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ESBL-producing <jats:italic>Enterobacteriaceae<\/jats:italic> (ESBL-PE) have been increasingly isolated from nosocomial infections in Antananarivo, Madagascar.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>we conducted a prevalence survey in a pediatric unit from March to April 2008 Patient rectal swabs were sampled on the first and the last day of hospitalization. Medical staff and environment were also sampled. Rectal and environmental swabs were immediately plated onto Drigalski agar supplemented with 3 mg\/liter of ceftriaxon.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Fecal carriage was detected in 21.2% of 244 infants on admission and 57.1% of 154 on discharge, after more than 48 hours of hospitalization (p &lt; 0.001). The species most frequently detected on admission were <jats:italic>Escherichia coli and Klebsiella pneumoniae<\/jats:italic> (36.9%), whereas, on discharge, <jats:italic>K. pneumoniae<\/jats:italic> was the species most frequently detected (52.7%). ESBL-associated resistances were related to trimethoprim-sulfamethoxazole (91.3%), gentamicin (76.1%), ciprofloxacin (50.0%), but not to amikacin and imipenem. The increased prevalence of carriage during hospitalization was related to standard antimicrobial therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The significant emergence of multidrug-resistant enteric pathogens in Malagasy hospitals poses a serious health threat requiring the implementation of surveillance and control measures for nosocomial infections.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-10-204","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T06:15:56Z","timestamp":1279001756000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["High prevalence of fecal carriage of extended-spectrum \u03b2-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar"],"prefix":"10.1186","volume":"10","author":[{"given":"Todisoa","family":"Andriatahina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Randrianirina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliosa Ratsima","family":"Hariniana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Talarmin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honor\u00e9","family":"Raobijaona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Buisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,12]]},"reference":[{"key":"1184_CR1","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1128\/CMR.14.4.933-951.2001","volume":"14","author":"PA Bradford","year":"2001","unstructured":"Bradford PA: Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. 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