{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:36:42Z","timestamp":1789393002328,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-2318-14-19","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T11:08:11Z","timestamp":1392203291000},"source":"Crossref","is-referenced-by-count":41,"title":["The treatment of hypertension in people with dementia: a systematic review of observational studies"],"prefix":"10.1186","volume":"14","author":[{"given":"Tomas J","family":"Welsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Gladman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"issue":"5","key":"956_CR1","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s11906-011-0215-x","volume":"13","author":"DL Cohen","year":"2011","unstructured":"Cohen DL, Townsend RR: Update on pathophysiology and treatment of hypertension in the elderly. Curr Hypertens Rep. 2011, 13 (5): 330-337. 10.1007\/s11906-011-0215-x.","journal-title":"Curr Hypertens Rep"},{"issue":"18","key":"956_CR2","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1056\/NEJMoa0801369","volume":"358","author":"NS Beckett","year":"2008","unstructured":"Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L, Dumitrascu D, Stoyanovsky V, Antikainen RL, Nikitin Y, Anderson C, et al: Treatment of hypertension in patients 80\u00a0years of age or older. N Engl J Med. 2008, 358 (18): 1887-1898. 10.1056\/NEJMoa0801369.","journal-title":"N Engl J Med"},{"issue":"9080","key":"956_CR3","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0140-6736(97)05381-6","volume":"350","author":"JA Staessen","year":"1997","unstructured":"Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhager WH, Bulpitt CJ, de Leeuw PW, Dollery CT, Fletcher AE, et al: Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet. 1997, 350 (9080): 757-764. 10.1016\/S0140-6736(97)05381-6.","journal-title":"Lancet"},{"key":"956_CR4","doi-asserted-by":"crossref","unstructured":"Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA. 1991, 265 (24): 3255-3264.","DOI":"10.1001\/jama.1991.03460240051027"},{"issue":"5","key":"956_CR5","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1097\/00004872-200305000-00011","volume":"21","author":"H Lithell","year":"2003","unstructured":"Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B, Trenkwalder P, Zanchetti A, Group SS: The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens. 2003, 21 (5): 875-886. 10.1097\/00004872-200305000-00011.","journal-title":"J Hypertens"},{"key":"956_CR6","volume-title":"Cochrane Database Syst Rev","author":"VM Musini","year":"2009","unstructured":"Musini VM, Tejani AM, Bassett K, Wright JM: Pharmacotherapy for hypertension in the elderly. Cochrane Database Syst Rev. 2009, 4: CD000028"},{"issue":"2","key":"956_CR7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1001\/archinte.1993.00410020010002","volume":"153","author":"The fifth report of the Joint National Committee on Detection","year":"1993","unstructured":"The fifth report of the Joint National Committee on Detection: Evaluation, and treatment of high blood pressure (JNC V). Arch Intern Med. 1993, 153 (2): 154-183.","journal-title":"Arch Intern Med"},{"issue":"19","key":"956_CR8","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","volume":"289","author":"AV Chobanian","year":"2003","unstructured":"Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, et al: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003, 289 (19): 2560-2572. 10.1001\/jama.289.19.2560.","journal-title":"JAMA"},{"issue":"4","key":"956_CR9","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.arr.2013.06.004","volume":"12","author":"DA Robertson","year":"2013","unstructured":"Robertson DA, Savva GM, Kenny RA: Frailty and cognitive impairment-A review of the evidence and causal mechanisms. Ageing Res Rev. 2013, 12 (4): 840-851. 10.1016\/j.arr.2013.06.004.","journal-title":"Ageing Res Rev"},{"issue":"4","key":"956_CR10","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1159\/000247586","volume":"28","author":"H Sonnesyn","year":"2009","unstructured":"Sonnesyn H, Nilsen DW, Rongve A, Nore S, Ballard C, Tysnes OB, Aarsland D: High prevalence of orthostatic hypotension in mild dementia. Dement Geriatr Cogn Disord. 2009, 28 (4): 307-313. 10.1159\/000247586.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"3","key":"956_CR11","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1159\/000236913","volume":"28","author":"C Qiu","year":"2009","unstructured":"Qiu C, Winblad B, Fratiglioni L: Low diastolic pressure and risk of dementia in very old people: a longitudinal study. Dement Geriatr Cogn Disord. 2009, 28 (3): 213-219. 10.1159\/000236913.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"9","key":"956_CR12","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.jclinepi.2012.02.018","volume":"65","author":"D Gnjidic","year":"2012","unstructured":"Gnjidic D, Hilmer SN, Blyth FM, Naganathan V, Waite L, Seibel MJ, McLachlan AJ, Cumming RG, Handelsman DJ, Le Couteur DG: Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012, 65 (9): 989-995. 