{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:42:43Z","timestamp":1780670563024,"version":"3.54.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,7,14]],"date-time":"2008-07-14T00:00:00Z","timestamp":1215993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1471-2318-8-14","type":"journal-article","created":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T06:13:45Z","timestamp":1216102425000},"source":"Crossref","is-referenced-by-count":51,"title":["The association of APOE genotype and cognitive decline in interaction with risk factors in a 65\u201369 year old community sample"],"prefix":"10.1186","volume":"8","author":[{"given":"Helen","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Batterham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Mackinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony F","family":"Jorm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A","family":"Mather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaarin J","family":"Anstey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perminder S","family":"Sachdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Easteal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,7,14]]},"reference":[{"issue":"1","key":"108_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/0894-4105.21.1.1","volume":"21","author":"AF Jorm","year":"2007","unstructured":"Jorm AF, Mather KA, Butterworth P, Anstey KJ, Christensen H, Easteal S: APOE genotype and cognitive functioning in a large age-stratified population sample. Neuropsychology. 2007, 21 (1): 1-8. 10.1037\/0894-4105.21.1.1.","journal-title":"Neuropsychology"},{"issue":"3","key":"108_CR2","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.ncl.2007.03.009","volume":"25","author":"N Ertekin-Taner","year":"2007","unstructured":"Ertekin-Taner N: Genetics of Alzheimer's Disease: A centennial review. Neurologic clinics. 2007, 25 (3): 611-67, v. 10.1016\/j.ncl.2007.03.009.","journal-title":"Neurologic clinics"},{"issue":"8873","key":"108_CR3","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/0140-6736(93)91709-U","volume":"342","author":"AM Saunders","year":"1993","unstructured":"Saunders AM, Schmader K, Breitner JC, Benson MD, Brown WT, Goldfarb L, Goldgaber D, Manwaring MG, Szymanski MH, McCown N, Dole KC, Schmechel DE, Strittmatter WJ, Pericak-Vance MA, Roses AD: Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet. 1993, 342 (8873): 710-711. 10.1016\/0140-6736(93)91709-U.","journal-title":"Lancet"},{"issue":"7","key":"108_CR4","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1212\/WNL.58.7.1115","volume":"58","author":"FC Crawford","year":"2002","unstructured":"Crawford FC, Vanderploeg RD, Freeman MJ, Singh S, Waisman M, Michaels L, Abdullah L, Warden D, Lipsky R, Salazar A, Mullan MJ: APOE genotype influences acquisition and recall following traumatic brain injury. Neurology. 2002, 58 (7): 1115-1118.","journal-title":"Neurology"},{"issue":"11","key":"108_CR5","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1001\/jama.289.11.1405","volume":"289","author":"KJ Mukamal","year":"2003","unstructured":"Mukamal KJ, Kuller LH, Fitzpatrick AL, Longstreth WT, Mittleman MA, Siscovick DS: Prospective study of alcohol consumption and risk of dementia in older adults. Journal of the American Medical Association. 2003, 289 (11): 1405-1413. 10.1001\/jama.289.11.1405.","journal-title":"Journal of the American Medical Association"},{"issue":"6","key":"108_CR6","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1159\/000026271","volume":"19","author":"JM Johnston","year":"2000","unstructured":"Johnston JM, Nazar-Stewart V, Kelsey SF, Kamboh MI, Ganguli M: Relationships between cerebrovascular events, APOE polymorphism and Alzheimer's disease in a community sample. Neuroepidemiology. 2000, 19 (6): 320-326. 10.1159\/000026271.","journal-title":"Neuroepidemiology"},{"issue":"5","key":"108_CR7","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1161\/01.STR.0000160747.27470.2a","volume":"36","author":"JA Schneider","year":"2005","unstructured":"Schneider JA, Bienias JL, Wilson RS, Berry-Kravis E, Evans DA, Bennett DA: The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons. Stroke; a journal of cerebral circulation. 2005, 36 (5): 954-959.","journal-title":"Stroke; a journal of cerebral circulation"},{"issue":"2","key":"108_CR8","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1037\/0882-7974.17.2.194","volume":"17","author":"SM Hofer","year":"2002","unstructured":"Hofer SM, Christensen H, Mackinnon AJ, Korten AE, Jorm AF, Henderson AS, Easteal S: Change in cognitive functioning associated with apoE genotype in a community sample of older adults. Psychology and aging. 2002, 17 (2): 194-208. 10.1037\/0882-7974.17.2.194.","journal-title":"Psychology and aging"},{"issue":"1","key":"108_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1037\/0882-7974.13.1.80","volume":"13","author":"BJ Small","year":"1998","unstructured":"Small BJ, Basun H, Backman L: Three-year changes in cognitive performance as a function of apolipoprotein E genotype: evidence from very old adults without dementia. Psychology and aging. 1998, 13 (1): 80-87. 