{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:05:53Z","timestamp":1792148753757,"version":"4.4.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T00:00:00Z","timestamp":1144713600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Emerg Med"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Methylene bis(thiocyanate) (MBT) is a microbiocidal agent mainly used in industrial water cooling systems and paper mills as an inhibitor of algae, fungi, and bacteria.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>We describe the first case of severe intoxication following inhalation of powder in an industrial worker. Profound cyanosis and respiratory failure caused by severe methemoglobinemia developed within several minutes. Despite immediate admission to the intensive care unit, where mechanical ventilation and hemodialysis for toxin elimination were initiated, multi-organ failure involving liver, kidneys, and lungs developed. While liver failure was leading, the patient was successfully treated with the MARS (molecular adsorbent recirculating system) procedure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Intoxication with MBT is a potentially life-threatening intoxication causing severe methemoglobinemia and multi-organ failure. Extracorporeal liver albumin dialysis (MARS) appears to be an effective treatment to allow recovery of hepatic function.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-227x-6-5","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T14:36:15Z","timestamp":1145543775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Life-threatening intoxication with methylene bis(thiocyanate): clinical picture and pitfalls. A case report"],"prefix":"10.1186","volume":"6","author":[{"given":"Claude","family":"Braun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Birck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred V","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schnuelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fokko J","family":"van der Woude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"L\u00f6hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,4,11]]},"reference":[{"key":"25_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1053\/lv.2000.6355","volume":"6","author":"SR Mitzner","year":"2000","unstructured":"Mitzner SR, Stange J, Klammt S, Risler T, Erley CM, Bader BD, Berger ED, Lauchart W, Peszynski P, Freytag J, Hickstein H, Loock J, L\u00f6hr JM, Liebe S, Emmrich J, Korten G, Schmidt R: Improvement of hepatorenal syndrome with extracorporeal albumin dialysis MARS: results of a prospective, randomized, controlled clinical trial. Liver Transpl. 2000, 6: 277-286. 10.1053\/lv.2000.6355.","journal-title":"Liver Transpl"},{"issue":"Suppl 2","key":"25_CR2","first-page":"20","volume":"22","author":"C Steiner","year":"2002","unstructured":"Steiner C, Mitzner S: Experiences with MARS liver support therapy in liver failure: analysis of 176 patients of the International MARS Registry. Liver. 2002, 22 (Suppl 2): 20-25.","journal-title":"Liver"},{"key":"25_CR3","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1053\/jhep.2002.36130","volume":"36","author":"U Heemann","year":"2002","unstructured":"Heemann U, Treichel U, Loock J, Philipp T, Gerken G, Malago M, Klammt S, Loehr M, Liebe S, Mitzner S, Schmidt R, Stange J: Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective, controlled study. Hepatology. 2002, 36: 949-958.","journal-title":"Hepatology"},{"key":"25_CR4","first-page":"5","volume":"25","author":"K Jeevaratnam","year":"1993","unstructured":"Jeevaratnam K: Systemic toxicity of methyl isocyanate in mammals. Indian Journal of Pharmacology. 1993, 25: 5-13.","journal-title":"Indian Journal of Pharmacology"},{"key":"25_CR5","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1001\/jama.1990.03450210081037","volume":"264","author":"PS Mehta","year":"1990","unstructured":"Mehta PS, Mehta AS, Mehta SJ, Makhijani AB: Bhopal tragedy's health effects. A review of methyl isocyanate toxicity. JAMA. 1990, 264: 2781-2787. 10.1001\/jama.264.21.2781.","journal-title":"JAMA"},{"key":"25_CR6","unstructured":"National Institute for Occupational Safety and Health (NIOSH). International Chemical Safety Cards. [http:\/\/www.cdc.gov\/niosh\/ipcsneng\/neng1287.html]"},{"key":"25_CR7","unstructured":"United States Environmental Protection Agency. Reregistration eligibility decision (RED) methylene bis(thiocyanate). [http:\/\/www.epa.gov\/oppsrrd1\/REDs\/2415red.pdf]"},{"key":"25_CR8","unstructured":"Output Reporting USEPA\/OPP Chemical Information: Methylene bis(thiocyanate) active products. [http:\/\/www.cdpr.ca.gov\/cgi-bin\/epa]"},{"key":"25_CR9","unstructured":"TOXNET National Library of Medicine Specialized Information Services: Methylene bis(thiocyanate). [http:\/\/www.toxnet.nlm.nih.gov]"},{"key":"25_CR10","first-page":"1","volume":"32","author":"LT Burka","year":"1993","unstructured":"Burka LT: NTP technical report on the toxicity studies of Methylene Bis (thiocyanate) (CAS No. 6317-18-6) administered by gavage to F344\/N rats and B6C3F1 mice. Toxic Rep Ser. 1993, 32: 1-E7.","journal-title":"Toxic Rep Ser"},{"key":"25_CR11","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/ndt\/17.2.316","volume":"17","author":"CW McIntyre","year":"2002","unstructured":"McIntyre CW, Fluck RJ, Freeman JG, Lambie SH: Use of albumin dialysis in the treatment of hepatic and renal dysfunction due to paracetamol intoxication. Nephrol Dial Transplant. 2002, 17: 316-317. 10.1093\/ndt\/17.2.316.","journal-title":"Nephrol Dial Transplant"},{"issue":"Suppl 2","key":"25_CR12","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1034\/j.1600-0676.2002.00016.x","volume":"22","author":"S Prokurat","year":"2002","unstructured":"Prokurat S, Grenda R, Lipowski D, Kalicinski P, Migdal M: MARS procedure as a bridge to combined liver-kidney transplantation in severe chromium-copper acute intoxication: a paediatric case report. Liver. 2002, 22 (Suppl 2): 76-77.","journal-title":"Liver"},{"issue":"Suppl 2","key":"25_CR13","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1034\/j.1600-0676.2002.00017.x","volume":"22","author":"Y Shi","year":"2002","unstructured":"Shi Y, He J, Chen S, Zhang L, Yang X, Wang Z, Wang M: MARS: optimistic therapy method in fulminant hepatic failure secondary to cytotoxic mushroom poisoning \u2013 a case report. Liver. 2002, 22 (Suppl 2): 78-80.","journal-title":"Liver"}],"container-title":["BMC Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-227X-6-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-227X-6-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-227X-6-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-227X-6-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T21:28:14Z","timestamp":1630445294000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcemergmed.biomedcentral.com\/articles\/10.1186\/1471-227X-6-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,11]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["25"],"URL":"https:\/\/doi.org\/10.1186\/1471-227x-6-5","relation":{},"ISSN":["1471-227X"],"issn-type":[{"value":"1471-227X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,11]]},"assertion":[{"value":"27 June 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"5"}}