{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:50:24Z","timestamp":1771026624698,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T00:00:00Z","timestamp":1310688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Acute liver injury (ALI) induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug.<\/jats:p>\n            <jats:p>The aim is to describe the characteristics of patients admitted to hospital with jaundice who had previous exposure to therapeutic doses of paracetamol. An assessment of the causality role of paracetamol was performed in each case.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Based on the evaluation of prospectively gathered cases of ALI with detailed clinical information, thirty-two cases of ALI in non-alcoholic patients exposed to therapeutic doses of paracetamol were identified. Two authors assessed all drug exposures by using the CIOMS\/RUCAM scale. Each case was classified into one of five categories based on the causality score for paracetamol.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In four cases the role of paracetamol was judged to be unrelated, in two unlikely, and these were excluded from evaluation. In seven of the remaining 26 cases, the RUCAM score associated with paracetamol was higher than that associated with other concomitant medications. The estimated incidence of ALI related to the use of paracetamol in therapeutic dosages was 0.4 per million inhabitants older than 15 years of age and per year (99%CI, 0.2-0.8) and of 10 per million paracetamol users-year (95% CI 4.3-19.4).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our results indicate that paracetamol in therapeutic dosages may be considered in the causality assessment in non-alcoholic patients with liver injury, even if the estimated incidence of ALI related to paracetamol appears to be low.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-230x-11-80","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T18:16:58Z","timestamp":1310753818000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series"],"prefix":"10.1186","volume":"11","author":[{"given":"M\u00f2nica","family":"Sabat\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eul\u00e0lia","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Buti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Xiol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Mas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Guarner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Forn\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricard","family":"Sol\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Castellote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Rigau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan-Ramon","family":"Laporte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,7,15]]},"reference":[{"key":"615_CR1","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1002\/hep.20948","volume":"42","author":"AM Larson","year":"2005","unstructured":"Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, Reisch JS, Schiodt FV, Ostapowicz G, Shakil AO, Lee WM, Acute Liver Failure Study Group: Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005, 42: 1364-72. 10.1002\/hep.20948.","journal-title":"Hepatology"},{"key":"615_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1572-0241.2007.01388.x","volume":"102","author":"WA Bower","year":"2007","unstructured":"Bower WA, Johns M, Margolis HS, Williams IT, Bell BP: Population-based surveillance for acute liver failure. Am J Gastroenterol. 2007, 102: 1-5. 10.1111\/j.1572-0241.2007.01057.x.","journal-title":"Am J Gastroenterol"},{"key":"615_CR3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S1481803500015153","volume":"9","author":"RP Myers","year":"2007","unstructured":"Myers RP, Li B, Shaheen AA: Emergency department visits for acetaminophen overdose: a Canadian population-based epidemiologic study (1997-2002). CJEM. 2007, 9: 267-74.","journal-title":"CJEM"},{"key":"615_CR4","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1002\/hep.22177","volume":"47","author":"WM Lee","year":"2008","unstructured":"Lee WM, Squires RH, Nyberg SL, Doo E, Hoofnagle JH: Acute liver failure: summary of a workshop. Hepatology. 