10.1016\/j.jclinepi.2012.02.018.","journal-title":"J Clin Epidemiol"},{"issue":"7","key":"956_CR13","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1111\/jgs.12322_1","volume":"61","author":"JE Morley","year":"2013","unstructured":"Morley JE: Systolic hypertension should Not Be treated in persons aged 80 and older until blood pressure is greater than 160\u00a0mmHg. J Am Geriatr Soc. 2013, 61 (7): 1197-1198. 10.1111\/jgs.12322_1.","journal-title":"J Am Geriatr Soc"},{"key":"956_CR14","volume-title":"Assessing the risk of bias of individual studies in systematic reviews of health care interventions","author":"MAM Viswanathan","year":"2012","unstructured":"Viswanathan MAM, Berkman ND, Chang S, Hartling L, McPheeters LM, Santaguida PL, Shamliyan T, Singh K, Tsertsvadze A, Treadwell JR: Assessing the risk of bias of individual studies in systematic reviews of health care interventions. 2012, USA: DoHaHS: AHRQ"},{"issue":"1","key":"956_CR15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/MJT.0b013e318197eaa3","volume":"17","author":"I Poon","year":"2010","unstructured":"Poon I, Lal LS, Ford ME, Braun UK: Racial\/ethnic differences in blood pressure control and medication utilization in a cohort of older veterans with dementia. Am J Ther. 2010, 17 (1): 34-41. 10.1097\/MJT.0b013e318197eaa3.","journal-title":"Am J Ther"},{"issue":"9","key":"956_CR16","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1111\/j.1532-5415.2000.tb04777.x","volume":"48","author":"SS Richards","year":"2000","unstructured":"Richards SS, Emsley CL, Roberts J, Murray MD, Hall K, Gao S, Hendrie HC: The association between vascular risk factor-mediating medications and cognition and dementia diagnosis in a community-based sample of African-Americans. J Am Geriatr Soc. 2000, 48 (9): 1035-1041.","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"956_CR17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-2011-110347","volume":"26","author":"NM Davies","year":"2011","unstructured":"Davies NM, Kehoe PG, Ben-Shlomo Y, Martin RM: Associations of anti-hypertensive treatments with Alzheimer\u2019s disease, vascular dementia, and other dementias. J Alzheimers Dis. 2011, 26 (4): 699-708.","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"956_CR18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3233\/JAD-121819","volume":"35","author":"P Imfeld","year":"2013","unstructured":"Imfeld P, Brauchli Pernus YB, Jick SS, Meier CR: Epidemiology, co-morbidities, and medication use of patients with Alzheimer\u2019s disease or vascular dementia in the UK. J Alzheimers Dis. 2013, 35 (3): 565-573.","journal-title":"J Alzheimers Dis"},{"issue":"10","key":"956_CR19","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1097\/01.hjh.0000244961.69985.05","volume":"24","author":"O Hanon","year":"2006","unstructured":"Hanon O, Pequignot R, Seux ML, Lenoir H, Bune A, Rigaud AS, Forette F, Girerd X: Relationship between antihypertensive drug therapy and cognitive function in elderly hypertensive patients with memory complaints. J Hypertens. 2006, 24 (10): 2101-2107. 10.1097\/01.hjh.0000244961.69985.05.","journal-title":"J Hypertens"},{"issue":"9","key":"956_CR20","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/ajh.2009.119","volume":"22","author":"E Duron","year":"2009","unstructured":"Duron E, Rigaud AS, Dubail D, Mehrabian S, Latour F, Seux ML, Hanon O: Effects of antihypertensive therapy on cognitive decline in Alzheimer\u2019s disease. Am J Hypertens. 2009, 22 (9): 1020-1024. 10.1038\/ajh.2009.119.","journal-title":"Am J Hypertens"},{"issue":"3-A","key":"956_CR21","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1590\/S0004-282X2002000400006","volume":"60","author":"FA Vale","year":"2002","unstructured":"Vale FA, Miranda SJ: Clinical and demographic features of patients with dementia attended in a tertiary outpatient clinic. Arq Neuropsiquiatr. 2002, 60 (3-A): 548-552.","journal-title":"Arq Neuropsiquiatr"},{"issue":"1","key":"956_CR22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1001\/archneur.1997.00550130019010","volume":"54","author":"K Rockwood","year":"1997","unstructured":"Rockwood K, Ebly E, Hachinski V, Hogan D: Presence and treatment of vascular risk factors in patients with vascular cognitive impairment. Arch Neurol. 1997, 54 (1): 33-39. 10.1001\/archneur.1997.00550130019010.","journal-title":"Arch Neurol"},{"issue":"2","key":"956_CR23","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1159\/000093739","volume":"22","author":"M Lopponen","year":"2006","unstructured":"Lopponen M, Raiha I, Isoaho R, Vahlberg T, Puolijoki H, Kivela SL: Dementia associates with undermedication of cardiovascular diseases in the elderly: a population-based study. Dement Geriatr Cogn Disord. 