{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:25:27Z","timestamp":1791109527838,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T00:00:00Z","timestamp":1224892800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The prevalence of <jats:italic>H. pylori<\/jats:italic> is as high as 60\u201370% in Chinese population. Although duodenal ulcer and gastric cancer are both caused by <jats:italic>H. pylori<\/jats:italic>, they are at opposite ends of the spectrum and as such are considered mutually exclusive. Duodenal ulcer promoting (<jats:italic>dupA<\/jats:italic>) gene was reported to be associated with duodenal ulcer development. The aim of this study was to determine the prevalence of <jats:italic>dupA<\/jats:italic> gene of <jats:italic>Helicobacter pylori<\/jats:italic> in patients with various gastroduodenal diseases and to explore the association between the gene and other virulence factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>\n              <jats:italic>H. pylori<\/jats:italic> were isolated from gastric biopsies of patients with chronic gastritis, duodenal ulcer (DU), gastric ulcer (GU), or non-cardia gastric carcinoma. The <jats:italic>dupA<\/jats:italic>, <jats:italic>cagA<\/jats:italic>, <jats:italic>vacA<\/jats:italic>, <jats:italic>iceA<\/jats:italic> and <jats:italic>babA2<\/jats:italic> genotypes were determined by polymerase chain reaction. Histological features of gastric mucosal biopsy specimens were graded based on the scoring system proposed by the updated Sydney system. IL-1\u03b2 polymorphism was investigated using restriction fragment length polymorphism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Isolates from 360 patients including 133 with chronic gastritis, 101 with DU, 47 with GU, and 79 with non-cardia gastric carcinoma were examined. The <jats:italic>dupA<\/jats:italic> gene was detected in 35.3% (127\/360) and the prevalence DU patients was significantly greater than that in gastric cancer or GU patients (45.5% vs. 24.1% and 23.4%, <jats:italic>P<\/jats:italic> &lt; 0.05). Patients infected with <jats:italic>dupA<\/jats:italic>-positive strains had higher scores for chronic inflammation compared to those with <jats:italic>dupA<\/jats:italic>-negative strains (2.36 vs. 2.24, p = 0.058). The presence of <jats:italic>dupA<\/jats:italic> was not associated with the <jats:italic>cagA<\/jats:italic>, <jats:italic>vacA, iceA<\/jats:italic> and <jats:italic>babA 2<\/jats:italic> genotypes or with IL-1\u03b2 polymorphisms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In China the prevalence of <jats:italic>dupA<\/jats:italic> gene was highest in DU and inversely related to GU and gastric cancer.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-230x-8-49","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T06:13:25Z","timestamp":1224915205000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["The Helicobacter pylori duodenal ulcer promoting gene, dupAin China"],"prefix":"10.1186","volume":"8","author":[{"given":"Zhiyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,10,25]]},"reference":[{"key":"282_CR1","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1046\/j.1523-5378.2000.0050S1003.x","volume":"5","author":"DY Graham","year":"2000","unstructured":"Graham DY, Yamaoka Y: Disease-specific Helicobacter pylori virulence factors: the unfulfilled promise. 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