{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:40:28Z","timestamp":1790059228833,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular diseases. The role of the alpha7 nicotinic acetylcholine receptor (\u03b17nAChR) in inflammation has recently been identified. Our previous study has demonstrated that the \u03b17nAChR-mediated cholinergic anti-inflammatory pathway is impaired systemically in the genetic model of hypertension. In this work, we investigated the changes of \u03b17nAChR expression in a model of secondary hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The 2-kidney 1-clip (2K1C) hypertensive rat model was used. Blood pressure, vagus nerve function, serum tumor necrosis factor-\u03b1 (TNF-\u03b1) and both the mRNA and protein levels of \u03b17nAChR in tissues from heart, kidney and aorta were measured at 4, 8 and 20 weeks after surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Compared with age-matched control, it was found that vagus nerve function was significantly decreased in 2K1C rats with the development of hypertension. Serum levels of TNF-\u03b1 were greater in 2K1C rats than in age-matched control at 4, 8 and 20 weeks. \u03b17nAChR mRNA in the heart was not altered in 2K1C rats. In the kidney of 2K1C rats, \u03b17nAChR expression was significantly decreased at 8 and 20 weeks, but markedly increased at 4 weeks. \u03b17nAChR mRNA was less in aorta of 2K1C rats than in age-matched control at 4, 8 and 20 weeks. These findings were confirmed at the protein levels of \u03b17nAChR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our results suggested that secondary hypertension may induce \u03b17nAChR downregulation, and the decreased expression of \u03b17nAChR may contribute to inflammation in 2K1C hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2261-12-38","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T11:59:24Z","timestamp":1339588764000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats"],"prefix":"10.1186","volume":"12","author":[{"given":"Ji-Kuai","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Ming","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,6,8]]},"reference":[{"key":"499_CR1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1291\/hypres.27.193","volume":"27","author":"M Omura","year":"2004","unstructured":"Omura M, Saito J, Yamaguchi K, Kakuta Y, Nishikawa T: Prospective study on the prevalence of secondary hypertension among hypertensive patients visiting a general outpatient clinic in Japan. 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