{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:58:23Z","timestamp":1761541103487},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Although the heritability of atrial fibrillation (AF) has been determined, the relevance of family history of AF for the likelihood of recurrent hospitalization for AF is unknown. The aim of this nationwide study was to determine whether family history of AF is a risk factor of recurrent hospitalization for lone AF (LAF), i.e., AF with unknown etiology. The familial risk for first time LAF hospitalization was also determined and compared to the risk of recurrent hospitalization for LAF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We examined whether family history of AF is a risk factor for recurrent hospitalization for LAF in the whole Swedish population. We linked Multigeneration Register data on individuals aged 0\u201360 years to Hospital Discharge Register data for the period 1987\u20132009 to compare LAF recurrent hospitalization risk among individuals with and without parental or sibling history of AF. We calculated hazard ratios (HRs) to determine the familial HR of recurrent hospitalization for LAF. Odds ratios (OR) were calculated for familial risk of first time LAF hospitalization.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The risk of recurrent LAF hospitalization was 1.23 (95% CI 1.17-1.30) for individuals with affected parents compared to 1.30 (95% CI 1.22-1.38) for those with affected siblings. After 10 years of follow up 50% of those without and 60% of those with family history had recurrent hospitalization for LAF. The risk of recurrent LAF hospitalization in individuals with two affected parents was 1.65 (95% CI 1.44-1.90). There was an interaction between age and family history, with family history having a weaker effect on LAF hospitalization risk in older age groups. The OR for first time LAF hospitalization was 2.08 (95% CI 2.02-2.15) for offspring with affected parents and 3.23 (95% CI 3.08-3.39) for individuals with affected siblings.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Family history of AF is a novel risk factor for recurrent LAF hospitalization. The higher recurrence hospitalization risk in multiplex families and younger individuals suggests a genetic contribution. However, the familial risk for recurrent LAF hospitalization was much lower than the risk for first time LAF hospitalization, suggesting that familial and possibly genetic factors are more important for first time LAF hospitalization than recurrent LAF hospitalization.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2261-12-121","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T21:14:19Z","timestamp":1355174059000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden"],"prefix":"10.1186","volume":"12","author":[{"given":"Bengt","family":"Z\u00f6ller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Ohlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"525_CR1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1161\/CIR.0b013e318224b037","volume":"124","author":"NA Estes 3rd","year":"2011","unstructured":"Estes NA, Sacco RL, Al-Khatib SM, Ellinor PT, Bezanson J, Alonso A, Antzelevitch C, Brockman RG, Chen PS, Chugh SS, Curtis AB, DiMarco JP, Ellenbogen KA, Epstein AE, Ezekowitz MD, Fayad P, Gage BF, Go AS, Hlatky MA, Hylek EM, Jerosch-Herold M, Konstam MA, Lee R, Packer DL, Po SS, Prystowsky EN, Redline S, Rosenberg Y, Van Wagoner DR, Wood KA, et al: American Heart Association atrial fibrillation research summit: a conference report from the American Heart Association. Circulation. 2011, 124: 363-372. 10.1161\/CIR.0b013e318224b037.","journal-title":"Circulation"},{"key":"525_CR2","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/S0140-6736(11)61514-6","volume":"379","author":"GY Lip","year":"2012","unstructured":"Lip GY, Tse HF, Lane DA: Atrial fibrillation. Lancet. 2012, 379: 648-661. 10.1016\/S0140-6736(11)61514-6.","journal-title":"Lancet"},{"key":"525_CR3","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/europace\/eun124","volume":"10","author":"BA Schoonderwoerd","year":"2008","unstructured":"Schoonderwoerd BA, Smit MD, Pen L, Van Gelder IC: New risk factors for atrial fibrillation: causes of \u2018not-so-lone atrial fibrillation\u2019. Europace. 