2008, 47: 1401-15.","journal-title":"Hepatology"},{"key":"615_CR5","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.clinthera.2006.05.002","volume":"28","author":"O Moling","year":"2006","unstructured":"Moling O, Cairon E, Rimenti G, Rizza F, Prister\u00e1 R, Mian P: Severe hepatotoxicity after therapeutic doses of acetaminophen. Clin Ther. 2006, 28: 755-60. 10.1016\/j.clinthera.2006.05.002.","journal-title":"Clin Ther"},{"key":"615_CR6","doi-asserted-by":"publisher","first-page":"947","DOI":"10.7326\/0003-4819-137-12-200212170-00007","volume":"137","author":"G Ostapowicz","year":"2002","unstructured":"Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Davern TJ, Han SHB: Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002, 137: 947-54.","journal-title":"Ann Intern Med"},{"key":"615_CR7","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1002\/lt.21119","volume":"13","author":"A Escorsell","year":"2007","unstructured":"Escorsell A, Mas A, de la Mata M, Spanish Group for the Study of Acute Liver Failure: Acute liver failure in Spain: analysis of 267 cases. Liver Transpl. 2007, 13: 1389-95. 10.1002\/lt.21119.","journal-title":"Liver Transpl"},{"key":"615_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/00045391-200007020-00007","volume":"7","author":"LF Prescott","year":"2000","unstructured":"Prescott LF: Therapeutic misadventure with paracetamol: fact or fiction. Am J Ther. 2000, 7: 99-114. 10.1097\/00045391-200007020-00007.","journal-title":"Am J Ther"},{"key":"615_CR9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2165\/00002018-200528030-00004","volume":"28","author":"GG Graham","year":"2005","unstructured":"Graham GG, Scott KF, Day RO: Tolerability of paracetamol. Drug Safety. 2005, 28: 227-40. 10.2165\/00002018-200528030-00004.","journal-title":"Drug Safety"},{"key":"615_CR10","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1592\/phco.27.9.1219","volume":"27","author":"RC Dart","year":"2007","unstructured":"Dart RC, Bailey E: Does therapeutic use of acetaminophen cause acute liver failure?. Pharmacotherapy. 2007, 27: 1219-30. 10.1592\/phco.27.9.1219.","journal-title":"Pharmacotherapy"},{"key":"615_CR11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1001\/jama.296.1.87","volume":"296","author":"PB Watkins","year":"2006","unstructured":"Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC: Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily. JAMA. 2006, 296: 87-93. 10.1001\/jama.296.1.87.","journal-title":"JAMA"},{"key":"615_CR12","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1111\/j.1365-2036.2007.03338.x","volume":"25","author":"M Sabat\u00e9","year":"2007","unstructured":"Sabat\u00e9 M, Ib\u00e1\u00f1ez L, P\u00e9rez E, Vidal X, Buti M, Xiol X, Mas A, Guarner C, Forne M, Sola R, Castellote J, Rigau J, Laporte JR: Risk of acute liver injury associated with the use of drugs: a multicentre population survey. Aliment Pharmacol Ther. 2007, 25: 1401-09. 10.1111\/j.1365-2036.2007.03338.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"615_CR13","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/0168-8278(90)90124-A","volume":"11","author":"C Benichou","year":"1990","unstructured":"Benichou C: Criteria of drug-induced liver disease. Report of International Consensus Meeting. J Hepatol. 1990, 11: 272-76.","journal-title":"J Hepatol"},{"key":"615_CR14","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/S0168-8278(02)00231-3","volume":"37","author":"L Ib\u00e1\u00f1ez","year":"2002","unstructured":"Ib\u00e1\u00f1ez L, P\u00e9rez E, Vidal X, Laporte JR, Grup d'Estudi Multic\u00e8nteric d'Hepatotoxicitat Aguda de Barcelona (GEMHAB): Prospective surveillance of acute serious liver disease unrelated to infectious, obstructive, or metabolic diseases: epidemiological and clinical features, and exposure to drugs. J Hepatol. 2002, 37: 592-600. 10.1016\/S0168-8278(02)00231-3.","journal-title":"J Hepatol"},{"key":"615_CR15","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/0895-4356(93)90101-6","volume":"46","author":"G Danan","year":"1993","unstructured":"Danan G, Benichou C: Causality assessment of adverse reactions to drugs - I. A novel method based on the conclusions of internal consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol. 1993, 46: 1323-30. 