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Their mean age was 41\u2009\u00b1\u200913\u00a0years (range 18\u201377) and male: female ratio of 2:1.<jats:italic>H. pylori<\/jats:italic>were cultured and antibiotic sensitivity was determined by Epsilometer test (E-test) for clarithromycin (CLR) and amoxicillin (AMX). Primers of<jats:italic>urease C<\/jats:italic>gene of<jats:italic>H. pylori<\/jats:italic>and Sau-3 and Hha I restriction enzymes were used for polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP).<jats:sup>14<\/jats:sup>C urea breath test (<jats:sup>14<\/jats:sup>C-UBT) was performed 4\u00a0weeks after the eradication therapy. The successfully treated patients were observed for 12\u00a0months with<jats:sup>14<\/jats:sup>C-UBT to assess<jats:italic>H. pylori<\/jats:italic>status. If<jats:sup>14<\/jats:sup>C-UBT was negative, it was repeated after every 12\u00a0weeks. If<jats:sup>14<\/jats:sup>C-UBT was positive, endoscopy was repeated with biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The eradication therapy was successful in 102(85%) patients. Out of forty-seven<jats:italic>H. pylori<\/jats:italic>isolates cultured, clarithromycin sensitivity was present in 30(64%) and amoxicillin in 45(98%), respectively. Follow-up<jats:sup>14<\/jats:sup>C-urea breath tests of all 102 patients who eradicated<jats:italic>H. pylori<\/jats:italic>remained negative up to 9\u00a0months. However, in 6 patients, the<jats:sup>14<\/jats:sup>C-UBT confirmed recurrence at 12\u00a0months. The recurrence rate was 6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A low rate of recurrence of<jats:italic>H. pylori<\/jats:italic>infection was found in patients with dyspeptic symptoms.<jats:italic>H. pylori<\/jats:italic>isolates demonstrated a high invitro clarithromycin resistance.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-230x-13-33","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T19:59:45Z","timestamp":1361476785000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low rate of recurrence of Helicobacter Pylori infection in spite of high clarithromycin resistance in Pakistan"],"prefix":"10.1186","volume":"13","author":[{"given":"Javed","family":"Yakoob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahab","family":"Abid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasim","family":"Jafri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaigham","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Mumtaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashida","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"912_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/jama.1994.03520010077036","volume":"272","author":"Anon","year":"1994","unstructured":"Anon: NIH consensus conference. 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