2008, 10: 668-673. 10.1093\/europace\/eun124.","journal-title":"Europace"},{"key":"525_CR4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1136\/hrt.16.2.189","volume":"16","author":"W Evans","year":"1954","unstructured":"Evans W, Swann P: Lone auricular fibrillation. Br Heart J. 1954, 16: 189-194. 10.1136\/hrt.16.2.189.","journal-title":"Br Heart J"},{"key":"525_CR5","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/j.1742-1241.2010.02618.x","volume":"65","author":"TS Potpara","year":"2011","unstructured":"Potpara TS, Lip GY: Lone atrial fibrillation: what is known and what is to come. Int J Clin Pract. 2011, 65: 446-457. 10.1111\/j.1742-1241.2010.02618.x.","journal-title":"Int J Clin Pract"},{"key":"525_CR6","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1056\/NEJM194309022291002","volume":"229","author":"L Wolf","year":"1943","unstructured":"Wolf L: Familial auricular fibrillation. N Engl J Med. 1943, 229: 396-397. 10.1056\/NEJM194309022291002.","journal-title":"N Engl J Med"},{"key":"525_CR7","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1016\/S0735-1097(03)00465-0","volume":"41","author":"D Darbar","year":"2003","unstructured":"Darbar D, Herron KJ, Ballew JD, Jahangir A, Gersh BJ, Shen WK, Hammill SC, Packer DL, Olson TM: Familial atrial fibrillation is a genetically heterogeneous disorder. J Am Coll Cardiol. 2003, 41: 2185-2192. 10.1016\/S0735-1097(03)00465-0.","journal-title":"J Am Coll Cardiol"},{"key":"525_CR8","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1001\/jama.291.23.2851","volume":"291","author":"CS Fox","year":"2004","unstructured":"Fox CS, Parise H, D\u2019Agostino RB, Lloyd-Jones DM, Vasan RS, Wang TJ, Levy D, Wolf PA, Benjamin EJ: Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA. 2004, 291: 2851-2855. 10.1001\/jama.291.23.2851.","journal-title":"JAMA"},{"key":"525_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00439-005-0034-8","volume":"118","author":"PT Ellinor","year":"2005","unstructured":"Ellinor PT, Yoerger DM, Ruskin JN, MacRae CA: Familial aggregation in lone atrial fibrillation. Hum Genet. 2005, 118: 179-184. 10.1007\/s00439-005-0034-8.","journal-title":"Hum Genet"},{"key":"525_CR10","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1093\/eurheartj\/ehi727","volume":"27","author":"DO Arnar","year":"2006","unstructured":"Arnar DO, Thorvaldsson S, Manolio TA, Thorgeirsson G, Kristjansson K, Hakonarson H, Stefansson K: Familial aggregation of atrial fibrillation in Iceland. Eur Heart J. 2006, 27: 708-712. 10.1093\/eurheartj\/ehi727.","journal-title":"Eur Heart J"},{"key":"525_CR11","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.hrthm.2008.02.016","volume":"5","author":"GM Marcus","year":"2008","unstructured":"Marcus GM, Smith LM, Vittinghoff E, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE: A first-degree family history in lone atrial fibrillation patients. Hear Rhythm. 2008, 5: 826-830. 10.1016\/j.hrthm.2008.02.016.","journal-title":"Hear Rhythm"},{"key":"525_CR12","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1111\/j.1540-8167.2008.01126.x","volume":"19","author":"LY Chen","year":"2008","unstructured":"Chen LY, Herron KJ, Tai BC, Olson TM: Lone atrial fibrillation: influence of familial disease on gender predilection. J Cardiovasc Electrophysiol. 2008, 19: 802-806. 10.1111\/j.1540-8167.2008.01126.x.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"525_CR13","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1161\/CIRCEP.108.786665","volume":"2","author":"IE Christophersen","year":"2009","unstructured":"Christophersen IE, Ravn LS, Budtz-Joergensen E, Skytthe A, Haunsoe S, Svendsen JH, Christensen K: Familial aggregation of atrial fibrillation: a study in Danish twins. Circ Arrhythm Electrophysiol. 2009, 2: 378-383. 10.1161\/CIRCEP.108.786665.","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"525_CR14","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.2169\/internalmedicine.49.4130","volume":"49","author":"YQ Yang","year":"2010","unstructured":"Yang YQ, Zhang XL, Wang XH, Tan HW, Shi HF, Fang WY, Liu X: Familial aggregation of lone atrial fibrillation in the Chinese population. Intern Med. 2010, 49: 2385-2391. 