{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:24:17Z","timestamp":1761863057323},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>To examine the clinical characteristics of bacterial meningitis in elderly patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>261 patients with adult bacterial meningitis (ABM), collected during a study period of 11 years (2000-2010), were included for study. Among them, 87 patients aged \u2265 65 years and were classified as the elderly group. The clinical and laboratory characteristics and prognostic factors were analyzed, and a clinical comparison with those of non-elderly ABM patients was also made.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The 87 elderly ABM patients were composed of 53 males and 34 females, aged 65-87 years old (median = 71 years). Diabetes mellitus (DM) was the most common underlying condition (34%), followed by end stage renal disease (7%), alcoholism (4%) and malignancies (4%). Fever was the most common clinical manifestation (86%), followed by altered consciousness (62%), leukocytosis (53%), hydrocephalus (38%), seizure (30%), bacteremia (21%) and shock (11%). Thirty-nine of these 87 elderly ABM patients had spontaneous infection, while the other 48 had post-neurosurgical infection. Forty-four patients contracted ABM in a community-acquired state, while the other 43, a nosocomial state. The therapeutic results of the 87 elderly ABM patients were that 34 patients expired and 53 patients survived. The comparative results of the clinical and laboratory characteristics between the elderly and non-elderly ABM patients showed that only peripheral blood leukocytosis was significant. Presence of shock and seizure were significant prognostic factors of elderly ABM patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Elderly ABM patients accounted for 34.8% of the overall ABM cases, and this relatively high incidence rate may signify the future burden of ABM in the elderly population in Taiwan. The relative frequency of implicated pathogens of elderly ABM is similar to that of non-elderly ABM. Compared with non-elderly patients, the elderly ABM patients have a significantly lower incidence of peripheral blood leukocytosis. The mortality rate of elderly ABM remains high, and the presence of shock and seizures are important prognostic factors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2318-11-91","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T20:03:00Z","timestamp":1325102580000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Clinical characteristics and prognosis of acute bacterial meningitis in elderly patients over 65: a hospital-based study"],"prefix":"10.1186","volume":"11","author":[{"given":"Wei-An","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-Wen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiung-Chih","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Neng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hsien","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Chung","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chih","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Ren","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"731_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S1473-3099(07)70050-6","volume":"7","author":"MT Fitch","year":"2007","unstructured":"Fitch MT, van de Beek D: Emergency diagnosis and treatment of adult meningitis. Lancet Infect Dis. 2007, 7: 191-200. 10.1016\/S1473-3099(07)70050-6.","journal-title":"Lancet Infect Dis"},{"key":"731_CR2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/MD.0b013e31819d50ef","volume":"88","author":"C Cabellos","year":"2009","unstructured":"Cabellos C, Verdaguer R, Olmo M, Fern\u00e1ndez-Sab\u00e9 N, Cisnal M, Ariza J, Gudiol F, Viladrich PF: Community-acquired bacterial meningitis in elderly patients: experience over 30 years. Medicine (Baltimore). 2009, 88: 115-119. 10.1097\/MD.0b013e31819d50ef.","journal-title":"Medicine (Baltimore)"},{"key":"731_CR3","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1111\/j.1532-5415.2006.00878.x","volume":"54","author":"M Weisfelt","year":"2006","unstructured":"Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J: Community-acquired bacterial meningitis in older people. J Am Geriatr Soc. 2006, 54: 1500-1507. 10.1111\/j.1532-5415.2006.00878.x.","journal-title":"J Am Geriatr Soc"},{"key":"731_CR4","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1111\/j.1469-0691.2009.03039.x","volume":"16","author":"H Erdem","year":"2010","unstructured":"Erdem H, Kilic S, Coskun O, Ersoy Y, Cagatay A, Onguru P, Alp S, Members of the Turkish Bacterial Meningitis in the Elderly Study Group: Community-acquired acute bacterial meningitis in the elderly in Turkey. Clin Microbiol Infect. 2010, 16: 1223-1229.","journal-title":"Clin Microbiol Infect"},{"key":"731_CR5","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1056\/NEJMoa1005384","volume":"364","author":"MC Thigpen","year":"2011","unstructured":"Thigpen MC, Whitney CG, Messonnier NE, Zell ER, Lynfield R, Hadler JL, Harrison LH, Farley MM, Reingold A, Bennett NM, Craig AS, Schaffner W, Thomas A, Lewis MM, Scallan E, Schuchat A, Emerging Infections Programs Network: Bacterial meningitis in the United States, 1998-2007. N Engl J Med. 2011, 364: 2016-2025. 10.1056\/NEJMoa1005384.","journal-title":"N Engl J Med"},{"key":"731_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1056\/NEJM199301073280104","volume":"328","author":"ML Durand","year":"1993","unstructured":"Durand ML, Calderwood SB, Weber DJ, Miller SI, Southwick FS, Caviness VS, Swartz MN: Acute bacterial meningitis in adults. A review of 493 episodes. N Engl J Med. 1993, 328: 21-28. 