{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:31:44Z","timestamp":1779895904199,"version":"3.53.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,4,21]],"date-time":"2013-04-21T00:00:00Z","timestamp":1366502400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1471-230x-13-68","type":"journal-article","created":{"date-parts":[[2013,4,21]],"date-time":"2013-04-21T02:14:31Z","timestamp":1366510471000},"source":"Crossref","is-referenced-by-count":60,"title":["Management of irritable bowel syndrome in primary care: the results of an exploratory randomised controlled trial of mebeverine, methylcellulose, placebo and a self-management website"],"prefix":"10.1186","volume":"13","author":[{"given":"Hazel","family":"Everitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona","family":"Moss-Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Sibelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Yardley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,21]]},"reference":[{"key":"937_CR1","first-page":"1","volume":"56","author":"British Society of Gastroenterology","year":"2007","unstructured":"British Society of Gastroenterology: Care of patients with gastrointestinal disorders in the United Kingdom: a strategy for the future. Gut. 2007, 56: 1-56.","journal-title":"Gut"},{"issue":"2","key":"937_CR2","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1136\/gut.48.2.272","volume":"48","author":"R Akehurst","year":"2001","unstructured":"Akehurst R, Kaltenthaler E: Treatment of irritable bowel syndrome: a review of randomised controlled trials. Gut. 2001, 48 (2): 272-282. 10.1136\/gut.48.2.272.","journal-title":"Gut"},{"issue":"12","key":"937_CR3","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1136\/gut.2007.119446","volume":"56","author":"R Spiller","year":"2007","unstructured":"Spiller R, Aziz Q, Creed F, Emmanuel A, Houghton L, Hungin P: Guidelines for the management of Irritable Bowel Syndrome. Gut. 2007, 56 (12): 1770-1798. 10.1136\/gut.2007.119446. 8-5-2007.","journal-title":"Gut"},{"issue":"11","key":"937_CR4","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1136\/gut.28.11.1510","volume":"28","author":"A Prior","year":"1987","unstructured":"Prior A, Whorwell PJ: Double blind study of ispaghula in irritable bowel syndrome. Gut. 1987, 28 (11): 1510-1513. 10.1136\/gut.28.11.1510.","journal-title":"Gut"},{"key":"937_CR5","volume-title":"Irritable bowel syndrome in adults","author":"NICE","year":"2008","unstructured":"NICE: Irritable bowel syndrome in adults. 2008, NICE, \n                    http:\/\/guidance.nice.org.uk\/CG61\n                    \n                  ,"},{"key":"937_CR6","doi-asserted-by":"crossref","unstructured":"Ruepert L, Quartero AO, de Wit NJ, van der Heijden GJ, Rubin G, Muris JWM: Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome. Cochrane Database of Systematic Reviews. 2011, \u2009: \u2009-Issue 8. Art. No.: CD003460. DOI: 10.1002\/14651858.CD003460.pub3","DOI":"10.1002\/14651858.CD003460.pub3"},{"key":"937_CR7","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1136\/bmj.39199.679236.AE","volume":"334","author":"B Hayee","year":"2007","unstructured":"Hayee B, Forgacs I: Clinical review: psychological approach to managing irritable bowel syndrome. BMJ. 2007, 334: 1105-1109. 10.1136\/bmj.39199.679236.AE.","journal-title":"BMJ"},{"issue":"7514","key":"937_CR8","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1136\/bmj.38545.505764.06","volume":"331","author":"T Kennedy","year":"2005","unstructured":"Kennedy T, Jones R, Darnley S, Seed P, Wessely S, Chalder T: Cognitive behaviour therapy in addition to antispasmodic treatment for irritable bowel syndrome in primary care: randomised controlled trial. BMJ. 2005, 331 (7514): 435-437. 10.1136\/bmj.38545.505764.06.","journal-title":"BMJ"},{"key":"937_CR9","volume-title":"Cochrane Database of Systematic Reviews","author":"IL Zijdenbos","year":"2009","unstructured":"Zijdenbos IL, de Wit NJ, van der Heijden GJ, Rubin G, Quartero AO: Psychological treatments for the management of irritable bowel syndrome. Cochrane Database of Systematic Reviews. 2009, Issue 1. Art. No.: CD006442. DOI: 10.1002\/14651858.CD006442.pub2"},{"key":"937_CR10","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.cgh.2008.03.004","volume":"6","author":"JM Lackner","year":"2008","unstructured":"Lackner JM, Jaccard J, Krasner SS, Katz LA, Gudleski GD, Holroyd K: Self administered cognitive behavior therapy for moderate to severe IBS: clinical efficacy, tolerability, feasibility. Clin Gastroenterol Hepatol. 