10.2169\/internalmedicine.49.4130.","journal-title":"Intern Med"},{"key":"525_CR15","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1001\/jama.2010.1690","volume":"304","author":"SA Lubitz","year":"2010","unstructured":"Lubitz SA, Yin X, Fontes JD, Magnani JW, Rienstra M, Pai M, Villalon ML, Vasan RS, Pencina MJ, Levy D, Larson MG, Ellinor PT, Benjamin EJ: Association between familial atrial fibrillation and risk of new-onset atrial fibrillation. JAMA. 2010, 304: 2263-2269. 10.1001\/jama.2010.1690.","journal-title":"JAMA"},{"key":"525_CR16","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1056\/NEJM199703273361302","volume":"336","author":"R Brugada","year":"1997","unstructured":"Brugada R, Tapscott T, Czernuszewicz G, Marian AJ, Iglesias A, Mont L, Brugada J, Girona J, Domingo A, Bachinski LL, Roberts R: Identification of a genetic locus for familial atrial fibrillation. N Engl J Med. 1997, 336: 905-911. 10.1056\/NEJM199703273361302.","journal-title":"N Engl J Med"},{"key":"525_CR17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nature06007","volume":"448","author":"DF Gudbjartsson","year":"2007","unstructured":"Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, Sigurdsson A, Jonasdottir A, Baker A, Thorleifsson G, Kristjansson K, Palsson A, Blondal T, Sulem P, Backman VM, Hardarson GA, Palsdottir E, Helgason A, Sigurjonsdottir R, Sverrisson JT, Kostulas K, Ng MC, Baum L, So WY, Wong KS, Chan JC, Furie KL, Greenberg SM, Sale M, Kelly P, MacRae CA, et al: Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature. 2007, 448: 353-357. 10.1038\/nature06007.","journal-title":"Nature"},{"key":"525_CR18","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/ng.417","volume":"41","author":"DF Gudbjartsson","year":"2009","unstructured":"Gudbjartsson DF, Holm H, Gretarsdottir S, Thorleifsson G, Walters GB, Thorgeirsson G, Gulcher J, Mathiesen EB, Nj\u00f8lstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Kucera G, Stubblefield T, Carter S, Roden D, Ng MC, Baum L, So WY, Wong KS, Chan JC, Gieger C, Wichmann HE, Gschwendtner A, Dichgans M, Kuhlenb\u00e4umer G, Berger K, Ringelstein EB, et al: A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Nat Genet. 2009, 41: 876-878. 10.1038\/ng.417.","journal-title":"Nat Genet"},{"key":"525_CR19","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/ng.416","volume":"41","author":"EJ Benjamin","year":"2009","unstructured":"Benjamin EJ, Rice KM, Arking DE, Pfeufer A, van Noord C, Smith AV, Schnabel RB, Bis JC, Boerwinkle E, Sinner MF, Dehghan A, Lubitz SA, D'Agostino RB, Lumley T, Ehret GB, Heeringa J, Aspelund T, Newton-Cheh C, Larson MG, Marciante KD, Soliman EZ, Rivadeneira F, Wang TJ, Eir\u00edksdottir G, Levy D, Psaty BM, Li M, Chamberlain AM, Hofman A, Vasan RS, et al: Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet. 2009, 41: 879-881. 10.1038\/ng.416.","journal-title":"Nat Genet"},{"key":"525_CR20","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/ng.537","volume":"42","author":"PT Ellinor","year":"2010","unstructured":"Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA, Fox E, Darbar D, Smith NL, Smith JD, Schnabel RB, Soliman EZ, Rice KM, Van Wagoner DR, Beckmann BM, van Noord C, Wang K, Ehret GB, Rotter JI, Hazen SL, Steinbeck G, Smith AV, Launer LJ, Harris TB, Makino S, Nelis M, et al: Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet. 2010, 42: 240-244. 10.1038\/ng.537.","journal-title":"Nat Genet"},{"key":"525_CR21","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1172\/JCI46315","volume":"121","author":"R Wakili","year":"2011","unstructured":"Wakili R, Voigt N, K\u00e4\u00e4b S, Dobrev D, Nattel S: Recent advances in the molecular pathophysiology of atrial fibrillation. J Clin Invest. 2011, 121: 2955-2968. 10.1172\/JCI46315.","journal-title":"J Clin Invest"},{"key":"525_CR22","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.jelectrocard.2011.07.027","volume":"44","author":"B Parvez","year":"2011","unstructured":"Parvez B, Darbar D: The \u201cmissing link\u201d in atrial fibrillation heritability. J Electrocardiol. 2011, 44: 641-644. 10.1016\/j.jelectrocard.2011.07.027.","journal-title":"J Electrocardiol"},{"key":"525_CR23","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1093\/cvr\/cvq348","volume":"89","author":"MS Olesen","year":"2011","unstructured":"Olesen MS, Jespersen T, Nielsen JB, Liang B, M\u00f8ller DV, Hedley P, Christiansen M, Varr\u00f3 A, Olesen SP, Hauns\u00f8 S, Schmitt N, Svendsen JH: Mutations in sodium channel \u03b2-subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc Res. 2011, 89: 786-793. 