{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:21:09Z","timestamp":1787019669760,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T00:00:00Z","timestamp":1269907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1186\/1471-230x-10-34","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T02:13:44Z","timestamp":1270001624000},"source":"Crossref","is-referenced-by-count":29,"title":["Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure"],"prefix":"10.1186","volume":"10","author":[{"given":"Philip N","family":"Newsome","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil C","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard J","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costas","family":"Dabos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Bellamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forbes","family":"Howie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E","family":"Clutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N","family":"Plevris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,30]]},"reference":[{"issue":"5","key":"425_CR1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1046\/j.1365-2036.1998.00320.x","volume":"12","author":"JN Plevris","year":"1998","unstructured":"Plevris JN, Schina M, Hayes PC: Review article: the management of acute liver failure. Aliment Pharmacol Ther. 1998, 12 (5): 405-418. 10.1046\/j.1365-2036.1998.00320.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"425_CR2","first-page":"282","volume":"3","author":"C Trey","year":"1970","unstructured":"Trey C, Davidson CS: The management of fulminant hepatic failure. Prog Liver Dis. 1970, 3: 282-298.","journal-title":"Prog Liver Dis"},{"issue":"1","key":"425_CR3","first-page":"21","volume":"6","author":"PN Newsome","year":"2000","unstructured":"Newsome PN, Plevris JN, Nelson LJ, Hayes PC: Animal models of fulminant hepatic failure: a critical evaluation. Liver Transpl. 2000, 6 (1): 21-31.","journal-title":"Liver Transpl"},{"issue":"9293","key":"425_CR4","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1016\/S0140-6736(01)06663-6","volume":"358","author":"PN Newsome","year":"2001","unstructured":"Newsome PN, Bathgate AJ, Henderson NC, MacGilchrist AJ, Plevris JN, Masterton G, et al: Referral patterns and social deprivation in paracetamol-induced liver injury in Scotland. Lancet. 2001, 358 (9293): 1612-1613. 10.1016\/S0140-6736(01)06663-6.","journal-title":"Lancet"},{"issue":"5","key":"425_CR5","first-page":"408","volume":"56","author":"BG Gazzard","year":"1975","unstructured":"Gazzard BG, Hughes RD, Mellon PJ, Portmann B, Williams R: A dog model of fulminant hepatic failure produced by paracetamol administration. Br J Exp Pathol. 1975, 56 (5): 408-411.","journal-title":"Br J Exp Pathol"},{"issue":"7698","key":"425_CR6","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0140-6736(71)91125-1","volume":"1","author":"LF Prescott","year":"1971","unstructured":"Prescott LF, Roscoe P, Wright N, Brown SS: Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet. 1971, 1 (7698): 519-522. 10.1016\/S0140-6736(71)91125-1.","journal-title":"Lancet"},{"issue":"2 Pt 1","key":"425_CR7","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0016-5085(89)91573-4","volume":"96","author":"A Francavilla","year":"1989","unstructured":"Francavilla A, Makowka L, Polimeno L, Barone M, Demetris J, Prelich J, et al: A dog model for acetaminophen-induced fulminant hepatic failure. Gastroenterology. 1989, 96 (2 Pt 1): 470-478.","journal-title":"Gastroenterology"},{"issue":"2","key":"425_CR8","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/hep.1840150225","volume":"15","author":"JH Kelly","year":"1992","unstructured":"Kelly JH, Koussayer T, He DE, Chong MG, Shang TA, Whisennand HH, et al: An improved model of acetaminophen-induced fulminant hepatic failure in dogs. Hepatology. 1992, 15 (2): 329-335. 10.1002\/hep.1840150225.","journal-title":"Hepatology"},{"issue":"1","key":"425_CR9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3565(25)29664-1","volume":"187","author":"DJ Jollow","year":"1973","unstructured":"Jollow DJ, Mitchell JR, Potter WZ, Davis DC, Gillette JR, Brodie BB: Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther. 1973, 187 (1): 195-202.","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"425_CR10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-3565(25)29666-5","volume":"187","author":"JR Mitchell","year":"1973","unstructured":"Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB: Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther. 1973, 187 (1): 211-217.","journal-title":"J Pharmacol Exp Ther"},{"issue":"16","key":"425_CR11","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1016\/S0021-9258(18)35980-5","volume":"254","author":"OW Griffith","year":"1979","unstructured":"Griffith OW, Meister A: Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979, 254 (16): 7558-7560.","journal-title":"J Biol Chem"},{"issue":"1","key":"425_CR12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0016-5085(76)80107-2","volume":"71","author":"DJ Miller","year":"1976","unstructured":"Miller DJ, Hickman R, Fratter R, Terblanche J, Saunders SJ: An animal model of fulminant hepatic failure: a feasibility study. Gastroenterology. 1976, 71 (1): 109-113.","journal-title":"Gastroenterology"},{"issue":"6","key":"425_CR13","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/bem.10122","volume":"24","author":"G Schmid","year":"2003","unstructured":"Schmid G, Neubauer G, Illievich UM, Alesch F: Dielectric properties of porcine brain tissue in the transition from life to death at frequencies from 800 to 1900 MHz. Bioelectromagnetics. 2003, 24 (6): 413-422. 