2008, 6: 899-906. 10.1016\/j.cgh.2008.03.004.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"937_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0016-5085(03)00669-3","volume":"125","author":"DA Drossman","year":"2003","unstructured":"Drossman DA, Toner BB, Whitehead WE, Diamant NE, Dalton CB, Duncan S: Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders. Gastroenterol. 2003, 125: 19-31. 10.1016\/S0016-5085(03)00669-3.","journal-title":"Gastroenterol"},{"key":"937_CR12","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/MEG.0b013e3282f2519d","volume":"20","author":"P McCrone","year":"2008","unstructured":"McCrone P, Knapp M, Kennedy T, Seed P, Jones R, Darnley S: Cost effectiveness of cognitive behaviour therapy in addition to mebeverine for irritable bowel syndrome. Eur J Gastroenterol Hepatol. 2008, 20: 255-263. 10.1097\/MEG.0b013e3282f2519d.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"937_CR13","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1192\/bjp.187.5.456","volume":"187","author":"G Andersson","year":"2005","unstructured":"Andersson G, Bergstrom J, Hollandare F, Carlbring P, Kaldo V, Ekselius L: Internet-based self-help for depression: randomised controlled trial. BJ Psychiatry. 2005, 187: 456-461. 10.1192\/bjp.187.5.456.","journal-title":"BJ Psychiatry"},{"key":"937_CR14","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1097\/01.PSY.0000031577.42041.F8","volume":"64","author":"G Andersson","year":"2002","unstructured":"Andersson G, Stromgren T, Strom L, Lyttkens L: Randomised controlled trail of internet-based cognitive behavioural therapy for distress associated with tinnitus. Psychosom Med. 2002, 64: 810-816. 10.1097\/01.PSY.0000031577.42041.F8.","journal-title":"Psychosom Med"},{"key":"937_CR15","doi-asserted-by":"publisher","first-page":"769","DOI":"10.5665\/sleep.1872","volume":"35","author":"CA Espie","year":"2012","unstructured":"Espie CA, Kyle SD, Williams C, Ong JC, Douglas NJ, Hames P: A randomised placebo-controlled trial of onlibe cognitive behavioural therapy for chronic insomnia disorder delivered via an automated media-rich web application. Sleep. 2012, 35: 769-781.","journal-title":"Sleep"},{"key":"937_CR16","volume-title":"Depression and Anxiety - Computerised Cognitive Behavioural Therapy (CCBT), TA97","author":"NICE","year":"2006","unstructured":"NICE: Depression and Anxiety - Computerised Cognitive Behavioural Therapy (CCBT), TA97. 2006, NICE, \n                    http:\/\/guidance.nice.org.uk\/TA97\n                    \n                  ,"},{"key":"937_CR17","doi-asserted-by":"publisher","first-page":"5861","DOI":"10.1016\/j.brat.2010.10.006","volume":"49","author":"B Ljotsson","year":"2011","unstructured":"Ljotsson B, Hedman E, Lindfors P, Hursti T, Lindefors N, Andersson G: Long-term follow-up of internet-delivered exposure and mindfulness based treatment for irritable bowel syndrome. Behav Res Ther. 2011, 49: 5861-","journal-title":"Behav Res Ther"},{"key":"937_CR18","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.brat.2009.05.002","volume":"47","author":"MG Hunt","year":"2009","unstructured":"Hunt MG, Moshier S, Milonova M: Brief cognitive-behavioral internet therapy for irritable bowel syndrome. Behav Res Ther. 2009, 47: 797-802. 10.1016\/j.brat.2009.05.002.","journal-title":"Behav Res Ther"},{"key":"937_CR19","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/1471-230X-10-136","volume":"10","author":"H Everitt","year":"2010","unstructured":"Everitt H, Moss-Morris R, Sibelli A, Tapp L, Coleman N, Yardley L: Management of Irritable Bowel Syndrome in Primary Care: Feasibility Randomised Controlled Trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website. (MIBS Trial). BMC Gastroenterol. 2010, 10: 136-10.1186\/1471-230X-10-136.","journal-title":"BMC Gastroenterol"},{"key":"937_CR20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1017\/S0033291709990195","volume":"40","author":"R Moss-Morris","year":"2010","unstructured":"Moss-Morris R, McAlpine L, Didsbury LP, Spence MJ: A randomised controlled trial of a cognitive behavioural therapy-based self-management intervention for irritable bowel syndrome in primary care. Psychol Med. 2010, 40: 94-","journal-title":"Psychol Med"},{"key":"937_CR21","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1472-6947-10-52","volume":"10","author":"Y Lucy","year":"2010","unstructured":"Lucy Y, Morrison LG, Panayiota A, Judith J, Paul L: Understanding reactions to an internet-delivered health-care intervention: accommodating user preferences for information provision. BMC Medical Informatics and Decision Making. 