10.1093\/cvr\/cvq348.","journal-title":"Cardiovasc Res"},{"key":"525_CR24","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1161\/CIRCEP.108.779181","volume":"2","author":"H Watanabe","year":"2009","unstructured":"Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM: Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol. 2009, 2: 268-275. 10.1161\/CIRCEP.108.779181.","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"525_CR25","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/ng.2261","volume":"44","author":"PT Ellinor","year":"2012","unstructured":"Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, M\u00fcller-Nurasyid M, Krijthe BP, Lubitz SA, Bis JC, Chung MK, D\u00f6rr M, Ozaki K, Roberts JD, Smith JG, Pfeufer A, Sinner MF, Lohman K, Ding J, Smith NL, Smith JD, Rienstra M, Rice KM, Van Wagoner DR, Magnani JW, Wakili R, Clauss S, Rotter JI, Steinbeck G, et al: Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet. 2012, 44: 670-675. 10.1038\/ng.2261.","journal-title":"Nat Genet"},{"key":"525_CR26","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/j.jacc.2006.12.042","volume":"49","author":"T Liu","year":"2007","unstructured":"Liu T, Li G, Li L, Korantzopoulos P: Association between C-reactive protein and recurrence of atrial fibrillation after successful electrical cardioversion: a meta-analysis. J Am Coll Cardiol. 2007, 49: 1642-1648. 10.1016\/j.jacc.2006.12.042.","journal-title":"J Am Coll Cardiol"},{"issue":"155","key":"525_CR27","first-page":"9","volume":"152","author":"OT Gurevitz","year":"2006","unstructured":"Gurevitz OT, Varadachari CJ, Ammash NM, Malouf JF, Rosales AG, Herges RM, Bruce CJ, Somers VK, Hammill SC, Gersh BJ, Friedman PA: The effect of patient sex on recurrence of atrial fibrillation following successful direct current cardioversion. Am Heart J. 2006, 152 (155): 9-13.","journal-title":"Am Heart J"},{"key":"525_CR28","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.amjcard.2010.10.018","volume":"107","author":"M Guglin","year":"2011","unstructured":"Guglin M, Maradia K, Chen R, Curtis AB: Relation of obesity to recurrence rate and burden of atrial fibrillation. Am J Cardiol. 2011, 107: 579-582. 10.1016\/j.amjcard.2010.10.018.","journal-title":"Am J Cardiol"},{"key":"525_CR29","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.ahj.2010.02.016","volume":"159","author":"M Disertori","year":"2010","unstructured":"Disertori M, Lombardi F, Barlera S, Latini R, Maggioni AP, Zeni P, Di Pasquale G, Cosmi F, Franzosi MG, GISSI-AF Investigators: Clinical predictors of atrial fibrillation recurrence in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Atrial Fibrillation (GISSI-AF) trial. Am Heart J. 2010, 159: 857-863. 10.1016\/j.ahj.2010.02.016.","journal-title":"Am Heart J"},{"key":"525_CR30","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.amjcard.2009.09.037","volume":"105","author":"M Schmidt","year":"2010","unstructured":"Schmidt M, Rieber J, Daccarett M, Marschang H, Sinha AM, Biggar P, Jung P, Ketteler M, Brachmann J, Rittger H: Relation of recurrence of atrial fibrillation after successful cardioversion to renal function. Am J Cardiol. 2010, 105: 368-372. 10.1016\/j.amjcard.2009.09.037.","journal-title":"Am J Cardiol"},{"key":"525_CR31","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1365-2796.2010.02287.x","volume":"269","author":"R Latini","year":"2011","unstructured":"Latini R, Masson S, Pirelli S, Barlera S, Pulitano G, Carbonieri E, Gulizia M, Vago T, Favero C, Zdunek D, Struck J, Staszewsky L, Maggioni AP, Franzosi MG, Disertori M, on the behalf of the GISSI-AF Investigators: Circulating cardiovascular biomarkers in recurrent atrial fibrillation: data from the GISSI-atrial fibrillation trial. J Intern Med. 2011, 269: 160-171. 