{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:23:10Z","timestamp":1774664590690,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T00:00:00Z","timestamp":1340323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Hematol"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1471-2326-12-6","type":"journal-article","created":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T14:48:53Z","timestamp":1352818133000},"source":"Crossref","is-referenced-by-count":47,"title":["Health related quality of life in Middle Eastern children with beta-thalassemia"],"prefix":"10.1186","volume":"12","author":[{"given":"Giovanni","family":"Caocci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Efficace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ciotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Roncarolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Vacca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Piras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Littera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raji Suleiman Dawood","family":"Markous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary Stephen","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Mandelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Marktel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"La Nasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,6,22]]},"reference":[{"key":"58_CR1","first-page":"1187","volume":"89","author":"C Borgna-Pignatti","year":"2004","unstructured":"Borgna-Pignatti C, Rugolotto S, De Stefano P, Zhao H, Cappellini MD, Del Vecchio GC, Romeo MA, Forni GL, Gamberini MR, Ghilardi R, Piga A, Cnaan A: Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004, 89: 1187-1193.","journal-title":"Haematologica"},{"key":"58_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1080\/08880010601001461","volume":"24","author":"C Borgna-Pignatti","year":"2007","unstructured":"Borgna-Pignatti C: Surviving with thalassemia major: the Italian experience. Pediatr Hematol Oncol. 2007, 24: 75-78. 10.1080\/08880010601001461.","journal-title":"Pediatr Hematol Oncol"},{"key":"58_CR3","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1056\/NEJMra050436","volume":"353","author":"D Rund","year":"2005","unstructured":"Rund D, Rachmilewitz E: \u03b2-Thalassemia. New Engl J Med. 2005, 353: 1135-1146. 10.1056\/NEJMra050436.","journal-title":"New Engl J Med"},{"key":"58_CR4","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0277-9536(00)00364-6","volume":"53","author":"K Atkin","year":"2001","unstructured":"Atkin K, Ahmad W: Living a \u201cnormal life\u201d: young people coping with thalassemia major or sickel cell disorder. Soc Sci Med. 2001, 53: 615-626. 10.1016\/S0277-9536(00)00364-6.","journal-title":"Soc Sci Med"},{"key":"58_CR5","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1002\/sim.4780101207","volume":"10","author":"M Schumacher","year":"1991","unstructured":"Schumacher M, Olschewski M, Schulgen G: Assessment of quality of life in clinical trials. Stat Med. 1991, 10: 1915-1930. 10.1002\/sim.4780101207.","journal-title":"Stat Med"},{"key":"58_CR6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1001\/jama.1997.03550010061041","volume":"278","author":"A Leplege","year":"1997","unstructured":"Leplege A, Hunt S: The problem of quality of life in medicine. JAMA. 1997, 278: 47-50. 10.1001\/jama.1997.03550010061041.","journal-title":"JAMA"},{"key":"58_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1196\/annals.1345.035","volume":"1054","author":"P Tefler","year":"2005","unstructured":"Tefler P, Constantinidou G, Andreou P, Christou S, Modell B, Angastiniotis M: Quality of Life in Thalassaemia. Ann N Y Acad Sci. 2005, 1054: 273-282. 10.1196\/annals.1345.035.","journal-title":"Ann N Y Acad Sci"},{"key":"58_CR8","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1196\/annals.1345.059","volume":"1054","author":"Z Pakbaz","year":"2005","unstructured":"Pakbaz Z, Treadwell M, Yamashita R, Quirolo K, Foote D, Quill L, Singer T, Vichinsky EP: Quality of Life in Patients with Thalassaemia Intermedia Compared to Thalassaemia Major. Ann N Y Acad Sci. 2005, 1054: 457-461. 10.1196\/annals.1345.059.","journal-title":"Ann N Y Acad Sci"},{"key":"58_CR9","first-page":"794","volume":"50","author":"M Dahlui","year":"2009","unstructured":"Dahlui M, Hishamshah MI, Rahman AJ, Aljunid SM: Quality of life in transfusion-dependent thalassaemia patients on desferrioxamine treatment. Singapore Med J. 2009, 50: 794-799.","journal-title":"Singapore Med J"},{"key":"58_CR10","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1185\/03007990802160834","volume":"24","author":"L Scalone","year":"2008","unstructured":"Scalone L, Mantovani LG, Krol M, Rofail D, Ravera S, Bisconte MG, Borgna-Pignatti C, Borsellino Z, Cianciulli P, Gallisai D, Prossomariti L, Stef\u00e0no I, Cappellini MD: Costs, quality of life, treatment satisfaction and compliance in patients with beta-thalassemia major undergoing iron chelation therapy: the ITHACA study. Curr Med Res Opin. 2008, 24: 1905-1917. 10.1185\/03007990802160834.","journal-title":"Curr Med Res Opin"},{"key":"58_CR11","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1002\/cncr.10428","volume":"94","author":"JW Varni","year":"2002","unstructured":"Varni JW, Burwinkle TM, Katz ER, Meeske K, Dickinson P: The PedsQL in pediatric cancer: Reliability and validity of the pediatric quality of life inventory generic core scales, mutidimensional fatigue scale, and cancer module. Cancer. 2002, 94: 2090-2106. 