{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:25:33Z","timestamp":1763036733129},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T00:00:00Z","timestamp":1352764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>An increased risk of venous thromboembolism has been reported in patients treated with non-steroidal anti-inflammatory drugs (NSAIDs). We describe a case of acute portal vein thrombosis (PVT) in a hepatitis C virus (HCV)-positive elderly patient following administration of indomethacin.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 79-year-old HCV-positive man was hospitalized for severe abdominal pain, nausea and vomiting, 15 days after starting indomethacin for back pain. Clinical signs and imaging evaluations disclosed a picture of PVT. Indomethacin was discontinued, and the patient was started on fondaparinux and antithrombin. He was discharged 15 days later due to improvement of his clinical conditions. Thirty days later, a follow-up ultrasound did not show appreciable signs of PVT. The time elapsing between the start of analgesic therapy and PVT onset suggests a role of indomethacin as the triggering agent. Indomethacin could have precipitated PVT by a combination of at least two detrimental mechanisms: 1) direct action on liver vascular endothelium by inhibition of prostacyclin biosynthesis; 2) damage to the intestinal mucosa, followed by inflammatory and pro-coagulant activation of portal endothelium upon exposure to bacterial endotoxins.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This case can be of interest to physicians, who should exert caution when prescribing NSAIDs for inflammatory pain in patients with background inflammatory dysfunctions of the portal vein endothelium.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2318-12-69","type":"journal-article","created":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T21:14:12Z","timestamp":1352841252000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient"],"prefix":"10.1186","volume":"12","author":[{"given":"Stefania","family":"Mantarro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Tuccori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pasqualetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Tognini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Montagnani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Monzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Blandizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,11,13]]},"reference":[{"key":"805_CR1","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1111\/j.1365-2036.2009.04116.x","volume":"30","author":"Y Chawla","year":"2009","unstructured":"Chawla Y, Duseja A, Dhiman RK: Review article: the modern management of portal vein thrombosis. Aliment Pharmacol Ther. 2009, 30: 881-94. 10.1111\/j.1365-2036.2009.04116.x.","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"805_CR2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.dld.2009.08.003","volume":"42","author":"M Primignani","year":"2010","unstructured":"Primignani M: Portal vein thrombosis, revisited. Dig Liver Dis. 2010, 42 (3): 163-70. 10.1016\/j.dld.2009.08.003.","journal-title":"Dig Liver Dis"},{"key":"805_CR3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3748\/wjg.v16.i2.143","volume":"16","author":"FR Ponziani","year":"2010","unstructured":"Ponziani FR, Zocco MA, Campanale C, Rinninella E, Tortora A, Di Maurizio L, Bombardieri G, De Cristofaro R, De Gaetano AM, Landolfi R, Gasbarrini A: Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment. World J Gastroenterol. 2010, 16: 143-55. 10.3748\/wjg.v16.i2.143.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"805_CR4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.atherosclerosis.2012.05.033","volume":"223","author":"G Mazzoccoli","year":"2012","unstructured":"Mazzoccoli G, Copetti M, Dagostino MP, Grilli M, Fontana A, Pellegrini F, Greco A: Epicardial adipose tissue and idiopathic deep venous thrombosis: An association study. Atherosclerosis. 2012, 223 (2): 378-83. 10.1016\/j.atherosclerosis.2012.05.033.","journal-title":"Atherosclerosis"},{"key":"805_CR5","first-page":"33","volume":"18","author":"EB Petcu","year":"2010","unstructured":"Petcu EB, Koelmeyer TD, Miroiu RI, Berman L, Ghiorghiu V, Opris MM: Fatal pulmonary embolism: a retrospective clinical study conducted in women aged between 18 to 45 years and review of the literature. Revista Romana De Medicina De Laborator. 