10.1111\/j.1365-2796.2010.02287.x.","journal-title":"J Intern Med"},{"key":"525_CR32","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1177\/147323001103900504","volume":"39","author":"Y Tang","year":"2011","unstructured":"Tang Y, Yang H, Qiu J: Relationship between brain natriuretic peptide and recurrence of atrial fibrillation after successful electrical cardioversion: a meta-analysis. J Int Med Res. 2011, 39: 1618-1624.","journal-title":"J Int Med Res"},{"key":"525_CR33","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/978-3-540-26577-1_5","volume-title":"Handbook of epidemiology","author":"M Rosen","year":"2005","unstructured":"Rosen M, Hakulinen T: Use of disease registers. Handbook of epidemiology. Edited by: Ahrens W, Pigeot I. 2005, Springer-Verlag: Berlin, 231-252."},{"key":"525_CR34","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/S0140-6736(09)60072-6","volume":"373","author":"P Lichtenstein","year":"2009","unstructured":"Lichtenstein P, Yip BH, Bj\u00f6rk C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CH: Common genetics determinants of schizophrenia and bipolar disorders in Swedish families: a population-based study. Lancet. 2009, 373: 234-239. 10.1016\/S0140-6736(09)60072-6.","journal-title":"Lancet"},{"key":"525_CR35","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1161\/CIRCGENETICS.111.959882","volume":"4","author":"B Z\u00f6ller","year":"2011","unstructured":"Z\u00f6ller B, Li X, Ohlsson H, Sundquist J, Sundquist K: Venous thromboembolism does not share strong familial susceptibility with ischemic stroke: a nationwide family study in Sweden. Circ Cardiovasc Genet. 2011, 4: 484-490. 10.1161\/CIRCGENETICS.111.959882.","journal-title":"Circ Cardiovasc Genet"},{"key":"525_CR36","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1161\/CIRCULATIONAHA.110.965020","volume":"124","author":"B Z\u00f6ller","year":"2011","unstructured":"Z\u00f6ller B, Li X, Sundquist J, Sundquist K: Age- and gender-specific familial risks for venous thromboembolism: a nationwide epidemiological study based on hospitalizations in Sweden. Circulation. 2011, 124: 1012-1020. 10.1161\/CIRCULATIONAHA.110.965020.","journal-title":"Circulation"},{"key":"525_CR37","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1186\/1471-2458-11-450","volume":"11","author":"JF Ludvigsson","year":"2011","unstructured":"Ludvigsson JF, Andersson E, Ekbom A, Feychting M, Kim JL, Reuterwall C, Heurgren M, Olausson PO: External review and validation of the Swedish national inpatient register. BMC Publ Health. 2011, 11: 450-10.1186\/1471-2458-11-450.","journal-title":"BMC Publ Health"},{"key":"525_CR38","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10654-009-9404-1","volume":"25","author":"JG Smith","year":"2010","unstructured":"Smith JG, Platonov PG, Hedblad B, Engstr\u00f6m G, Melander O: Atrial fibrillation in the Malm\u00f6 Diet and Cancer study: a study of occurrence, risk factors and diagnostic validity. Eur J Epidemiol. 2010, 25: 95-102. 10.1007\/s10654-009-9404-1.","journal-title":"Eur J Epidemiol"},{"key":"525_CR39","volume-title":"Modern Epidemiology","author":"K Rothman","year":"2008","unstructured":"Rothman K, Greenland S: Modern Epidemiology. 2008, Philadelphia: Lippincott-Raven, 3","edition":"3"},{"key":"525_CR40","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/S0140-6736(05)67322-9","volume":"366","author":"PR Burton","year":"2005","unstructured":"Burton PR, Tobin MD, Hopper JL: Key concepts in genetic epidemiology. Lancet. 2005, 366: 941-951. 10.1016\/S0140-6736(05)67322-9.","journal-title":"Lancet"},{"key":"525_CR41","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1093\/carcin\/bgl182","volume":"28","author":"K Hemminki","year":"2007","unstructured":"Hemminki K, Bermejo JL: Constraints for genetic association studies imposed by attributable fraction and familial risks. Carcinogenesis. 2007, 28: 648-656.","journal-title":"Carcinogenesis"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2261-12-121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2261-12-121\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2261-12-121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2261-12-121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T20:54:44Z","timestamp":1630529684000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/1471-2261-12-121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["525"],"URL":"https:\/\/doi.org\/10.1186\/1471-2261-12-121","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"3 July 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"121"}}