{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T10:19:07Z","timestamp":1794651547474,"version":"4.9.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,3,10]],"date-time":"2006-03-10T00:00:00Z","timestamp":1141948800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Splanchnic vein thrombosis may complicate inherited thrombotic disorders. Acute cytomegalovirus infection is a rare cause of acquired venous thrombosis in the portal or mesenteric territory, but has never been described extending into a main hepatic vein.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 36-year-old immunocompetent woman presented with acute primary cytomegalovirus infection in association with extensive thrombosis in the portal and splenic vein. In addition, a fresh thrombus was evident in the right hepatic vein. A thorough evaluation for a hypercoagulable state was negative. The clinical course, biological evolution, radiological and histological findings were consistent with cytomegalovirus hepatitis complicated by a partial acute Budd-Chiari syndrome and portal thrombosis. Therapeutic anticoagulation was associated with a slow clinical improvement and partial vascular recanalization.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We described in details a new association between cytomegalovirus infection and acute venous thrombosis both in the portal vein and in the right hepatic vein, realizing a partial Budd-Chiari syndrome. One should be aware that this rare thrombotic event may be complicated by partial venous outflow block.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-230x-6-10","type":"journal-article","created":{"date-parts":[[2006,3,10]],"date-time":"2006-03-10T19:20:51Z","timestamp":1142018451000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary infection: a case report"],"prefix":"10.1186","volume":"6","author":[{"given":"Laurent","family":"Spahr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Cerny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Morard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rubbia-Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Schrenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,3,10]]},"reference":[{"issue":"4","key":"154_CR1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1136\/jcp.48.4.351","volume":"48","author":"F Colina","year":"1995","unstructured":"Colina F, Juca NT, Moreno E, Ballestin C, Farina J, Nevado M, Lumbreras C, Gomez-Sanz R: Histological diagnosis of cytomegalovirus hepatitis in liver allografts. J Clin Pathol. 1995, 48 (4): 351-357.","journal-title":"J Clin Pathol"},{"issue":"5","key":"154_CR2","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","volume":"31","author":"F Alvarez","year":"1999","unstructured":"Alvarez F, Berg PA, Bianchi FB, Bianchi L, Burroughs AK, Cancado EL, Chapman RW, Cooksley WG, Czaja AJ, Desmet VJ, Donaldson PT, Eddleston AL, Fainboim L, Heathcote J, Homberg JC, Hoofnagle JH, Kakumu S, Krawitt EL, Mackay IR, MacSween RN, Maddrey WC, Manns MP, McFarlane IG, Meyer zum Buschenfelde KH, Zeniya M, et al: International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999, 31 (5): 929-938. 10.1016\/S0168-8278(99)80297-9.","journal-title":"J Hepatol"},{"issue":"1","key":"154_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/00042737-200501000-00007","volume":"17","author":"V Bogin","year":"2005","unstructured":"Bogin V, Marcos A, Shaw-Stiffel T: Budd-Chiari syndrome: in evolution. Eur J Gastroenterol Hepatol. 2005, 17 (1): 33-35. 10.1097\/00042737-200501000-00007.","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"1","key":"154_CR4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1093\/clinids\/24.1.52","volume":"24","author":"M Eddleston","year":"1997","unstructured":"Eddleston M, Peacock S, Juniper M, Warrell DA: Severe cytomegalovirus infection in immunocompetent patients. Clin Infect Dis. 1997, 24 (1): 52-56.","journal-title":"Clin Infect Dis"},{"issue":"11","key":"154_CR5","doi-asserted-by":"publisher","first-page":"E134","DOI":"10.1086\/374664","volume":"36","author":"P Abgueguen","year":"2003","unstructured":"Abgueguen P, Delbos V, Chennebault JM, Payan C, Pichard E: Vascular thrombosis and acute cytomegalovirus infection in immunocompetent patients: report of 2 cases and literature review. Clin Infect Dis. 2003, 36 (11): E134-9. 10.1086\/374664.