2010, 18: 33-48.","journal-title":"Revista Romana De Medicina De Laborator"},{"key":"805_CR6","volume-title":"Int J Obes","author":"C Dellas","year":"2012","unstructured":"Dellas C, Lankeit M, Reiner C, Sch\u00e4fer K, Hasenfu\u00df G, Konstantinides S: BMI-independent inverse relationship of plasma leptin levels with outcome in patients with acute pulmonary embolism. Int J Obes. 2012, 10.1038\/ijo.2012.36. Epub ahead of print"},{"key":"805_CR7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/clpt.1981.154","volume":"30","author":"CA Naranjo","year":"1981","unstructured":"Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ: A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981, 30: 239-245. 10.1038\/clpt.1981.154.","journal-title":"Clin Pharmacol Ther"},{"key":"805_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s11739-008-0128-0","volume":"3","author":"FL Fimognari","year":"2008","unstructured":"Fimognari FL, Violi F: Portal vein thrombosis in liver cirrhosis. Intern Emerg Med. 2008, 3: 213-8. 10.1007\/s11739-008-0128-0.","journal-title":"Intern Emerg Med"},{"key":"805_CR9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ejim.2010.11.006","volume":"22","author":"D Justo","year":"2011","unstructured":"Justo D, Finn T, Atzmony L, Guy N, Steinvil A: Thrombosis associated with acute cytomegalovirus infection: a meta-analysis. Eur J Intern Med. 2011, 22: 195-9. 10.1016\/j.ejim.2010.11.006.","journal-title":"Eur J Intern Med"},{"issue":"9\u201312","key":"805_CR10","first-page":"583","volume":"53","author":"L Amitrano","year":"2007","unstructured":"Amitrano L, Guardascione MA, Ames PR: Coagulation abnormalities in cirrhotic patients with portal vein thrombosis. Clin Lab. 2007, 53 (9\u201312): 583-9.","journal-title":"Clin Lab"},{"key":"805_CR11","unstructured":"eHealthMe \u2013 Real world drug outcomes: http:\/\/www.ehealthme.com\/. Lastly accessed on July 2012"},{"key":"805_CR12","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1111\/j.1538-7836.2011.04354.x","volume":"9","author":"M Schmidt","year":"2011","unstructured":"Schmidt M, Christiansen CF, Horv\u00e1th-Puh\u00f3 E, Glynn RJ, Rothman KJ, S\u00f8rensen HT: Non-steroidal anti-inflammatory drug use and risk of venous thromboembolism. J Thromb Haemost. 2011, 9: 1326-33. 10.1111\/j.1538-7836.2011.04354.x.","journal-title":"J Thromb Haemost"},{"key":"805_CR13","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1002\/pds.2130","volume":"20","author":"S Biere-Rafi","year":"2011","unstructured":"Biere-Rafi S, Di Nisio M, Gerdes V, Porreca E, Souverein P, Boer A, B\u00fcller H, Kamphuisen P: Non-steroidal anti-inflammatory drugs and risk of pulmonary embolism. Pharmacoepidemiol Drug Saf. 2011, 20: 635-42. 10.1002\/pds.2130.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"805_CR14","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3109\/14767050903334877","volume":"23","author":"C Rebordosa","year":"2010","unstructured":"Rebordosa C, Zelop CM, Kogevinas M, S\u00f8rensen HT, Olsen J: Use of acetaminophen during pregnancy and risk of preeclampsia, hypertensive and vascular disorders: a birth cohort study. J Matern Fetal Neonatal Med. 2010, 23: 371-8. 10.3109\/14767050903334877.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"805_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3109\/00365529509093231","volume":"30","author":"G Nyg\u00e5rd","year":"1995","unstructured":"Nyg\u00e5rd G, Hudson M, Mazure G, Anthony A, Dhillon AP, Pounder RE, Wakefield AJ: Procoagulant and prothrombotic responses of human endothelium to indomethacin and endotoxin in vitro. Relevance to non-steroidal anti-inflammatory drug enteropathy. Scand J Gastroenterol. 1995, 30: 25-32. 10.3109\/00365529509093231.","journal-title":"Scand J Gastroenterol"},{"key":"805_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1159\/000097689","volume":"35","author":"FX Eizayaga","year":"2006","unstructured":"Eizayaga FX, Aguejouf O, Desplat V, Belon P, Doutremepuich C: Modifications produced by indomethacin and L-NAME in the effect of ultralow-dose aspirin on platelet activity in portal hypertension. Pathophysiol Haemost Thromb. 2006, 35: 357-63. 