10.1016\/0895-4356(93)90101-6.","journal-title":"J Clin Epidemiol"},{"key":"615_CR16","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1053\/jhep.2001.20645","volume":"33","author":"MI Lucena","year":"2001","unstructured":"Lucena MI, Camargo R, Andrade RJ, Perez-Sanchez CJ, Sanchez de la Cuesta: Comparison of two clinical scales for causality assessment in hepatotoxicity. Hepatology. 2001, 33: 123-30. 10.1053\/jhep.2001.20645.","journal-title":"Hepatology"},{"key":"615_CR17","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/S0168-8278(00)80136-1","volume":"33","author":"WM Lee","year":"2000","unstructured":"Lee WM: Assessing causality in drug-induced liver injury. J Hepatol. 2000, 33: 1003-05. 10.1016\/S0168-8278(00)80136-1.","journal-title":"J Hepatol"},{"key":"615_CR18","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1111\/j.1365-2036.2008.03655.x","volume":"27","author":"M Garc\u00eda-Cort\u00e9s","year":"2008","unstructured":"Garc\u00eda-Cort\u00e9s M, Lucena MI, Pachkoria K, Borraz Y, Hidalgo R, Andrade RJ, Spanish Group for the Study of Drug-induced Liver Disease (Grupo de Estudio para las Hepatopat\u00edas Asociadas a Medicamentos): Evaluation of Naranjo adverse drug reactions probability scale in causality assessment of drug-induced liver injury. Aliment Pharmacol Ther. 2008, 27: 780-89. 10.1111\/j.1365-2036.2008.03655.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"615_CR19","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/0895-4356(93)90102-7","volume":"46","author":"C Benichou","year":"1993","unstructured":"Benichou C, Danan G, Flahault A: Causality assessment of adverse reactions to drugs - II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol. 1993, 46: 1331-36. 10.1016\/0895-4356(93)90102-7.","journal-title":"J Clin Epidemiol"},{"key":"615_CR20","volume-title":"Versi\u00f3n 4. Madrid","author":"BOT y Atenci\u00f3n Farmac\u00e9utica","year":"2009","unstructured":"BOT y Atenci\u00f3n Farmac\u00e9utica: (CD-ROM) Consejo General de Colegios Oficiales de Farmac\u00e9uticos. Versi\u00f3n 4. Madrid. 2009"},{"key":"615_CR21","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S1089-3261(03)00025-4","volume":"7","author":"MQ Bromer","year":"2003","unstructured":"Bromer MQ, Black M: Acetaminophen hepatotoxicity. Clin Liver Dis. 2003, 7: 351-67. 10.1016\/S1089-3261(03)00025-4.","journal-title":"Clin Liver Dis"},{"key":"615_CR22","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/01.mog.0000218958.40441.fd","volume":"22","author":"JH Lewis","year":"2006","unstructured":"Lewis JH, Ahmed M, Shobassy A, Palese C: Drug-induced liver disease. Curr Opin Gastroenterol. 2006, 22: 223-33. 10.1097\/01.mog.0000218958.40441.fd.","journal-title":"Curr Opin Gastroenterol"},{"key":"615_CR23","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s11894-999-0086-3","volume":"1","author":"CJ McClain","year":"1999","unstructured":"McClain CJ, Price S, Barve S, Devalarja R, Shedlofsky S: Acetaminophen hepatotoxicity: an update. Curr Gastroenterol Rep. 1999, 1: 42-49. 10.1007\/s11894-999-0086-3.","journal-title":"Curr Gastroenterol Rep"},{"key":"615_CR24","first-page":"425","volume-title":"Drug-induced liver disease","author":"JS Leeder","year":"2003","unstructured":"Leeder JS, Pirmohamed M: Anticonvulsant agents. Drug-induced liver disease. Edited by: Kaplowitz N, DeLeve LD. 2003, New York: Marcel Dekker, 425-46."},{"key":"615_CR25","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/hep.20300","volume":"40","author":"BH Rumack","year":"2004","unstructured":"Rumack BH: Acetaminophen misconceptions. Hepatology. 2004, 40: 10-15.","journal-title":"Hepatology"},{"key":"615_CR26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/hep.20312","volume":"40","author":"N Kaplowitz","year":"2004","unstructured":"Kaplowitz N: Acetaminophen hepatotoxicity: what do we know, what don't we know, and what do we do next?. Hepatology. 