10.1002\/bem.10122.","journal-title":"Bioelectromagnetics"},{"issue":"2","key":"425_CR14","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/0003-2697(76)90114-7","volume":"75","author":"T Matsubara","year":"1976","unstructured":"Matsubara T, Koike M, Touchi A, Tochino Y, Sugeno K: Quantitative determination of cytochrome P-450 in rat liver homogenate. Anal Biochem. 1976, 75 (2): 596-603. 10.1016\/0003-2697(76)90114-7.","journal-title":"Anal Biochem"},{"key":"425_CR15","volume-title":"Practical Haematology","author":"JV Dacie","year":"1994","unstructured":"Dacie JV, Lewis SM: Measurement of methaemoglobin in blood. Practical Haematology. Edited by: Dacie JV, Lewis SM. 1994, London: Churchill and Livingstone"},{"issue":"10","key":"425_CR16","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1080\/00365520410003227","volume":"39","author":"LE Schmidt","year":"2004","unstructured":"Schmidt LE, Tofteng F, Strauss GI, Larsen FS: Effect of treatment with the Molecular Adsorbents Recirculating System on arterial amino acid levels and cerebral amino acid metabolism in patients with hepatic encephalopathy. Scand J Gastroenterol. 2004, 39 (10): 974-980. 10.1080\/00365520410003227.","journal-title":"Scand J Gastroenterol"},{"issue":"11","key":"425_CR17","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1080\/004982599238047","volume":"29","author":"JK Nicholson","year":"1999","unstructured":"Nicholson JK, Lindon JC, Holmes E: 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999, 29 (11): 1181-1189. 10.1080\/004982599238047.","journal-title":"Xenobiotica"},{"issue":"6","key":"425_CR18","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1007\/BF01311235","volume":"36","author":"J Terblanche","year":"1991","unstructured":"Terblanche J, Hickman R: Animal models of fulminant hepatic failure. Dig Dis Sci. 1991, 36 (6): 770-774. 10.1007\/BF01311235.","journal-title":"Dig Dis Sci"},{"issue":"8","key":"425_CR19","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1097\/00042737-200012080-00012","volume":"12","author":"LJ Nelson","year":"2000","unstructured":"Nelson LJ, Newsome PN, Howie AF, Hadoke PW, Dabos KJ, Walker SW, et al: An improved ex vivo method of primary porcine hepatocyte isolation for use in bioartificial liver systems. Eur J Gastroenterol Hepatol. 2000, 12 (8): 923-930. 10.1097\/00042737-200012080-00012.","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"4","key":"425_CR20","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1136\/thx.50.4.399","volume":"50","author":"SV Baudouin","year":"1995","unstructured":"Baudouin SV, Howdle P, O'Grady JG, Webster NR: Acute lung injury in fulminant hepatic failure following paracetamol poisoning. Thorax. 1995, 50 (4): 399-402. 10.1136\/thx.50.4.399.","journal-title":"Thorax"},{"issue":"2","key":"425_CR21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/00000658-199508000-00002","volume":"222","author":"H Bismuth","year":"1995","unstructured":"Bismuth H, Samuel D, Castaing D, Adam R, Saliba F, Johann M, et al: Orthotopic liver transplantation in fulminant and subfulminant hepatitis. The Paul Brousse experience. Ann Surg. 1995, 222 (2): 109-119. 10.1097\/00000658-199508000-00002.","journal-title":"Ann Surg"},{"issue":"1 Suppl 1","key":"425_CR22","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/S0272-6386(96)90561-2","volume":"28","author":"RC Blantz","year":"1996","unstructured":"Blantz RC: Acetaminophen: acute and chronic effects on renal function. Am J Kidney Dis. 1996, 28 (1 Suppl 1): S3-S6. 10.1016\/S0272-6386(96)90561-2.","journal-title":"Am J Kidney Dis"},{"key":"425_CR23","first-page":"27","volume-title":"Red blood cells of domestic animals","author":"N Agar","year":"1983","unstructured":"Agar N, Board P: Red cell metabolism. Red blood cells of domestic animals. Edited by: Agar N, Board P. 1983, Amsterdam: Elsevier, 27-52."},{"issue":"6","key":"425_CR24","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/BF01852004","volume":"188","author":"D Henne-Bruns","year":"1988","unstructured":"Henne-Bruns D, Artwohl J, Broelsch C, Kremer B: Acetaminophen-induced acute hepatic failure in pigs: controversical results to other animal models. Res Exp Med (Berl). 1988, 188 (6): 463-472. 10.1007\/BF01852004.","journal-title":"Res Exp Med (Berl)"},{"issue":"3-4","key":"425_CR25","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0300-483X(84)90114-8","volume":"31","author":"SL Nash","year":"1984","unstructured":"Nash SL, Savides MC, Oehme FW, Johnson DE: The effect of acetaminophen on methemoglobin and blood glutathione parameters in the cat. Toxicology. 1984, 31 (3-4): 329-334. 10.1016\/0300-483X(84)90114-8.","journal-title":"Toxicology"},{"issue":"1","key":"425_CR26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/0041-008X(84)90266-7","volume":"74","author":"MC Savides","year":"1984","unstructured":"Savides MC, Oehme FW, Nash SL, Leipold HW: The toxicity and biotransformation of single doses of acetaminophen in dogs and cats. Toxicol Appl Pharmacol. 1984, 74 (1): 26-34. 10.1016\/0041-008X(84)90266-7.","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-230X-10-34\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-10-34.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-10-34","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-10-34.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T14:55:29Z","timestamp":1739976929000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/1471-230X-10-34"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,30]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["425"],"URL":"https:\/\/doi.org\/10.1186\/1471-230x-10-34","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,30]]},"article-number":"34"}}