{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T15:44:18Z","timestamp":1726847058046},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Achalasia is a well-characterized esophageal motor disorder but the rarity of the disease limits performing large studies on its demographic and clinical features.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Prospectively, 213 achalasia patients (110 men and 103 women) were enrolled in the study. The diagnosis established by clinical, radiographic, and endoscopic as well as manometry criteria. All patients underwent a pre-designed clinical evaluation before and within 6 months after the treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Solid dysphagia was the most common clinical symptom in men and women. Chest pain was the only symptom which was significantly different between two groups and was more complained by women than men (70.9% vs. 54.5% P value= 0.03). Although the occurrence of chest pain significantly reduced after treatment in both groups (P &lt; 0.001), it was still higher among women (32% vs. 20.9% P value= 0.04). In both sexes, chest pain did not relate to the symptom duration, LES pressure and type of treatment patients received. Also no significant relation was found between chest pain and other symptoms expressed by men and women before and after treatment. Chest pain was less frequently reported by patients over 56 yrs of age in comparison to those less than 56 yrs (p &lt; 0.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>It seems that chest pain is the distinct symptom of achalasia which is affected by sex as well as age and does not relate to the duration of illness, LESP and the type of treatment achalasia patients receive.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-230x-6-12","type":"journal-article","created":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T13:56:45Z","timestamp":1145455005000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Gender effect on clinical features of achalasia: a prospective study"],"prefix":"10.1186","volume":"6","author":[{"given":"Javad","family":"Mikaeli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farnoosh","family":"Farrokhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faraz","family":"Bishehsari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboobeh","family":"Mahdavinia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Malekzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"156_CR1","first-page":"577","volume-title":"Sleisenger & fordtran's Gastrointestinal and liver disease","author":"DN Clouse R","year":"2002","unstructured":"Clouse R DN: Esophageal motor and sensory function and motor disorders of the esophagus. Sleisenger & fordtran's Gastrointestinal and liver disease. Edited by: Feldman M SBFSMHFJS. 2002, Philadelphia, Saunders, 577-578. 7th ed,","edition":"7th ed,"},{"key":"156_CR2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1056\/NEJM197907263010404","volume":"301","author":"S Cohen","year":"1979","unstructured":"Cohen S: Motor disorders of the esophagus. N Engl J Med. 1979, 301: 184-192.","journal-title":"N Engl J Med"},{"key":"156_CR3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0016-5085(80)90090-6","volume":"79","author":"G Vantrappen","year":"1980","unstructured":"Vantrappen G, Hellemans J: Treatment of achalasia and related motor disorders. Gastroenterology. 1980, 79: 144-154.","journal-title":"Gastroenterology"},{"key":"156_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000171617","volume":"15 Suppl 1:1-27","author":"S Birgisson","year":"1997","unstructured":"Birgisson S, Richter JE: Achalasia: what's new in diagnosis and treatment?. Dig Dis. 1997, 15 Suppl 1:1-27.: 1-27.","journal-title":"Dig Dis"},{"key":"156_CR5","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1136\/gut.33.8.1011","volume":"33","author":"PJ Howard","year":"1992","unstructured":"Howard PJ, Maher L, Pryde A, Cameron EW, Heading RC: Five year prospective study of the incidence, clinical features, and diagnosis of achalasia in Edinburgh. Gut. 1992, 33: 1011-1015.","journal-title":"Gut"},{"key":"156_CR6","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.3109\/00365529709028145","volume":"32","author":"M Papo","year":"1997","unstructured":"Papo M, Mearin F, Castro A, Armengol JR, Malagelada JR: Chest pain and reappearance of esophageal peristalsis in treated achalasia. Scand J Gastroenterol. 1997, 32: 1190-1194.","journal-title":"Scand J Gastroenterol"},{"key":"156_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/00004836-199807000-00006","volume":"27","author":"MF Vaezi","year":"1998","unstructured":"Vaezi MF, Richter JE: Current therapies for achalasia: comparison and efficacy. J Clin Gastroenterol. 1998, 27: 21-35. 10.1097\/00004836-199807000-00006.","journal-title":"J Clin Gastroenterol"},{"key":"156_CR8","volume-title":"Up To Date","author":"SJ Spechler","year":"2005","unstructured":"Spechler SJ: Clinical manifestations of achalasia. Up To Date. Edited by: Rose BDE. 2005, Wellesley, MA, Up To Date"},{"key":"156_CR9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1590\/S0100-879X1998000400011","volume":"31","author":"RO Dantas","year":"1998","unstructured":"Dantas RO, Ferriolli E, Souza MA: Gender effects on esophageal motility. Braz J Med Biol Res. 1998, 31: 539-544. 10.1590\/S0100-879X1998000400011.","journal-title":"Braz J Med Biol Res"},{"key":"156_CR10","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.1365-2036.2004.02080.x","volume":"20","author":"J Mikaeli","year":"2004","unstructured":"Mikaeli J, Bishehsari F, Montazeri G, Yaghoobi M, Malekzadeh R: Pneumatic balloon dilatation in achalasia: a prospective comparison of safety and efficacy with different balloon diameters. Aliment Pharmacol Ther. 2004, 20: 431-6. 