2004, 40: 23-26.","journal-title":"Hepatology"},{"key":"615_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1081\/CLT-120002882","volume":"40","author":"BH Rumack","year":"2002","unstructured":"Rumack BH: Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002, 40: 3-20. 10.1081\/CLT-120002882.","journal-title":"J Toxicol Clin Toxicol"},{"key":"615_CR28","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1001\/archinte.162.10.1193","volume":"162","author":"JL Holtzman","year":"2002","unstructured":"Holtzman JL: The effect of alcohol on acetaminophen hepatotoxicity. Arch Intern Med. 2002, 162: 1193-10.1001\/archinte.162.10.1193.","journal-title":"Arch Intern Med"},{"key":"615_CR29","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1001\/archinte.161.18.2247","volume":"161","author":"EK Kuffner","year":"2001","unstructured":"Kuffner EK, Dart RC, Bogdan GM, Hill RE, Casper E, Darton L: Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients. Arch Intern Med. 2001, 161: 2247-52. 10.1001\/archinte.161.18.2247.","journal-title":"Arch Intern Med"},{"key":"615_CR30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1365-2036.2007.03368.x","volume":"26","author":"K Heard","year":"2007","unstructured":"Heard K, Green JL, Bailey JE, Bogdan GM, Dart RC: A randomized trial to determine the change in alanine aminotransferase during 10 days of acetaminophen (acetaminophen) administration in subjects who consume moderate amounts of alcohol. Aliment Pharmacol Ther. 2007, 26: 283-90. 10.1111\/j.1365-2036.2007.03368.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"615_CR31","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/S0168-8278(98)80361-9","volume":"28","author":"RJ Andrade","year":"1998","unstructured":"Andrade RJ, Lucena MI, Garc\u00eda-Esca\u00f1o MD, Camargo R: Severe idiosyncratic acute hepatic injury caused by paracetamol. J Hepatol. 1998, 28: 1078-80. 10.1016\/S0168-8278(98)80361-9.","journal-title":"J Hepatol"},{"key":"615_CR32","first-page":"317","volume":"109","author":"RJ Andrade","year":"1997","unstructured":"Andrade RJ, Lucena MI, Fern\u00e1ndez-S\u00e1nchez MC, Pel\u00e1ez G: Hepatotoxicidad por paracetamol a dosis terap\u00e9uticas. Med Clin. 1997, 109: 317-18.","journal-title":"Med Clin"},{"key":"615_CR33","first-page":"314","volume":"21","author":"RJ Andrade","year":"1998","unstructured":"Andrade RJ, Lucena MI, Melgarejo F, Garc\u00eda-Esca\u00f1o MD: Hepatotoxicity caused by isoniazid or paracetamol. Gastroenterol Hepatol. 1998, 21: 314-15.","journal-title":"Gastroenterol Hepatol"},{"key":"615_CR34","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1177\/106002800203600901","volume":"36","author":"S Bolesta","year":"2002","unstructured":"Bolesta S, Haber SL: Hepatotoxicity associated with chronic acetaminophen administration patients without risk factors. Ann Pharmacother. 2002, 36: 1482-83.","journal-title":"Ann Pharmacother"},{"key":"615_CR35","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.clinthera.2006.05.002","volume":"28","author":"O Moling","year":"2006","unstructured":"Moling O, Cairon E, Rimenti G, Rizza F, Prister\u00e1 R, Mian P: Severe hepatotoxicity after therapeutic doses of acetaminophen. Clin Ther. 2006, 28: 755-60. 10.1016\/j.clinthera.2006.05.002.","journal-title":"Clin Ther"},{"key":"615_CR36","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1046\/j.1365-2796.2003.01097.x","volume":"253","author":"J Kurtovic","year":"2003","unstructured":"Kurtovic J, Riordan SM: Acetaminophen-induced hepatotoxicity at recommended dosage. J Intern Med. 2003, 253: 240-43. 10.1046\/j.1365-2796.2003.01097.x.","journal-title":"J Intern Med"},{"key":"615_CR37","first-page":"47","volume":"39","author":"C Gu\u00e9rin","year":"1984","unstructured":"Gu\u00e9rin C, Casez JP, Vital-Durand D, Levrat R: Allergy to paracetamol. A case of hepatic and cutaneous involvement. Therapie. 1984, 39: 47-49.","journal-title":"Therapie"},{"key":"615_CR38","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1046\/j.1365-2125.2002.01603.x","volume":"53","author":"TH Bacon","year":"2002","unstructured":"Bacon TH, Hole JG, North M, Burnett I: Analgesic efficacy of sustained release paracetamol in patients with osteoarthritis of the knee. Br J Clin Pharmacol. 