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"154_CR6","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1067\/msy.2003.8","volume":"133","author":"S Benoist","year":"2003","unstructured":"Benoist S, Laisne MJ, Joly F, Boudiaf M, Panis Y, Valleur P: Cytomegalovirus infection as a cause of acute superior mesenteric vein thrombosis with jejunal infarction. Surgery. 2003, 133 (2): 222-223. 10.1067\/msy.2003.8.","journal-title":"Surgery"},{"issue":"4","key":"154_CR7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1440-1746.1997.tb00423.x","volume":"12","author":"C Inacio","year":"1997","unstructured":"Inacio C, Hillaire S, Valla D, Denninger MH, Casadevall N, Erlinger S: Case report: cytomegalovirus infection as a cause of acute portal vein thrombosis. J Gastroenterol Hepatol. 1997, 12 (4): 287-288.","journal-title":"J Gastroenterol Hepatol"},{"issue":"5","key":"154_CR8","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/00001721-200307000-00010","volume":"14","author":"F Bauduer","year":"2003","unstructured":"Bauduer F, Blanc A, Cordon B: Deep vein thrombosis and acute cytomegalovirus infection: case report and review of the literature. Blood Coagul Fibrinolysis. 2003, 14 (5): 489-491. 10.1097\/00001721-200307000-00010.","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"4","key":"154_CR9","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1097\/01.TP.0000148239.00384.F0","volume":"79","author":"AT Rowshani","year":"2005","unstructured":"Rowshani AT, Bemelman FJ, van Leeuwen EM, van Lier RA, ten Berge IJ: Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients. Transplantation. 2005, 79 (4): 381-386. 10.1097\/01.TP.0000148239.00384.F0.","journal-title":"Transplantation"},{"issue":"5","key":"154_CR10","first-page":"353","volume":"138","author":"M Bentata-Pessayre","year":"1987","unstructured":"Bentata-Pessayre M, Beaugrand M, Callard P, Brun-Vesinet F, Krivitsky A, Mornet P, Delzant G: [Granulomatous hepatitis in cytomegalovirus infection in healthy adults]. Ann Med Interne (Paris). 1987, 138 (5): 353-357.","journal-title":"Ann Med Interne (Paris)"},{"issue":"1","key":"154_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1055\/s-2002-23202","volume":"22","author":"DC Valla","year":"2002","unstructured":"Valla DC: Hepatic vein thrombosis (Budd-Chiari syndrome). Semin Liver Dis. 2002, 22 (1): 5-14. 10.1055\/s-2002-23202.","journal-title":"Semin Liver Dis"},{"issue":"3","key":"154_CR12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1055\/s-0038-1656381","volume":"68","author":"MC van Dam-Mieras","year":"1992","unstructured":"van Dam-Mieras MC, Muller AD, van Hinsbergh VW, Mullers WJ, Bomans PH, Bruggeman CA: The procoagulant response of cytomegalovirus infected endothelial cells. Thromb Haemost. 1992, 68 (3): 364-370.","journal-title":"Thromb Haemost"},{"issue":"6","key":"154_CR13","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1097\/00007890-200003270-00027","volume":"69","author":"CM Cebulla","year":"2000","unstructured":"Cebulla CM, Miller DM, Knight DA, Briggs BR, McGaughy V, Sedmak DD: Cytomegalovirus induces sialyl Lewis(x) and Lewis(x) on human endothelial cells. Transplantation. 2000, 69 (6): 1202-1209. 10.1097\/00007890-200003270-00027.","journal-title":"Transplantation"},{"issue":"3","key":"154_CR14","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/j.1365-2362.1991.tb01378.x","volume":"21","author":"AH Span","year":"1991","unstructured":"Span AH, van Dam-Mieras MC, Mullers W, Endert J, Muller AD, Bruggeman CA: The effect of virus infection on the adherence of leukocytes or platelets to endothelial cells. Eur J Clin Invest. 1991, 21 (3): 331-338.","journal-title":"Eur J Clin Invest"},{"key":"154_CR15","first-page":"S3","volume":"9 Suppl 2","author":"GM Vercellotti","year":"1998","unstructured":"Vercellotti GM: Effects of viral activation of the vessel wall on inflammation and thrombosis. Blood Coagul Fibrinolysis. 1998, 9 Suppl 2: S3-6.","journal-title":"Blood Coagul Fibrinolysis"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-6-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-230X-6-10\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-6-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-6-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T21:50:27Z","timestamp":1630446627000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/1471-230X-6-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,10]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["154"],"URL":"https:\/\/doi.org\/10.1186\/1471-230x-6-10","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,10]]},"assertion":[{"value":"13 October 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"10"}}