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A comprehensive meta-analysis was made to provide a more precise estimate of the relationship between them.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Multiple search strategies were used. A fixed effect model was taken<jats:italic>took<\/jats:italic> to estimate pooled OR with 95% confidence interval (CI) for the association between the TNF -238G\/A polymorphism and tuberculosis susceptibility. The Chi-squared-based Q-test and I-squared<jats:italic>I<\/jats:italic>\n              <jats:sup>\n                <jats:italic>2<\/jats:italic>\n              <\/jats:sup> statistic were calculated to examine heterogeneity. Begg\u2019s funnel plot and Egger\u2019s test were used to assess publication bias.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>9 case-control studies were included in this meta-analysis. No significant heterogeneity was demonstrated, and no obvious publication bias was detected among the included studies. The meta-analysis indicated that there was no significant association between the TNF -238G\/A polymorphism and tuberculosis susceptibility (GA+AA versus GG model: OR=1.005, 95% CI: 0.765-1.319; A versus G model: OR=1.000, 95% CI: 0.769-1.300). In the subgroup analyses by ethnicity, types of TB and human immunodeficiency virus (HIV) status, no significant association were identified.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The meta-analysis involving 2723 subjects did not detect any association between the TNF -238G\/A polymorphism and tuberculosis susceptibility.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-12-328","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T17:14:22Z","timestamp":1354122862000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association between tumor necrosis factor alpha-238G\/a polymorphism and tuberculosis susceptibility: a meta-analysis study"],"prefix":"10.1186","volume":"12","author":[{"given":"Zhijiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudi","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"2082_CR1","first-page":"9","volume-title":"The burden of disease caused by TB Global tuberculosis control","author":"World Health Organization","year":"2011","unstructured":"World Health Organization: The burden of disease caused by TB Global tuberculosis control. 2011, 9-27."},{"key":"2082_CR2","unstructured":"World Health Organization: Tuberculosis. 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