10.1046\/j.1365-2036.2001.01065.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"156_CR11","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1572-0241.2003.07266.x","volume":"98","author":"M Yaghoobi","year":"2003","unstructured":"Yaghoobi M, Mikaeli J, Montazeri G, Nouri N, Sohrabi MR, Malekzadeh R: Correlation between clinical severity score and the lower esophageal sphincter relaxation pressure in idiopathic achalasia. Am J Gastroenterol. 2003, 98: 278-283. 10.1111\/j.1572-0241.2003.07266.x.","journal-title":"Am J Gastroenterol"},{"key":"156_CR12","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1046\/j.1365-2036.1999.00602.x","volume":"13","author":"V Annese","year":"1999","unstructured":"Annese V, Bassotti G, Coccia G, D'onofrio V, Gatto G, Repici A, Andriulli A: Comparison of two different formulations of botulinum toxin A for the treatment of oesophageal achalasia. The Gismad Achalasia Study Group. Aliment Pharmacol Ther. 1999, 13: 1347-1350. 10.1046\/j.1365-2036.1999.00602.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"156_CR13","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/BF01300761","volume":"36","author":"RE Clouse","year":"1991","unstructured":"Clouse RE, Abramson BK, Todorczuk JR: Achalasia in the elderly. Effects of aging on clinical presentation and outcome. Dig Dis Sci. 1991, 36: 225-228. 10.1007\/BF01300761.","journal-title":"Dig Dis Sci"},{"key":"156_CR14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/00042737-200102000-00006","volume":"13","author":"L d'Alteroche","year":"2001","unstructured":"d'Alteroche L, Oung C, Fourquet F, Picon L, Lagasse JP, Metman EH: Evolution of clinical and radiological features at diagnosis of achalasia during a 19-year period in central France. Eur J Gastroenterol Hepatol. 2001, 13: 121-126. 10.1097\/00042737-200102000-00006.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"156_CR15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/000313480507100512","volume":"71","author":"S Rakita","year":"2005","unstructured":"Rakita S, Bloomston M, Villadolid D, Thometz D, Boe B, Rosemurgy A: Age affects presenting symptoms of achalasia and outcomes after myotomy. Am Surg. 2005, 71: 424-429.","journal-title":"Am Surg"},{"key":"156_CR16","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/S0016-5085(99)70493-2","volume":"116","author":"VF Eckardt","year":"1999","unstructured":"Eckardt VF, Stauf B, Bernhard G: Chest pain in achalasia: patient characteristics and clinical course. Gastroenterology. 1999, 116: 1300-1304. 10.1016\/S0016-5085(99)70493-2.","journal-title":"Gastroenterology"},{"key":"156_CR17","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/S0277-9536(00)00269-0","volume":"52","author":"S Philpott","year":"2001","unstructured":"Philpott S, Boynton PM, Feder G, Hemingway H: Gender differences in descriptions of angina symptoms and health problems immediately prior to angiography: the ACRE study. Appropriateness of Coronary Revascularisation study. Soc Sci Med. 2001, 52: 1565-1575. 10.1016\/S0277-9536(00)00269-0.","journal-title":"Soc Sci Med"},{"key":"156_CR18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0304-3959(95)00214-6","volume":"65","author":"AM Unruh","year":"1996","unstructured":"Unruh AM: Gender variations in clinical pain experience. Pain. 1996, 65: 123-167. 10.1016\/0304-3959(95)00214-6.","journal-title":"Pain"},{"key":"156_CR19","first-page":"101","volume":"84","author":"DB Simmons","year":"1997","unstructured":"Simmons DB, Schuman BM, Griffin JWJ: Achalasia in patients over 65. J Fla Med Assoc. 1997, 84: 101-103.","journal-title":"J Fla Med Assoc"},{"key":"156_CR20","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/j.1572-0241.1998.210_a.x","volume":"93","author":"AC Ribeiro","year":"1998","unstructured":"Ribeiro AC, Klingler PJ, Hinder RA, DeVault K: Esophageal manometry: a comparison of findings in younger and older patients. Am J Gastroenterol. 1998, 93: 706-710. 10.1111\/j.1572-0241.1998.210_a.x.","journal-title":"Am J Gastroenterol"},{"key":"156_CR21","first-page":"332","volume":"101","author":"IR Lai","year":"2002","unstructured":"Lai IR, Lee WJ, Huang MT: Laparoscopic Heller myotomy with fundoplication for achalasia. J Formos Med Assoc. 2002, 101: 332-336.","journal-title":"J Formos Med Assoc"},{"key":"156_CR22","first-page":"970","volume":"83","author":"HS Shabsin","year":"1988","unstructured":"Shabsin HS, Katz PO, Schuster MM: Behavioral treatment of intractable chest pain in a patient with vigorous achalasia. Am J Gastroenterol. 1988, 83: 970-973.","journal-title":"Am J Gastroenterol"},{"key":"156_CR23","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1056\/NEJM198312013092201","volume":"309","author":"RE Clouse","year":"1983","unstructured":"Clouse RE, Lustman PJ: Psychiatric illness and contraction abnormalities of the esophagus. N Engl J Med. 1983, 309: 1337-1342.","journal-title":"N Engl J Med"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-6-12.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-230X-6-12\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-6-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-230X-6-12.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T21:44:56Z","timestamp":1630446296000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/1471-230X-6-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["156"],"URL":"https:\/\/doi.org\/10.1186\/1471-230x-6-12","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,1]]},"assertion":[{"value":"15 November 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"12"}}