{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:22:36Z","timestamp":1782177756048,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T00:00:00Z","timestamp":1245715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Med Res Methodol"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1186\/1471-2288-9-41","type":"journal-article","created":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T09:49:17Z","timestamp":1249638557000},"source":"Crossref","is-referenced-by-count":20,"title":["Are we drawing the right conclusions from randomised placebo-controlled trials? A post-hoc analysis of data from a randomised controlled trial"],"prefix":"10.1186","volume":"9","author":[{"given":"M Diana","family":"van Die","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry M","family":"Bone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry G","family":"Burger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena J","family":"Teede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,6,23]]},"reference":[{"issue":"8","key":"357_CR1","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S0006-3223(00)00832-5","volume":"47","author":"I Kirsch","year":"2000","unstructured":"Kirsch I: Are drug and placebo effects in depression additive?. Biol Psychiatry. 2000, 47 (8): 733-735.","journal-title":"Biol Psychiatry"},{"key":"357_CR2","volume-title":"Prevention and Treatment","author":"I Kirsch","year":"1998","unstructured":"Kirsch I, Sapirstein G: Listening to prozac but hearing placebo: a meta-analysis of antidepressant medication. Prevention and Treatment. 1998, 1: [\n                    http:\/\/journals.apa.org\/prevention\/volume1\/pre0010002a.html\n                    \n                  ]"},{"issue":"2","key":"357_CR3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/00004850-199803000-00002","volume":"13","author":"SA Montgomery","year":"1998","unstructured":"Montgomery SA, Reimitz PE, Zivkov M: Mirtazapine versus amitriptyline in the long-term treatment of depression: a double-blind placebo-controlled study. Int Clin Psychopharmacol. 1998, 13 (2): 63-73.","journal-title":"Int Clin Psychopharmacol"},{"issue":"10","key":"357_CR4","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/070674379604101002","volume":"41","author":"R Joffe","year":"1996","unstructured":"Joffe R, Sokolov S, Streiner D: Antidepressant treatment of depression: a metaanalysis. Can J Psychiatry. 1996, 41 (10): 613-616.","journal-title":"Can J Psychiatry"},{"issue":"7","key":"357_CR5","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1002\/jclp.20129","volume":"61","author":"BE Wampold","year":"2005","unstructured":"Wampold BE, Minami T, Tierney SC, Baskin TW, Bhati KS: The placebo is powerful: estimating placebo effects in medicine and psychotherapy from randomized clinical trials. J Clin Psychol. 2005, 61 (7): 835-854.","journal-title":"J Clin Psychol"},{"issue":"1","key":"357_CR6","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1176\/appi.ajp.159.1.122","volume":"159","author":"AF Leuchter","year":"2002","unstructured":"Leuchter AF, Cook IA, Witte EA, Morgan M, Abrams M: Changes in brain function of depressed subjects during treatment with placebo. Am J Psychiatry. 2002, 159 (1): 122-129.","journal-title":"Am J Psychiatry"},{"issue":"5","key":"357_CR7","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1176\/appi.ajp.159.5.728","volume":"159","author":"HS Mayberg","year":"2002","unstructured":"Mayberg HS, Silva JA, Brannan SK, Tekell JL, Mahurin RK, McGinnis S, Jerabek PA: The functional neuroanatomy of the placebo effect. Am J Psychiatry. 2002, 159 (5): 728-737.","journal-title":"Am J Psychiatry"},{"issue":"1\u20132","key":"357_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00213-004-1919-2","volume":"177","author":"AF Leuchter","year":"2004","unstructured":"Leuchter AF, Morgan M, Cook IA, Dunkin J, Abrams M, Witte E: Pretreatment neurophysiological and clinical characteristics of placebo responders in treatment trials for major depression. Psychopharmacology (Berl). 