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The present investigation was carried out to establish the protective effect of natansnin, a novel dibenzoyl glycoside from <jats:italic>Salvinia natans<\/jats:italic> against CCl<jats:sub>4<\/jats:sub> induced oxidative stress and cellular degeneration in rat liver.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>CCl<jats:sub>4<\/jats:sub> significantly increased the levels of lipid peroxides, oxidized glutathione and decreased the levels of reduced glutathione, SOD and CAT. CCl<jats:sub>4<\/jats:sub> induce marked histopathological changes and increase in the levels of apoptotic proteins. CCl<jats:sub>4<\/jats:sub> treatment significantly increased the levels of apoptotic proteins such as caspases-3, PARP, Bax, Bid and cytochrome C and also increased the levels of inflammatory mediators iNos and Cox-2. Natansnin treatment significantly decreased the levels of CCl<jats:sub>4<\/jats:sub> induced apoptotic proteins and inflammatory mediators. Further natansinin treatment significantly inhibited the CCl<jats:sub>4<\/jats:sub> induced apoptosis which was evident form the reduced TUNEL positive cells.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>In conclusion, our study demonstrated the protective effect of natansnin against CCl<jats:sub>4<\/jats:sub> induced oxidative stress and cellular degeneration in rat liver tissue. This protective effect of natansnin can be correlated to its direct antioxidant effect.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2210-10-13","type":"journal-article","created":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T15:46:46Z","timestamp":1335887206000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver"],"prefix":"10.1186","volume":"10","author":[{"given":"Polimetla","family":"Srilaxmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gangadhara Reddy","family":"Sareddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polavarapu Bilhan Kavi","family":"kishor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oruganti Hussainaiah","family":"Setty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phanithi Prakash","family":"Babu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,12]]},"reference":[{"key":"726_CR1","volume-title":"Herbal harvests with a future: towards sustainable sources for medicinal plants, Plantlife International","author":"G Vines","year":"2004","unstructured":"Vines G: Herbal harvests with a future: towards sustainable sources for medicinal plants, Plantlife International. 2004, [http:\/\/www.Plantlife.Org.uk]"},{"key":"726_CR2","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s10600-005-0189-5","volume":"41","author":"OA Rozentsvet","year":"2005","unstructured":"Rozentsvet OA, Rezanka T, Bosenko ES, Uzhametskaya EA, Dembitskii VM: Fatty acids, phospholipids, and the betaine lipid dgts from the aquatic fern Salvinia natans. 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