{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:16:23Z","timestamp":1773155783518,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The incidence of fungal healthcare-associated infection (HAI) has increased in a major teaching hospital in the northern part of Taiwan over the past decade, especially in the intensive care units (ICUs). The purpose of this study was to determine the factors that were responsible for the outbreak and trend in the ICU.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Surveillance fungal cultures were obtained from \u201csterile\u201d objects, antiseptic solutions, environment of infected patients and hands of medical personnel. Risk factors for comparison included age, gender, admission service, and total length of stay in the ICU, Acute Physiology and Chronic Health Evaluation (APACHE) II scores at admission to the ICU, main diagnosis on ICU admission, use of invasive devices, receipt of hemodialysis, total parenteral nutrition (TPN) use, history of antibiotic therapy before HAI or during ICU stay in no HAI group, and ICU discharge status (ie, dead or alive). Univariable analysis followed by multiple logistic regression analysis was performed to identify the independent risk factors for ICU fungal HAIs and ICU mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>There was a significant trend in ICU fungal HAIs from 1998 to 2009 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). A total of 516 episodes of ICU fungal HAIs were identified; the rates of various infections were urinary tract infection (UTI) (54.8%), blood stream infection (BSI) (30.6%), surgical site infection (SSI) (6.6%), pneumonia (4.5%), other sites (3.5%). The fungi identified were: yeasts (54.8%), <jats:italic>Candida albicans<\/jats:italic> (27.3%), <jats:italic>Candida tropicalis<\/jats:italic> (6.6%), <jats:italic>Candida glabrata<\/jats:italic> (6.6%), <jats:italic>Candida parapsilosis<\/jats:italic> (1.9%), <jats:italic>Candida<\/jats:italic> species (0.8%), and other fungi (1.9%). <jats:italic>Candida albicans<\/jats:italic> accounted for 63% of all <jats:italic>Candida<\/jats:italic> species. Yeasts were found in the environment of more heavily infected patients. The independent risk factors (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) of developing ICU fungal HAIs from all sites were TPN use, sepsis, surgical patients, mechanical ventilation and an indwelling urinary catheter. The independent risk factors for ICU fungal UTI included TPN use, mechanical ventilation and an indwelling urinary catheter. The independent risk factors for ICU fungal BSI included TPN use, sepsis, and higher APACHE II score. The independent risk factors for ICU fungal pneumonia included TPN use, surgical patients. The independent risk factors for ICU fungal SSI included surgical patients, and TPN use. The odds ratios of TPN use in various infection types ranged from 3.51 to 8.82. The risk of mortality in patients with ICU fungal HAIs was over 2 times that of patients without ICU HAIs in the multiple logistic regression analysis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>There was a secular trend of an increasing number of fungal HAIs in our ICU over the past decade. Patients with ICU fungal HAIs had a significantly higher mortality rate than did patients without ICU HAIs. Total parenteral nutrition was a significant risk factor for all types of ICU fungal HAIs, and its use should be monitored closely.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-13-10","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T16:23:02Z","timestamp":1357748582000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A risk factor analysis of healthcare-associated fungal infections in an intensive care unit: a retrospective cohort study"],"prefix":"10.1186","volume":"13","author":[{"given":"Su-Pen","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Yin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Shui","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Der","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Phone","family":"Fung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,1,9]]},"reference":[{"issue":"16","key":"2180_CR1","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1056\/NEJMoa022139","volume":"348","author":"GS Martin","year":"2003","unstructured":"Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003, 348 (16): 1546-1554.","journal-title":"N Engl J Med"},{"issue":"3","key":"2180_CR2","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1017\/S0950268801005507","volume":"126","author":"TL Lamagni","year":"2001","unstructured":"Lamagni TL, Evans BG, Shigematsu M, Johnson EM: Emerging trends in the epidemiology of invasive mycoses in England and Wales (1990\u20139). Epidemiol Infect. 