2004, 177 (1\u20132): 15-22.","journal-title":"Psychopharmacology (Berl)"},{"issue":"7","key":"357_CR9","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nrn1705","volume":"6","author":"L Colloca","year":"2005","unstructured":"Colloca L, Benedetti F: Placebos and painkillers: is mind as real as matter?. Nat Rev Neurosci. 2005, 6 (7): 545-552.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"357_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jn.1998.80.1.1","volume":"80","author":"W Schultz","year":"1998","unstructured":"Schultz W: Predictive reward signal of dopamine neurons. J Neurophysiol. 1998, 80 (1): 1-27.","journal-title":"J Neurophysiol"},{"issue":"6","key":"357_CR11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nn1250","volume":"7","author":"F Benedetti","year":"2004","unstructured":"Benedetti F, Colloca L, Torre E, Lanotte M, Melcarne A, Pesare M, Bergamasco B, Lopiano L: Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus. Nat Neurosci. 2004, 7 (6): 587-588.","journal-title":"Nat Neurosci"},{"issue":"2\u20133","key":"357_CR12","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0149-7634(89)80024-7","volume":"13","author":"KB Franklin","year":"1989","unstructured":"Franklin KB: Analgesia and the neural substrate of reward. Neurosci Biobehav Rev. 1989, 13 (2\u20133): 149-154.","journal-title":"Neurosci Biobehav Rev"},{"issue":"6722","key":"357_CR13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/18019","volume":"398","author":"PA Garris","year":"1999","unstructured":"Garris PA, Kilpatrick M, Bunin MA, Michael D, Walker QD, Wightman RM: Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation. Nature. 1999, 398 (6722): 67-69.","journal-title":"Nature"},{"issue":"1","key":"357_CR14","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1533-2500.2007.00104.x","volume":"7","author":"EB Koshi","year":"2007","unstructured":"Koshi EB, Short CA: Placebo theory and its implications for research and clinical practice: a review of the recent literature. Pain Pract. 2007, 7 (1): 4-20.","journal-title":"Pain Pract"},{"issue":"26","key":"357_CR15","doi-asserted-by":"publisher","first-page":"11056","DOI":"10.1073\/pnas.0702413104","volume":"104","author":"TD Wager","year":"2007","unstructured":"Wager TD, Scott DJ, Zubieta JK: Placebo effects on human mu-opioid activity during pain. Proc Natl Acad Sci USA. 2007, 104 (26): 11056-11061.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"357_CR16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s11948-004-0072-y","volume":"10","author":"TR Weihrauch","year":"2004","unstructured":"Weihrauch TR: Placebo treatment is effective differently in different diseases\u2013but is it also harmless? A brief synopsis. Sci Eng Ethics. 2004, 10 (1): 151-155.","journal-title":"Sci Eng Ethics"},{"issue":"5","key":"357_CR17","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1097\/00001503-200310000-00012","volume":"16","author":"F Benedetti","year":"2003","unstructured":"Benedetti F, Rainero I, Pollo A: New insights into placebo analgesia. Curr Opin Anaesthesiol. 2003, 16 (5): 515-519.","journal-title":"Curr Opin Anaesthesiol"},{"issue":"4","key":"357_CR18","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1177\/0163278702238052","volume":"25","author":"R De La Fuente-Fernandez","year":"2002","unstructured":"De La Fuente-Fernandez R, Stoessl AJ: The biochemical bases for reward. Implications for the placebo effect. Eval Health Prof. 2002, 25 (4): 387-398.","journal-title":"Eval Health Prof"},{"issue":"2","key":"357_CR19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biopsych.2003.11.019","volume":"56","author":"R de la Fuente-Fernandez","year":"2004","unstructured":"de la Fuente-Fernandez R, Schulzer M, Stoessl AJ: Placebo mechanisms and reward circuitry: clues from Parkinson's disease. Biol Psychiatry. 2004, 56 (2): 67-71.","journal-title":"Biol Psychiatry"},{"key":"357_CR20","doi-asserted-by":"crossref","unstructured":"de la Fuente-Fernandez R, Lidstone S, Stoessl AJ: Placebo effect and dopamine release. J Neural Transm Suppl. 2006, 415-418. 70","DOI":"10.1007\/978-3-211-45295-0_62"},{"issue":"1","key":"357_CR21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1523\/JNEUROSCI.19-01-00484.1999","volume":"19","author":"M Amanzio","year":"1999","unstructured":"Amanzio M, Benedetti F: Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. J Neurosci. 