10.1037\/0882-7974.13.1.80.","journal-title":"Psychology and aging"},{"issue":"7","key":"108_CR10","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1001\/archneur.59.7.1154","volume":"59","author":"RS Wilson","year":"2002","unstructured":"Wilson RS, Schneider JA, Barnes LL, Beckett LA, Aggarwal NT, Cochran EJ, Berry-Kravis E, Bach J, Fox JH, Evans DA, Bennett DA: The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period. Archives of Neurology. 2002, 59 (7): 1154-1160. 10.1001\/archneur.59.7.1154.","journal-title":"Archives of Neurology"},{"issue":"21","key":"108_CR11","doi-asserted-by":"publisher","first-page":"11661","DOI":"10.1073\/pnas.97.21.11661","volume":"97","author":"PM Greenwood","year":"2000","unstructured":"Greenwood PM, Sunderland T, Friz JL, Parasuraman R: Genetics and visual attention: selective deficits in healthy adult carriers of the epsilon 4 allele of the apolipoprotein E gene. Proceedings of the National Academy of Sciences of the United States of America. 2000, 97 (21): 11661-11666. 10.1073\/pnas.97.21.11661.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"108_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1037\/0894-4105.19.2.199","volume":"19","author":"PM Greenwood","year":"2005","unstructured":"Greenwood PM, Lambert C, Sunderland T, Parasuraman R: Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults: results from the National Institute of Mental Health's BIOCARD study. Neuropsychology. 2005, 19 (2): 199-211. 10.1037\/0894-4105.19.2.199.","journal-title":"Neuropsychology"},{"issue":"7","key":"108_CR13","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1001\/archneur.63.7.936","volume":"63","author":"ER Peskind","year":"2006","unstructured":"Peskind ER, Li G, Shofer J, Quinn JF, Kaye JA, Clark CM, Farlow MR, DeCarli C, Raskind MA, Schellenberg GD, Lee VM, Galasko DR: Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition. Archives of Neurology. 2006, 63 (7): 936-939. 10.1001\/archneur.63.7.936.","journal-title":"Archives of Neurology"},{"issue":"2","key":"108_CR14","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1037\/0894-4105.21.2.158","volume":"21","author":"M Albert","year":"2007","unstructured":"Albert M, Blacker D, Moss MB, Tanzi R, McArdle JJ: Longitudinal change in cognitive performance among individuals with mild cognitive impairment. Neuropsychology. 2007, 21 (2): 158-169. 10.1037\/0894-4105.21.2.158.","journal-title":"Neuropsychology"},{"issue":"4","key":"108_CR15","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1037\/0894-4105.19.4.520","volume":"19","author":"L Backman","year":"2005","unstructured":"Backman L, Jones S, Berger AK, Laukka EJ, Small BJ: Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis. Neuropsychology. 2005, 19 (4): 520-531. 10.1037\/0894-4105.19.4.520.","journal-title":"Neuropsychology"},{"issue":"2","key":"108_CR16","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1037\/0882-7974.14.2.295","volume":"14","author":"MW Bondi","year":"1999","unstructured":"Bondi MW, Salmon DP, Galasko D, Thomas RG, Thal LJ: Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease. Psychology and aging. 1999, 14 (2): 295-303. 10.1037\/0882-7974.14.2.295.","journal-title":"Psychology and aging"},{"issue":"3","key":"108_CR17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR: \"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician. Journal of psychiatric research. 1975, 12 (3): 189-198. 10.1016\/0022-3956(75)90026-6.","journal-title":"Journal of psychiatric research"},{"issue":"3","key":"108_CR18","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1136\/mp.56.3.132","volume":"56","author":"N Nathoo","year":"2003","unstructured":"Nathoo N, Chetty R, van Dellen JR, Barnett GH: Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E. Molecular Pathology. 2003, 56 (3): 132-136. 10.1136\/mp.56.3.132.","journal-title":"Molecular Pathology"},{"issue":"4","key":"108_CR19","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S0197-4580(01)00223-8","volume":"22","author":"R Mayeux","year":"2001","unstructured":"Mayeux R, Small SA, Tang M, Tycko B, Stern Y: Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiology of aging. 2001, 22 (4): 683-689. 10.1016\/S0197-4580(01)00223-8.","journal-title":"Neurobiology of aging"},{"key":"108_CR20","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.intell.2003.08.001","volume":"32","author":"AF Jorm","year":"2004","unstructured":"Jorm AF, Anstey KJ, Christensen H, Rodgers B: Gender differences in cognitive abilities: The mediating role of health state and health habits. Intelligence. 2004, 32: 545-548. 10.1016\/j.intell.2003.08.001.","journal-title":"Intelligence"},{"issue":"3","key":"108_CR21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)43176-1","volume":"31","author":"JE Hixson","year":"1990","unstructured":"Hixson JE, Vernier DT: Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. Journal of lipid research. 1990, 31 (3): 545-548.","journal-title":"Journal of lipid research"},{"issue":"7","key":"108_CR22","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.jclinepi.2003.10.015","volume":"57","author":"P Butterworth","year":"2004","unstructured":"Butterworth P, Anstey K, Jorm AF, Rodgers B: A community survey demonstrated cohort differences in the lifetime prevalence of self-reported head injury. Journal of clinical epidemiology. 