2002, 53: 629-36. 10.1046\/j.1365-2125.2002.01603.x.","journal-title":"Br J Clin Pharmacol"},{"key":"615_CR39","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.1086\/381446","volume":"38","author":"N Kaplowitz","year":"2004","unstructured":"Kaplowitz N: Drug-induced liver injury. Clin Infect Dis. 2004, 38: S44-S48. 10.1086\/381446.","journal-title":"Clin Infect Dis"},{"key":"615_CR40","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1111\/j.1398-9995.2005.00855.x","volume":"60","author":"K Boussetta","year":"2005","unstructured":"Boussetta K, Ponvert C, Karila C, Bourgeois ML, Blic J, Scheinmann P: Hypersensitivity reactions to paracetamol in children: a study of 25 cases. Allergy. 2005, 60: 1174-77. 10.1111\/j.1398-9995.2005.00855.x.","journal-title":"Allergy"},{"key":"615_CR41","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/S1081-1206(10)62580-X","volume":"85","author":"BJ de Paramo","year":"2000","unstructured":"de Paramo BJ, Gancedo SQ, Cuevas M, Camo IP, Martin JA, Cosmes EL: Paracetamol (acetaminophen) hypersensitivity. Ann Allergy Asthma Immunol. 2000, 85: 508-11. 10.1016\/S1081-1206(10)62580-X.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"615_CR42","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1046\/j.1365-2222.2002.01476.x","volume":"32","author":"V Kvedariene","year":"2002","unstructured":"Kvedariene V, Bencherioua AM, Messaad D, Godard P, Bousquet J, Demoly P: The accuracy of the diagnosis of suspected paracetamol (acetaminophen) hypersensitivity: results of a single-blinded trial. Clin Exp Allergy. 2002, 32: 1366-69. 10.1046\/j.1365-2222.2002.01476.x.","journal-title":"Clin Exp Allergy"},{"key":"615_CR43","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5858\/133.2.309","volume":"133","author":"B Kenney","year":"2009","unstructured":"Kenney B, Stack G: Drug-induced Thrombocytopenia. Arch Pathol Lab Med. 2009, 133: 309-314.","journal-title":"Arch Pathol Lab Med"},{"key":"615_CR44","volume-title":"AGEMED","author":"LC Abecia","year":"2009","unstructured":"Abecia LC, Garc\u00eda del Pozo J, de Abajo FJ: Utilizaci\u00f3n de analg\u00e9sicos no opioides en Espa\u00f1a 1992-2006. AGEMED. 2009, [http:\/\/www.aemps.gob.es\/medicamentosUsoHumano\/observatorio\/docs\/analgesicos_no_opio.pdf]"},{"key":"615_CR45","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/j.1472-8206.2008.00566.x","volume":"22","author":"MI Lucena","year":"2008","unstructured":"Lucena MI, Garc\u00eda-Cort\u00e9s M, Cueto R, Lopez-Duran J, Andrade RJ: Assessment of drug-induced liver injury in clinical practice. Fundam Clin Pharmacol. 2008, 22: 141-58. 10.1111\/j.1472-8206.2008.00566.x.","journal-title":"Fundam Clin Pharmacol"},{"key":"615_CR46","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1053\/j.gastro.2008.09.011","volume":"135","author":"N Chalasani","year":"2008","unstructured":"Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J, Drug Induced Liver Injury Network (DILIN): Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology. 2008, 135: 1924-34. 10.1053\/j.gastro.2008.09.011.","journal-title":"Gastroenterology"},{"key":"615_CR47","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.cld.2007.06.003","volume":"11","author":"MA Shapiro","year":"2007","unstructured":"Shapiro MA, Lewis JH: Causality assessment of drug-induced hepatotoxicity: promises and pitfalls. Clin Liver Dis. 2007, 11: 477-505. 10.1016\/j.cld.2007.06.003.","journal-title":"Clin Liver Dis"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-11-80.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-230X-11-80\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-11-80","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-11-80.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T15:29:45Z","timestamp":1630510185000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/1471-230X-11-80"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,15]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["615"],"URL":"https:\/\/doi.org\/10.1186\/1471-230x-11-80","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,15]]},"assertion":[{"value":"1 December 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"80"}}