1999, 19 (1): 484-494.","journal-title":"J Neurosci"},{"issue":"1","key":"357_CR22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/gme.0b013e31817fa9e0","volume":"16","author":"MD Van Die","year":"2009","unstructured":"Van Die MD, Burger HG, Bone KM, Cohen MM, Teede HJ: Hypericum perforatum with Vitex agnus-castus in menopausal symptoms: a randomized, controlled trial. Menopause. 2009, 16 (1): 156-163.","journal-title":"Menopause"},{"key":"357_CR23","volume-title":"Menopause","author":"MD Van Die","year":"2009","unstructured":"Van Die MD, Teede H, Bone K, Reece J, Burger H: Predictors of Placebo Response in a Randomised, Controlled Trial of Phytotherapy in Menopause. Menopause. 2009"},{"issue":"2","key":"357_CR24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jpsychires.2004.06.005","volume":"39","author":"A Khan","year":"2005","unstructured":"Khan A, Brodhead AE, Kolts RL, Brown WA: Severity of depressive symptoms and response to antidepressants and placebo in antidepressant trials. J Psychiatr Res. 2005, 39 (2): 145-150.","journal-title":"J Psychiatr Res"},{"issue":"6","key":"357_CR25","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1097\/01.jcp.0000145342.38170.7f","volume":"24","author":"JA Welge","year":"2004","unstructured":"Welge JA, Keck PE, Meinhold JM: Predictors of response to treatment of acute bipolar manic episodes with divalproex sodium or placebo in 2 randomized, controlled, parallel-group trials. J Clin Psychopharmacol. 2004, 24 (6): 607-612.","journal-title":"J Clin Psychopharmacol"},{"issue":"3","key":"357_CR26","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0165-1781(94)90078-7","volume":"52","author":"JH Heiligenstein","year":"1994","unstructured":"Heiligenstein JH, Faries DE, Rush AJ, Andersen JS, Pande AC, Roffwarg HP, Dunner D, Gillin JC, James SP, Lahmeyer H, Zajecka J, Tollefson GS, Gardner DM: Latency to rapid eye movement sleep as a predictor of treatment response to fluoxetine and placebo in nonpsychotic depressed outpatients. Psychiatry Res. 1994, 52 (3): 327-339.","journal-title":"Psychiatry Res"},{"issue":"2","key":"357_CR27","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/00005053-197302000-00004","volume":"156","author":"RW Downing","year":"1973","unstructured":"Downing RW, Rickels K: Predictors of response to amitriptyline and placebo in three outpatient treatment settings. J Nerv Ment Dis. 1973, 156 (2): 109-129.","journal-title":"J Nerv Ment Dis"},{"issue":"1","key":"357_CR28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1097\/00004714-200202000-00007","volume":"22","author":"A Khan","year":"2002","unstructured":"Khan A, Leventhal RM, Khan SR, Brown WA: Severity of depression and response to antidepressants and placebo: an analysis of the Food and Drug Administration database. J Clin Psychopharmacol. 2002, 22 (1): 40-45.","journal-title":"J Clin Psychopharmacol"},{"issue":"4","key":"357_CR29","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/j.1365-2982.2008.01241.x","volume":"21","author":"P Enck","year":"2009","unstructured":"Enck P, Vinson B, Malfertheiner P, Zipfel S, Klosterhalfen S: The placebo response in functional dyspepsia \u2013 reanalysis of trial data. Neurogastroenterol Motil. 2009, 21 (4): 370-377.","journal-title":"Neurogastroenterol Motil"}],"container-title":["BMC Medical Research Methodology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2288-9-41\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2288-9-41.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2288-9-41","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2288-9-41.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T22:47:02Z","timestamp":1548197222000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedresmethodol.biomedcentral.com\/articles\/10.1186\/1471-2288-9-41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,23]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["357"],"URL":"https:\/\/doi.org\/10.1186\/1471-2288-9-41","relation":{},"ISSN":["1471-2288"],"issn-type":[{"value":"1471-2288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,23]]},"article-number":"41"}}