{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:50:35Z","timestamp":1791341435599,"version":"4.3.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T00:00:00Z","timestamp":1287964800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      is the major cause of community-acquired pyogenic infections in Taiwan. This retrospective study evaluated the clinical and microbiological characteristics of bacteremic community-acquired pneumonia due to\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      in Taiwanese adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The clinical characteristics of bacteremic community-acquired pneumonia (CAP) in adults due to\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      were compared to those of adults with bacteremic CAP due to\n                      <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      at a tertiary medical center in Taiwan from 2001-2008. Risk factors for mortality of bacteremic CAP due to\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      were analyzed. All clinical isolates of\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      were examined for capsular serotypes, hypermucoviscosity phenotype, aerobactin and\n                      <jats:italic>rmpA<\/jats:italic>\n                      gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      was the dominant cause of bacteremic CAP and was associated with a more fulminant course and a worse prognosis than bacteremic CAP due to\n                      <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      . Initial presentation with septic shock and respiratory failure were independent risk factors for both early and total mortality. Serotype K1 and K2 comprised around half of all isolates. There were no significant differences in the clinical characteristics of patients with bacteremic CAP due to K1\/K2 and non-K1\/K2 isolates. Hypermucoviscosity phenotype as well as the aerobactin and\n                      <jats:italic>rmpA<\/jats:italic>\n                      genes were highly prevalent in the\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      continued to be the dominant cause of bacteremic CAP in Taiwanese adults during 2001-2008. Initial presentation with septic shock and respiratory failure were independent risk factors for both early and total mortality from\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      bacteremic CAP. Serotypes K1\/K2 comprised around half of all isolates, but did not predispose patients to a poor clinical outcome. Physicians should be aware of the poor prognosis of any patient with bacteremic\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      CAP and monitor these patients more closely.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2334-10-307","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T02:15:10Z","timestamp":1288059310000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Bacteremic community-acquired pneumonia due to Klebsiella pneumoniae: Clinical and microbiological characteristics in Taiwan, 2001-2008"],"prefix":"10.1186","volume":"10","author":[{"given":"Yi-Tsung","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yu","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te-Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Phone","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,25]]},"reference":[{"key":"1287_CR1","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s15010-008-7272-3","volume":"36","author":"CM Chang","year":"2008","unstructured":"Chang CM, Lee HC, Lee NY, Lee IW, Wu CJ, Chen PL, Lee CC, Ko NY, Ko WC: Community-acquired Klebsiella pneumoniae complicated skin and soft-tissue infections of extremities: emphasis on cirrhotic patients and gas formation. 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