2006, 22 (2): 132-141. 10.1159\/000093739.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"578","key":"956_CR24","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3399\/bjgp10X515395","volume":"60","author":"J Muther","year":"2010","unstructured":"Muther J, Abholz HH, Wiese B, Fuchs A, Wollny A, Pentzek M: Are patients with dementia treated as well as patients without dementia for hypertension, diabetes, and hyperlipidaemia?. Br J Gen Pract. 2010, 60 (578): 671-674. 10.3399\/bjgp10X515395.","journal-title":"Br J Gen Pract"},{"issue":"5","key":"956_CR25","doi-asserted-by":"publisher","first-page":"377","DOI":"10.4314\/ajpsy.v14i5.5","volume":"14","author":"G Amoo","year":"2011","unstructured":"Amoo G, Akinyemi RO, Onofa LU, Akinyemi JO, Baiyewu O, Ogunlesi AO, Ogunniyi A: Profile of clinically-diagnosed dementias in a neuropsychiatric practice in Abeokuta, south-western Nigeria. Afr J Psychiatry. 2011, 14 (5): 377-382.","journal-title":"Afr J Psychiatry"},{"key":"956_CR26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1471-2318-11-58","volume":"11","author":"F Andersen","year":"2011","unstructured":"Andersen F, Viitanen M, Halvorsen DS, Straume B, Engstad TA: Co-morbidity and drug treatment in Alzheimer\u2019s disease. A cross sectional study of participants in the dementia study in northern Norway. BMC Geriatr. 2011, 11: 58-10.1186\/1471-2318-11-58.","journal-title":"BMC Geriatr"},{"issue":"2","key":"956_CR27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/WAD.0b013e3181fcba68","volume":"25","author":"CW Zhu","year":"2011","unstructured":"Zhu CW, Livote EE, Kahle-Wrobleski K, Scarmeas N, Albert M, Brandt J, Blacker D, Sano M, Stern Y: Utilization of antihypertensives, antidepressants, antipsychotics, and hormones in Alzheimer disease. Alzheimer Dis Assoc Disord. 2011, 25 (2): 144-148. 10.1097\/WAD.0b013e3181fcba68.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"956_CR28","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1146\/annurev.publhealth.27.021405.102132","volume":"27","author":"I Hajjar","year":"2006","unstructured":"Hajjar I, Kotchen JM, Kotchen TA: Hypertension: trends in prevalence, incidence, and control. Annu Rev Public Health. 2006, 27: 465-490. 10.1146\/annurev.publhealth.27.021405.102132.","journal-title":"Annu Rev Public Health"},{"issue":"3","key":"956_CR29","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1161\/01.HYP.23.3.275","volume":"23","author":"National High Blood Pressure Education Program Working Group","year":"1994","unstructured":"National High Blood Pressure Education Program Working Group: National high blood pressure education program working group report on hypertension in the elderly. Hypertension. 1994, 23 (3): 275-285.","journal-title":"Hypertension"},{"key":"956_CR30","doi-asserted-by":"crossref","unstructured":"After the diagnosis: adherence and persistence with hypertension therapy. Am J Manag Care. 2005, 11 (13): S395-S399.","DOI":"10.1016\/j.ymthe.2005.07.579"},{"issue":"4","key":"956_CR31","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0149-2918(98)80130-6","volume":"20","author":"BS Bloom","year":"1998","unstructured":"Bloom BS: Continuation of initial antihypertensive medication after 1\u00a0year of therapy. Clin Ther. 1998, 20 (4): 671-681. 10.1016\/S0149-2918(98)80130-6.","journal-title":"Clin Ther"},{"issue":"8","key":"956_CR32","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1161\/01.STR.0000133128.42462.ef","volume":"35","author":"C Qiu","year":"2004","unstructured":"Qiu C, von Strauss E, Winblad B, Fratiglioni L: Decline in blood pressure over time and risk of dementia: a longitudinal study from the Kungsholmen project. Stroke. 2004, 35 (8): 1810-1815. 10.1161\/01.STR.0000133128.42462.ef.","journal-title":"Stroke"},{"issue":"3","key":"956_CR33","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/clpt.2011.258","volume":"91","author":"D Gnjidic","year":"2012","unstructured":"Gnjidic D, Hilmer SN, Blyth FM, Naganathan V, Cumming RG, Handelsman DJ, McLachlan AJ, Abernethy DR, Banks E, Le Couteur DG: High-risk prescribing and incidence of frailty among older community-dwelling men. Clin Pharmacol Ther. 2012, 91 (3): 521-528. 10.1038\/clpt.2011.258.","journal-title":"Clin Pharmacol Ther"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-14-19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2318-14-19\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-14-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T11:32:07Z","timestamp":1565177527000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/1471-2318-14-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,12]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["956"],"URL":"https:\/\/doi.org\/10.1186\/1471-2318-14-19","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,12]]},"article-number":"19"}}