2010, 10: 52-10.1186\/1472-6947-10-52.","journal-title":"BMC Medical Informatics and Decision Making"},{"issue":"1","key":"937_CR22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1467-8535.2005.00521.x","volume":"37","author":"D Cotton","year":"2006","unstructured":"Cotton D, Gresty K: Reflecting on the think-aloud method for evaluating e learning. Br J Educ Technol. 2006, 37 (1): 45-54. 10.1111\/j.1467-8535.2005.00521.x.","journal-title":"Br J Educ Technol"},{"key":"937_CR23","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.2196\/jmir.1599","volume":"12","author":"L Yardley","year":"2010","unstructured":"Yardley L, Joseph J, Michie S, Weal M, Wills G, Little P: Evaluation of a web-based intervention providing tailored advice for self-management of minor respiratory symptoms: exploratory randomized controlled trial. J Med Internet Res. 2010, 12: e66-10.2196\/jmir.1599.","journal-title":"J Med Internet Res"},{"key":"937_CR24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1046\/j.1365-2036.1997.142318000.x","volume":"11","author":"CY Francis","year":"1997","unstructured":"Francis CY, Morris J, Whorwell PJ: The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther. 1997, 11: 395-402. 10.1046\/j.1365-2036.1997.142318000.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"937_CR25","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1023\/A:1018831127942","volume":"43","author":"DL Patrick","year":"1998","unstructured":"Patrick DL, Drossman DA, Frederick IO: Quality of life in persons with irritable bowel syndrome. Development and validation of a new measure. Dig Dis Sci. 1998, 43: 400-411. 10.1023\/A:1018831127942.","journal-title":"Dig Dis Sci"},{"issue":"4","key":"937_CR26","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/j.1572-0241.2000.01941.x","volume":"94","author":"DA Drossman","year":"2000","unstructured":"Drossman DA, Patrick DL, Whitehead WE, Toner BB, Diamant NE, Hu Y: Further validation of the IBS-QOL: a disease-specific quality-of-life questionnaire. Am J Gastroenterol. 2000, 94 (4): 999-1007.","journal-title":"Am J Gastroenterol"},{"key":"937_CR27","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/fampra\/15.2.165","volume":"15","author":"JGR Howie","year":"1998","unstructured":"Howie JGR, Heaney DJ, Maxwell M, Walker JJ: A comparison of a Patient Enablement Instrument (PEI) against two established satisfaction scales as an outcome measure of primary care consultations. Fam Pract. 1998, 15: 165-171. 10.1093\/fampra\/15.2.165.","journal-title":"Fam Pract"},{"key":"937_CR28","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S0895-4356(03)00027-1","volume":"56","author":"S Muller-Lissner","year":"2003","unstructured":"Muller-Lissner S, Koch G, Talley NJ, Drossman D, Rueegg P, Dunger-Baldauf C: Subject's global assessment of relief: an appropriate method to assess the impact of treatment on irritable bowel syndrome-related symptoms in clinical trials. J Clin Epidemiol. 2003, 56: 310-316. 10.1016\/S0895-4356(03)00027-1.","journal-title":"J Clin Epidemiol"},{"key":"937_CR29","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","volume":"67","author":"AS Zigmond","year":"1983","unstructured":"Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatrica Scandinavia. 1983, 67: 361-370. 10.1111\/j.1600-0447.1983.tb09716.x.","journal-title":"Acta Psychiatrica Scandinavia"},{"key":"937_CR30","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.brat.2010.03.003","volume":"48","author":"B Ljotsson","year":"2010","unstructured":"Ljotsson B, Falk L, Vesterlund AW, Hedman E, Linfors P, Ruck C: Internet-delivered exposure and mindfulness based therapy for irritable bowel syndrome\u2013a randomized controlled trial. Behav Res Ther. 2010, 48: 531-539. 10.1016\/j.brat.2010.03.003.","journal-title":"Behav Res Ther"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-230X-13-68\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-13-68.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-13-68","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-13-68.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T08:42:47Z","timestamp":1548146567000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/1471-230X-13-68"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,21]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["937"],"URL":"https:\/\/doi.org\/10.1186\/1471-230x-13-68","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,21]]},"article-number":"68"}}