10.1002\/cncr.10428.","journal-title":"Cancer"},{"key":"58_CR12","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s11136-005-1388-z","volume":"15","author":"JW Varni","year":"2006","unstructured":"Varni JW, Burwinkle TM, Seid M: The PedsQL 4.0 as a school population measure: Feasibility, reliability, and validity. Qual Life Res. 2006, 15: 203-215. 10.1007\/s11136-005-1388-z.","journal-title":"Qual Life Res"},{"key":"58_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1477-7525-4-39","volume":"4","author":"A Ismail","year":"2006","unstructured":"Ismail A, Campbell MJ, Ibrahim HM, Jones GL: Health related quality of life in Malaysian children with thalassaemia. Health Qual Life Outcomes. 2006, 4: 39-10.1186\/1477-7525-4-39.","journal-title":"Health Qual Life Outcomes"},{"key":"58_CR14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/bmt.2008.165","volume":"42","author":"DK Cheuk","year":"2008","unstructured":"Cheuk DK, Mok AS, Lee AC, Chiang AK, Ha SY, Lau YL, Chan GC: Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT. Bone Marrow Transplant. 2008, 42: 319-327. 10.1038\/bmt.2008.165.","journal-title":"Bone Marrow Transplant"},{"key":"58_CR15","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/j.1365-2214.2009.01043.x","volume":"36","author":"SA Clarke","year":"2010","unstructured":"Clarke SA, Skinner R, Guest J, Darbyshire P, Cooper J, Shah F, Roberts I, Eiser C: Health-related quality of life and financial impact of caring for a child with Thalassaemia Major in the UK. Child Care Health Dev. 2010, 36: 118-122. 10.1111\/j.1365-2214.2009.01043.x.","journal-title":"Child Care Health Dev"},{"key":"58_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2326-10-1","volume":"10","author":"M Thavorncharoensap","year":"2010","unstructured":"Thavorncharoensap M, Torcharus K, Nuchprayoon I, Riewpaiboon A, Indaratna K, Ubol BO: Factors affecting health-related quality of life in Thai children with thalassemia. BMC Blood Disord. 2010, 10: 1-10.1186\/1471-2326-10-1.","journal-title":"BMC Blood Disord"},{"issue":"Suppl 7","key":"58_CR17","first-page":"65","volume":"93","author":"P Surapolchai","year":"2010","unstructured":"Surapolchai P, Satayasai W, Sinlapamongkolkul P, Udomsubpayakul U: Biopsychosocial predictors of health-related quality of life in children with thalassemia in Thammasat University Hospital. J Med Assoc Thai. 2010, 93 (Suppl 7): 65-75.","journal-title":"J Med Assoc Thai"},{"key":"58_CR18","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1365-2214.2011.01224.x","volume":"38","author":"HF Gharaibeh","year":"2012","unstructured":"Gharaibeh HF, Gharaibeh MK: Factors influencing health-related quality of life of thalassaemic Jordanian children. Child Care Health Dev. 2012, 38: 211-218. 10.1111\/j.1365-2214.2011.01224.x.","journal-title":"Child Care Health Dev"},{"key":"58_CR19","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1200\/JCO.2005.03.9628","volume":"24","author":"KN Speechley","year":"2006","unstructured":"Speechley KN, Barrera M, Shaw AK, Morrison HI, Maunsell E: Health-related quality of life among child and adolescent survivors of childhood cancer. J Clin Oncol. 2006, 24: 2536-2543. 10.1200\/JCO.2005.03.9628.","journal-title":"J Clin Oncol"},{"key":"58_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1477-7525-4-58","volume":"4","author":"J Cremeens","year":"2006","unstructured":"Cremeens J, Eiser C, Blades M: Factors influencing agreement between child self-report and parent proxy-reports on the Pediatric Quality of Life Inventory 4.0 (PedsQL) generic core scales. Health Qual Life Outcomes. 2006, 4: 58-10.1186\/1477-7525-4-58.","journal-title":"Health Qual Life Outcomes"},{"key":"58_CR21","unstructured":"Varni JW: The PedsQL\u2122 Measurement Model for the Pediatric Quality of Life Inventory. \n                    http:\/\/www.pedsql.org\/about_pedsql.html\n                    \n                  last accessed on 22nd May 2012."},{"key":"58_CR22","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1214\/ss\/1009212519","volume":"14","author":"JA Hoeting","year":"1999","unstructured":"Hoeting JA, Madigan D, Raftery AE, Volinsky CT: Bayesian Model Averaging: A Tutorial. Statist Sci. 1999, 14: 382-417. 10.1214\/ss\/1009212519.","journal-title":"Statist Sci"},{"key":"58_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1745-0179-5-5","volume":"5","author":"L Mazzone","year":"2009","unstructured":"Mazzone L, Battaglia L, Andreozzi F, Romeo MA, Mazzone D: Emotional impact in beta-thalassaemia major children following cognitive-behavioural family therapy and quality of life of caregiving mothers. Clin Pract Epidemiol Ment Health. 2009, 5: 5-10.1186\/1745-0179-5-5.","journal-title":"Clin Pract Epidemiol Ment Health"}],"container-title":["BMC Blood Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2326-12-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2326-12-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2326-12-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2326-12-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T09:46:10Z","timestamp":1548236770000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmchematol.biomedcentral.com\/articles\/10.1186\/1471-2326-12-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,22]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["58"],"URL":"https:\/\/doi.org\/10.1186\/1471-2326-12-6","relation":{},"ISSN":["1471-2326"],"issn-type":[{"value":"1471-2326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,22]]},"article-number":"6"}}