{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:50:55Z","timestamp":1791237055160,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T00:00:00Z","timestamp":1275523200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>To control multidrug resistant tuberculosis (MDR-TB), the drug susceptibility profile is needed to guide therapy. Classical drug susceptibility testing (DST) may take up to 2 to 4 months. The GenoType<jats:sup>\u00ae<\/jats:sup> MTBDR<jats:italic>plus<\/jats:italic> test is a commercially available line-probe assay that rapidly detects <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (MTB) complex, as well as the most common mutations associated with rifampin and isoniazid resistance.<\/jats:p>\n            <jats:p>We assessed sensitivity and specificity of the assay by using a geographically representative set of MTB isolates from the South of Vietnam.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We re-cultured 111 MTB isolates that were MDR, rifampin-resistant or pan-susceptible according to conventional DST and tested these with the GenoType<jats:sup>\u00ae<\/jats:sup> MTBDR<jats:italic>plus<\/jats:italic> test.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>By conventional DST, 55 strains were classified as MDR-TB, four strains were rifampicin mono-resistant and 52 strains were susceptible to all first-line drugs. The sensitivity of the GenoType<jats:sup>\u00ae<\/jats:sup> MTBDR<jats:italic>plus<\/jats:italic> was 93.1% for rifampicin, 92.6% for isoniazid and 88.9% for the combination of both; its specificity was 100%. The positive predictive value of the GenoType<jats:sup>\u00ae<\/jats:sup> MTBDR<jats:italic>plus<\/jats:italic> test for MDR-TB was 100% and the negative predictive value 90.3%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>We found a high specificity and positive predictive value of the GenoType<jats:sup>\u00ae<\/jats:sup> MTBDR<jats:italic>plus<\/jats:italic> test for MDR-TB which merits its use in the MDR-TB treatment program in Vietnam.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-10-149","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T18:15:24Z","timestamp":1275588924000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Validation of the GenoType\u00aeMTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam"],"prefix":"10.1186","volume":"10","author":[{"given":"Mai NT","family":"Huyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edine W","family":"Tiemersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen TN","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank GJ","family":"Cobelens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen H","family":"Dung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinh N","family":"Sy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran N","family":"Buu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham T","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxine","family":"Caws","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"van Soolingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,3]]},"reference":[{"key":"1129_CR1","volume-title":"Global tuberculosis control: surveillance, planning, financing. 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