2004, 57 (7): 742-748. 10.1016\/j.jclinepi.2003.10.015.","journal-title":"Journal of clinical epidemiology"},{"issue":"6","key":"108_CR23","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1360-0443.1993.tb02093.x","volume":"88","author":"JB Saunders","year":"1993","unstructured":"Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M: Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. Addiction (Abingdon, England). 1993, 88 (6): 791-804.","journal-title":"Addiction (Abingdon, England)"},{"key":"108_CR24","volume-title":"The Spot-the-Word Test","author":"A Baddeley","year":"1992","unstructured":"Baddeley A, Emslie H, Nimmo-Smith I: The Spot-the-Word Test. 1992, Bury St. Edmunds, United Kingdom , Thames Valley Test Company"},{"key":"108_CR25","volume-title":"Symbol\u2013Digit Modalities Test (SDMT) manual","author":"A Smith","year":"1982","unstructured":"Smith A: Symbol\u2013Digit Modalities Test (SDMT) manual. 1982, Los Angeles, CA , Western Psychological Services"},{"issue":"1","key":"108_CR26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/02724980443000232","volume":"58","author":"KJ Anstey","year":"2005","unstructured":"Anstey KJ, Dear K, Christensen H, Jorm AF: Biomarkers, health, lifestyle, and demographic variables as correlates of reaction time performance in early, middle, and late adulthood. The Quarterly journal of experimental psychology. 2005, 58 (1): 5-21.","journal-title":"The Quarterly journal of experimental psychology"},{"key":"108_CR27","volume-title":"California Verbal Learning Test","author":"DC Delis","year":"1987","unstructured":"Delis DC, Kramer JH, Kaplan E, Ober BA: California Verbal Learning Test. 1987, San Antonio, TX , Psychological Corporation \/ Harcourt Brace Jovanovich"},{"key":"108_CR28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/00223980.1945.9917223","volume":"19","author":"D Wechsler","year":"1945","unstructured":"Wechsler D: A standardized memory scale for clinical use. Journal of Psychology. 1945, 19: 87-95.","journal-title":"Journal of Psychology"},{"issue":"2-3","key":"108_CR29","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000082351","volume":"19","author":"R Kumar","year":"2005","unstructured":"Kumar R, Dear KB, Christensen H, Ilschner S, Jorm AF, Meslin C, Rosenman SJ, Sachdev PS: Prevalence of mild cognitive impairment in 60- to 64-year-old community-dwelling individuals: The Personality and Total Health through Life 60+ Study. Dementia and geriatric cognitive disorders. 2005, 19 (2-3): 67-74. 10.1159\/000082351.","journal-title":"Dementia and geriatric cognitive disorders"},{"issue":"3","key":"108_CR30","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1001\/archneur.56.3.303","volume":"56","author":"RC Petersen","year":"1999","unstructured":"Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999, 56 (3): 303-308. 10.1001\/archneur.56.3.303.","journal-title":"Arch Neurol"},{"key":"108_CR31","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/87565648609540348","volume":"2","author":"T Crook","year":"1986","unstructured":"Crook T, Bartus RT, Ferris SH, Whitehouse P, Cohen GD, Gershon S: Age-associated memory impairment. Proposed diagnostic criteria and measures of clinical change. Report of a National Institute of Mental Health work group. Developmental Neuropsychology. 1986, 2: 261-276.","journal-title":"Developmental Neuropsychology"},{"issue":"1","key":"108_CR32","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1017\/S1041610294001626","volume":"6","author":"R Levy","year":"1994","unstructured":"Levy R: Aging-associated cognitive decline. Working Party of the International Psychogeriatric Association in collaboration with the World Health Organization. Int Psychogeriatr. 1994, 6 (1): 63-68. 10.1017\/S1041610294001626.","journal-title":"Int Psychogeriatr"},{"key":"108_CR33","volume-title":"Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV).","author":"American Psychiatric Association","year":"1994","unstructured":"American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). 1994, Washington, DC , American Psychiatric Press, Inc."},{"issue":"7","key":"108_CR34","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/S0149-7634(02)00070-2","volume":"26","author":"LG Nilsson","year":"2002","unstructured":"Nilsson LG, Nyberg L, Backman L: Genetic variation in memory functioning. Neuroscience & Biobehavioral Reviews. 2002, 26 (7): 841-848. 10.1016\/S0149-7634(02)00070-2.","journal-title":"Neuroscience & Biobehavioral Reviews"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2318-8-14\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-8-14.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-8-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2318-8-14.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T04:07:16Z","timestamp":1631506036000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/1471-2318-8-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,14]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["108"],"URL":"https:\/\/doi.org\/10.1186\/1471-2318-8-14","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,14]]},"article-number":"14"}}