-title":"Neurosci Biobehav Rev"},{"key":"3456_CR24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fncel.2013.00078","volume":"7","author":"RP Kesner","year":"2013","unstructured":"Kesner RP: A process analysis of the CA3 subregion of the hippocampus. Front Cell Neurosci. 2013, 7: 78-doi: 10.3389\/fncel.2013.00078","journal-title":"Front Cell Neurosci"},{"key":"3456_CR25","first-page":"379","volume-title":"Encyclopedia of stress","author":"MJ Meaney","year":"2000","unstructured":"Meaney MJ, Lupien S: Hippocampus, overview. Encyclopedia of stress. Edited by: Fink G. 2000, California: Academic Press, 379-386."},{"issue":"1","key":"3456_CR26","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neulet.2011.12.015","volume":"508","author":"A Ohno","year":"2012","unstructured":"Ohno A, Yoshino F, Yoshida A, Hori N, Ono Y, Kimoto K, Onozuka M, Lee MC: Soft-food diet induces oxidative stress in the rat brain. Neurosci Lett. 2012, 508 (1): 42-46. 10.1016\/j.neulet.2011.12.015.","journal-title":"Neurosci Lett"},{"issue":"1","key":"3456_CR27","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.neulet.2008.05.017","volume":"439","author":"S Kushida","year":"2008","unstructured":"Kushida S, Kimoto K, Hori N, Toyoda M, Karasawa N, Yamamoto T, Kojo A, Onozuka M: Soft-diet feeding decreases dopamine release and impairs aversion learning in Alzheimer model rats. Neurosci Lett. 2008, 439 (1): 208-211.","journal-title":"Neurosci Lett"},{"issue":"1","key":"3456_CR28","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.neuron.2005.05.002","volume":"46","author":"JE Lisman","year":"2005","unstructured":"Lisman JE, Grace AA: The hippocampal-VTA loop: controlling the entry of information into long-term memory. Neuron. 2005, 46 (1): 703-713.","journal-title":"Neuron"},{"issue":"1","key":"3456_CR29","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.pbb.2008.07.002","volume":"91","author":"K Mizoguchi","year":"2008","unstructured":"Mizoguchi K, Shoji H, Ikeda R, Tanaka Y, Tabira T: Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopaminergic neurotransmission. Pharmacol Biochem Behav. 2008, 91 (1): 170-175. 10.1016\/j.pbb.2008.07.002.","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"3456_CR30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11064-009-0026-5","volume":"35","author":"N Rasheed","year":"2010","unstructured":"Rasheed N, Ahmad A, Pandey CP, Chaturvedi RK, Lohani M, Palit L: Differential response of central dopaminergic system in acute and chronic unpredictable stress models in rats. Neurochem Res. 2010, 35 (1): 22-32. 10.1007\/s11064-009-0026-5.","journal-title":"Neurochem Res"},{"issue":"4","key":"3456_CR31","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1523\/JNEUROSCI.20-04-01568.2000","volume":"20","author":"K Mizoguchi","year":"2000","unstructured":"Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Chui DH, Tabira T: Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction. J Neurosci. 2000, 20 (4): 1568-1574.","journal-title":"J Neurosci"},{"issue":"1","key":"3456_CR32","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/0006-8993(93)90655-7","volume":"630","author":"JN Carlson","year":"1993","unstructured":"Carlson JN, Fitzgerald LW, Keller RW, Glick SD: Lateralized changes in prefrontal cortical dopamine activity induced by controllable and uncontrollable stress in the rat. Brain Res. 1993, 630 (1): 178-187.","journal-title":"Brain Res"},{"issue":"4","key":"3456_CR33","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0031-9384(96)00496-9","volume":"61","author":"DM Nielsen","year":"1997","unstructured":"Nielsen DM, Visker KE, Cunningham MJ, Keller RW, Glick SD, Carlson JN: Paw preference, rotation, and dopamine function in Collins HI and LO mouse strains. Physiol Behav. 1997, 61 (4): 525-535. 10.1016\/S0031-9384(96)00496-9.","journal-title":"Physiol Behav"},{"issue":"6","key":"3456_CR34","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/j.mehy.2007.10.013","volume":"70","author":"S Cortese","year":"2008","unstructured":"Cortese S, Lecendreux M, Bernardina BD, Mouren MC, Sbarbati A, Konofal E: Attention-deficit\/hyperactivity disorder, Tourette's syndrome, and restless legs syndrome: the iron hypothesis. Med Hypotheses. 2008, 70 (6): 1128-1132. 10.1016\/j.mehy.2007.10.013.","journal-title":"Med Hypotheses"},{"issue":"6","key":"3456_CR35","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/0031-9384(93)90382-P","volume":"53","author":"JG Kohlert","year":"1993","unstructured":"Kohlert JG, Bloch GJ: A rat model for attention deficit-hyperactivity disorder. Physiol Behav. 1993, 53 (6): 1215-1218. 10.1016\/0031-9384(93)90382-P.","journal-title":"Physiol Behav"},{"issue":"5","key":"3456_CR36","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/0031-9384(92)90084-F","volume":"51","author":"KS Bedi","year":"1992","unstructured":"Bedi KS: Spatial learning ability of rats undernourished during early postnatal life. Physiol Behav. 1992, 51 (5): 1001-1007. 10.1016\/0031-9384(92)90084-F.","journal-title":"Physiol Behav"},{"issue":"2","key":"3456_CR37","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0006-8993(01)02410-6","volume":"902","author":"T Yamamoto","year":"2001","unstructured":"Yamamoto T, Hirayama A: Effects of soft-diet feeding on synaptic density in the hippocampus and parietal cortex of senescence-accelerated mice. Brain Res. 2001, 902 (2): 255-263. 10.1016\/S0006-8993(01)02410-6.","journal-title":"Brain Res"},{"issue":"1","key":"3456_CR38","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.mcn.2008.06.009","volume":"39","author":"A Fontan-Lozano","year":"2008","unstructured":"Fontan-Lozano A, Romero-Granados R, Troncoso J, Munera A, Delgado-Garcia JM, Carrion AM: Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice. Mol Cell Neurosci. 2008, 39 (1): 193-201.","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"3456_CR39","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","volume":"31","author":"A Ennaceur","year":"1988","unstructured":"Ennaceur A, Delacour J: A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data. Behav Brain Res. 1988, 31 (1): 47-59. 10.1016\/0166-4328(88)90157-X.","journal-title":"Behav Brain Res"},{"issue":"1","key":"3456_CR40","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.psyneuen.2006.12.013","volume":"32","author":"B Aisa","year":"2007","unstructured":"Aisa B, Tordera R, Lasheras B, Del Rio J, Ramirez MJ: Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology. 2007, 32 (1): 256-266.","journal-title":"Psychoneuroendocrinology"}],"container-title":["BMC Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2202-15-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T02:28:37Z","timestamp":1630549717000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurosci.biomedcentral.com\/articles\/10.1186\/1471-2202-15-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,4]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["3456"],"URL":"https:\/\/doi.org\/10.1186\/1471-2202-15-4","relation":{},"ISSN":["1471-2202"],"issn-type":[{"value":"1471-2202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,4]]},"assertion":[{"value":"20 August 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"4"}}