10.1159\/000097689.","journal-title":"Pathophysiol Haemost Thromb"},{"key":"805_CR17","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1099\/vir.0.81056-0","volume":"86","author":"A Balasubramanian","year":"2005","unstructured":"Balasubramanian A, Munshi N, Koziel MJ, Hu Z, Liang TJ, Groopman JE, Ganju RK: Structural proteins of Hepatitis C virus induce interleukin 8 production and apoptosis in human endothelial cells. J Gen Virol. 2005, 86: 3291-301. 10.1099\/vir.0.81056-0.","journal-title":"J Gen Virol"},{"key":"805_CR18","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1016\/0016-5085(93)90667-2","volume":"104","author":"I Bjarnason","year":"1993","unstructured":"Bjarnason I, Hayllar J, MacPherson AJ, Russell AS: Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology. 1993, 104: 1832-47.","journal-title":"Gastroenterology"},{"key":"805_CR19","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.gtc.2010.08.010","volume":"39","author":"C Scarpignato","year":"2010","unstructured":"Scarpignato C, Hunt RH: Nonsteroidal antiinflammatory drug-related injury to the gastrointestinal tract: clinical picture, pathogenesis, and prevention. Gastroenterol Clin North Am. 2010, 39: 433-64. 10.1016\/j.gtc.2010.08.010.","journal-title":"Gastroenterol Clin North Am"},{"key":"805_CR20","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.phrs.2008.11.004","volume":"59","author":"C Blandizzi","year":"2009","unstructured":"Blandizzi C, Tuccori M, Colucci R, Fornai M, Antonioli L, Ghisu N, Del Tacca M: Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy. Pharmacol Res. 2009, 59: 90-100. 10.1016\/j.phrs.2008.11.004.","journal-title":"Pharmacol Res"},{"key":"805_CR21","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.cca.2009.12.026","volume":"411","author":"K Takeuchi","year":"2010","unstructured":"Takeuchi K, Tanaka A, Kato S, Amagase K, Satoh H: Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage. Clin Chim Acta. 2010, 411: 459-66. 10.1016\/j.cca.2009.12.026.","journal-title":"Clin Chim Acta"},{"key":"805_CR22","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1053\/j.gastro.2008.07.067","volume":"135","author":"L Laine","year":"2008","unstructured":"Laine L, Curtis SP, Langman M, Jensen DM, Cryer B, Kaur A, Cannon CP: Lower gastrointestinal events in a double-blind trial of the cyclo-oxygenase-2 selective inhibitor etoricoxib and the traditional nonsteroidal anti-inflammatory drug diclofenac. Gastroenterology. 2008, 135: 1517-25. 10.1053\/j.gastro.2008.07.067.","journal-title":"Gastroenterology"},{"key":"805_CR23","volume-title":"Clinical and laboratory predictors of NSAID-induced enteropathy: a capsule endoscopy study","author":"I Tachec\u00ed","year":"2011","unstructured":"Tachec\u00ed I, Bradna P, Kopacova M, Rejchrt S, Bures J: 19th United European Gastroenterology Week. October 22\u201326, Stockholm. Clinical and laboratory predictors of NSAID-induced enteropathy: a capsule endoscopy study. 2011, (Abstract)"},{"key":"805_CR24","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1097\/00042737-200507000-00001","volume":"17","author":"R Srirajaskanthan","year":"2005","unstructured":"Srirajaskanthan R, Winter M, Muller AF: Venous thrombosis in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2005, 17: 697-700. 10.1097\/00042737-200507000-00001.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"805_CR25","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1097\/00005176-200003000-00022","volume":"30","author":"NC Prisi-Hauck","year":"2000","unstructured":"Prisi-Hauck NC, Foss HD, Baier J, Kurunczi S: Simultaneous occurrence of autoimmune enteropathy and recurrent deep venous thrombosis. J Pediatr Gastroenterol Nutrition. 2000, 30: 324-9. 10.1097\/00005176-200003000-00022.","journal-title":"J Pediatr Gastroenterol Nutrition"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-12-69.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2318-12-69\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-12-69","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-12-69.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T21:32:17Z","timestamp":1630531937000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/1471-2318-12-69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,13]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["805"],"URL":"https:\/\/doi.org\/10.1186\/1471-2318-12-69","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,13]]},"assertion":[{"value":"25 April 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"69"}}