{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:40:03Z","timestamp":1791823203588,"version":"4.3.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T00:00:00Z","timestamp":1278547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Environmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against\n                      <jats:italic>Clostridium difficile<\/jats:italic>\n                      spores, but also safe, rapid, and automated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The Tru-D\u2122 Rapid Room Disinfection device is a mobile, fully-automated room decontamination technology that utilizes ultraviolet-C irradiation to kill pathogens. We examined the efficacy of environmental disinfection using the Tru-D device in the laboratory and in rooms of hospitalized patients. Cultures for\n                      <jats:italic>C. difficile<\/jats:italic>\n                      , methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MRSA), and vancomycin-resistant\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      (VRE) were collected from commonly touched surfaces before and after use of Tru-D.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On inoculated surfaces, application of Tru-D at a reflected dose of 22,000 \u03bcWs\/cm\n                      <jats:sup>2<\/jats:sup>\n                      for ~45 minutes consistently reduced recovery of\n                      <jats:italic>C. difficile<\/jats:italic>\n                      spores and MRSA by &gt;2-3 log\n                      <jats:sub>10<\/jats:sub>\n                      colony forming units (CFU)\/cm\n                      <jats:sup>2<\/jats:sup>\n                      and of VRE by &gt;3-4 log\n                      <jats:sub>10<\/jats:sub>\n                      CFU\/cm\n                      <jats:sup>2<\/jats:sup>\n                      . Similar killing of MRSA and VRE was achieved in ~20 minutes at a reflected dose of 12,000 \u03bcWs\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , but killing of\n                      <jats:italic>C. difficile<\/jats:italic>\n                      spores was reduced. Disinfection of hospital rooms with Tru-D reduced the frequency of positive MRSA and VRE cultures by 93% and of\n                      <jats:italic>C. difficile<\/jats:italic>\n                      cultures by 80%. After routine hospital cleaning of the rooms of MRSA carriers, 18% of sites under the edges of bedside tables (i.e., a frequently touched site not easily amenable to manual application of disinfectant) were contaminated with MRSA, versus 0% after Tru-D (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). The system required &lt;5 minutes to set up and did not require continuous monitoring.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The Tru-D Rapid Room Disinfection device is a novel, automated, and efficient environmental disinfection technology that significantly reduces\n                      <jats:italic>C. difficile<\/jats:italic>\n                      , VRE and MRSA contamination on commonly touched hospital surfaces.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2334-10-197","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T14:14:39Z","timestamp":1278598479000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":202,"title":["Evaluation of an automated ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms"],"prefix":"10.1186","volume":"10","author":[{"given":"Michelle M","family":"Nerandzic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Cadnum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Pultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis J","family":"Donskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,8]]},"reference":[{"key":"1177_CR1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1086\/588566","volume":"29","author":"ER Goodman","year":"2008","unstructured":"Goodman ER, Platt R, Bass R, Onderdonk AB, Yokoe DS, Huang SS: Impact of an environmental cleaning intervention on the presence of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci on surfaces in intensive care unit rooms. Infect Control Hosp Epidemiol. 2008, 29: 593-599. 10.1086\/588566.","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"Suppl","key":"1177_CR2","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1086\/503164","volume":"23","author":"JM Boyce","year":"2002","unstructured":"Boyce JM, Pittet D: Guideline for hand hygiene in health-care settings: Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC\/SHEA\/APIC\/IDSA Hand Hygiene Task Force. Infect Control Hosp Epidemiol. 2002, 23 (Suppl): S3-S40. 10.1086\/503164.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"1177_CR3","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1086\/502369","volume":"25","author":"A Bhalla","year":"2004","unstructured":"Bhalla A, Pultz NJ, Gries DM, Ray AJ, Eckstein EC, Aron DC, Donskey CJ: Acquisition of nosocomial pathogens on hands after contact with environmental surfaces near hospitalized patients. 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