10.1056\/NEJM199301073280104.","journal-title":"N Engl J Med"},{"key":"731_CR7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s15010-007-7009-8","volume":"36","author":"WN Chang","year":"2008","unstructured":"Chang WN, Lu CH, Huang CR, Tsai NW, Chuang YC, Chang CC, Chen SF, Chien CC: Changing epidemiology of adult bacterial meningitis in southern Taiwan: a hospital-based study. Infection. 2008, 36: 15-22. 10.1007\/s15010-007-7009-8.","journal-title":"Infection"},{"key":"731_CR8","doi-asserted-by":"crossref","unstructured":"Neupane B, Walter SD, Krueger P, Marrie T, Loeb M: Predictors of inhospital mortality and re-hospitalization in older adults with community-acquired pneumonia: a prospective cohort study. BMC Geriatr. 2010, 10 (22):","DOI":"10.1186\/1471-2318-10-22"},{"key":"731_CR9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s150100050003","volume":"28","author":"WN Chang","year":"2000","unstructured":"Chang WN, Lu CH, Huang CR, Chuang YC: Mixed infection in adult bacterial meningitis. Infection. 2000, 28: 8-12. 10.1007\/s150100050003.","journal-title":"Infection"},{"key":"731_CR10","unstructured":"Department of Health, Executive Yuan, Taiwan, [http:\/\/www.doh.gov.tw]"},{"key":"731_CR11","doi-asserted-by":"publisher","first-page":"395","DOI":"10.7326\/0003-4819-98-3-395","volume":"98","author":"EL Schneider","year":"1983","unstructured":"Schneider EL: Infectious diseases in the elderly. Ann Intern Med. 1983, 98: 395-400.","journal-title":"Ann Intern Med"},{"issue":"Suppl 1","key":"731_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0002-9343(86)90514-0","volume":"82","author":"RA Garibaldi","year":"1986","unstructured":"Garibaldi RA, Nurse BA: Infections in the elderly. Am J Med. 1986, 82 (Suppl 1): 53-58.","journal-title":"Am J Med"},{"key":"731_CR13","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1159\/000193996","volume":"55","author":"R Bellmann-Weiler","year":"2009","unstructured":"Bellmann-Weiler R, Weiss G: Pitfalls in the diagnosis and therapy of infections in elderly patients - A mini-review. Gerontology. 2009, 55: 241-249. 10.1159\/000193996.","journal-title":"Gerontology"},{"key":"731_CR14","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/SHK.0b013e318067da56","volume":"86","author":"CC Lee","year":"2007","unstructured":"Lee CC, Chen SY, Chang IJ, Chen SC, Wu SC: Comparison of clinical manifestations and outcome of community-acquired bloodstream infections among the oldest old, elderly, and adults patients. Medicine. 2007, 86: 138-144. 10.1097\/SHK.0b013e318067da56.","journal-title":"Medicine"},{"key":"731_CR15","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1093\/jjco\/hyq057","volume":"40","author":"CJ Chiang","year":"2010","unstructured":"Chiang CJ, Chen YC, Chen CJ, You SL, Lai MS, Taiwan Cancer Registry Task Force: Cancer trends in Taiwan. Jpn J Clin Oncol. 2010, 40: 897-904. 10.1093\/jjco\/hyq057.","journal-title":"Jpn J Clin Oncol"},{"key":"731_CR16","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/jjco\/hyg092","volume":"33","author":"MT Liu","year":"2003","unstructured":"Liu MT, Hsieh CY, Chang TH, Huang CC, Wang AY: Prognostic factors affecting the outcome of nasopharyngeal carcinoma. Jpn J clin Oncol. 2003, 33: 501-8. 10.1093\/jjco\/hyg092.","journal-title":"Jpn J clin Oncol"},{"key":"731_CR17","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s10096-003-0965-8","volume":"22","author":"CR Huang","year":"2003","unstructured":"Huang CR, Lu CH, Chien CC, Lee PY, Chang WN: High incidence of Gram-negative bacillary infection and high mortality in adult patients with bacterial meningitis and nasopharyngeal carcinoma. Eur J Clin Microbiol Infect Dis. 2003, 22: 509-511. 10.1007\/s10096-003-0965-8.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"731_CR18","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s15010-002-3010-4","volume":"30","author":"CR Huang","year":"2002","unstructured":"Huang CR, Lu CH, Chang HW, Lee PY, Lin MW, Chang WN: Community-acquired spontaneous bacterial meningitis in adult diabetic patients: an analysis of clinical characteristics and prognostic factors. Infection. 2002, 30: 346-350. 10.1007\/s15010-002-3010-4.","journal-title":"Infection"},{"key":"731_CR19","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/ajg.2009.586","volume":"105","author":"NP Foo","year":"2010","unstructured":"Foo NP, Chen KT, Lin HJ, Guo HR: Characteristics of pyogenic liver abscess patients with and without diabetes mellitus. Am J Gastroenterol. 2010, 105: 328-335. 10.1038\/ajg.2009.586.","journal-title":"Am J Gastroenterol"},{"key":"731_CR20","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1212\/01.wnl.0000288178.91614.5d","volume":"27","author":"E Zoons","year":"2008","unstructured":"Zoons E, Weisfelt M, de Gans J, Spanjaard L, Koelman JH, Reitsma JB, van de Beek D: Seizures in adults with bacterial meningitis. Neurology. 2008, 27: 2109-2115.","journal-title":"Neurology"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-11-91.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2318-11-91\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-11-91","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-11-91.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T18:12:16Z","timestamp":1630519936000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/1471-2318-11-91"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["731"],"URL":"https:\/\/doi.org\/10.1186\/1471-2318-11-91","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"8 September 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"91"}}