2001, 126 (3): 397-414.","journal-title":"Epidemiol Infect"},{"issue":"1","key":"2180_CR3","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1128\/JCM.01811-10","volume":"49","author":"MC Arendrup","year":"2011","unstructured":"Arendrup MC, Bruun B, Christensen JJ, Fuursted K, Johansen HK, Kjaeldgaard P, Knudsen JD, Kristensen L, Moller J, Nielsen L, et al: National surveillance of fungemia in Denmark (2004 to 2009). J Clin Microbiol. 2011, 49 (1): 325-334.","journal-title":"J Clin Microbiol"},{"issue":"1","key":"2180_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0732-8893(97)00068-0","volume":"29","author":"JA Karlowsky","year":"1997","unstructured":"Karlowsky JA, Zhanel GG, Klym KA, Hoban DJ, Kabani AM: Candidemia in a Canadian tertiary care hospital from 1976 to 1996. Diagn Microbiol Infect Dis. 1997, 29 (1): 5-9.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"5","key":"2180_CR5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2307\/30141234","volume":"18","author":"YC Chen","year":"1997","unstructured":"Chen YC, Chang SC, Sun CC, Yang LS, Hsieh WC, Luh KT: Secular trends in the epidemiology of nosocomial fungal infections at a teaching hospital in Taiwan, 1981 to 1993. Infect Control Hosp Epidemiol. 1997, 18 (5): 369-375.","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"5","key":"2180_CR6","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1093\/infdis\/167.5.1247","volume":"167","author":"C Beck-Sague","year":"1993","unstructured":"Beck-Sague C, Jarvis WR: Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980\u20131990. National Nosocomial Infections Surveillance System. J Infect Dis. 1993, 167 (5): 1247-1251.","journal-title":"J Infect Dis"},{"issue":"3","key":"2180_CR7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1086\/421946","volume":"39","author":"H Wisplinghoff","year":"2004","unstructured":"Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB: Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004, 39 (3): 309-317.","journal-title":"Clin Infect Dis"},{"issue":"9","key":"2180_CR8","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1128\/JCM.00179-11","volume":"49","author":"MC Arendrup","year":"2011","unstructured":"Arendrup MC, Sulim S, Holm A, Nielsen L, Nielsen SD, Knudsen JD, Drenck NE, Christensen JJ, Johansen HK: Diagnostic issues, clinical characteristics, and outcomes for patients with fungemia. J Clin Microbiol. 2011, 49 (9): 3300-3308.","journal-title":"J Clin Microbiol"},{"key":"2180_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-2334-6-21","volume":"6","author":"M Bassetti","year":"2006","unstructured":"Bassetti M, Righi E, Costa A, Fasce R, Molinari MP, Rosso R, Pallavicini FB, Viscoli C: Epidemiological trends in nosocomial candidemia in intensive care. BMC Infect Dis. 2006, 6: 21-","journal-title":"BMC Infect Dis"},{"issue":"Suppl A","key":"2180_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/jac\/29.suppl_A.19","volume":"29","author":"WR Jarvis","year":"1992","unstructured":"Jarvis WR, Martone WJ: Predominant pathogens in hospital infections. J Antimicrob Chemother. 1992, 29 (Suppl A): 19-24.","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl 2","key":"2180_CR11","doi-asserted-by":"publisher","first-page":"S89","DOI":"10.1093\/clinids\/22.Supplement_2.S89","volume":"22","author":"MA Pfaller","year":"1996","unstructured":"Pfaller MA: Nosocomial candidiasis: emerging species, reservoirs, and modes of transmission. Clin Infect Dis. 1996, 22 (Suppl 2): S89-S94.","journal-title":"Clin Infect Dis"},{"issue":"3B","key":"2180_CR12","doi-asserted-by":"publisher","first-page":"86S","DOI":"10.1016\/0002-9343(91)90349-3","volume":"91","author":"SN Banerjee","year":"1991","unstructured":"Banerjee SN, Emori TG, Culver DH, Gaynes RP, Jarvis WR, Horan T, Edwards JR, Tolson J, Henderson T, Martone WJ: Secular trends in nosocomial primary bloodstream infections in the United States, 1980\u20131989. National Nosocomial Infections Surveillance System. Am J Med. 1991, 91 (3B): 86S-89S.","journal-title":"Am J Med"},{"issue":"4","key":"2180_CR13","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1128\/CMR.6.4.428","volume":"6","author":"TG Emori","year":"1993","unstructured":"Emori TG, Gaynes RP: An overview of nosocomial infections, including the role of the microbiology laboratory. Clin Microbiol Rev. 1993, 6 (4): 428-442.","journal-title":"Clin Microbiol Rev"},{"issue":"3B","key":"2180_CR14","doi-asserted-by":"publisher","first-page":"185S","DOI":"10.1016\/0002-9343(91)90367-7","volume":"91","author":"WR Jarvis","year":"1991","unstructured":"Jarvis WR, Edwards JR, Culver DH, Hughes JM, Horan T, Emori TG, Banerjee S, Tolson J, Henderson T, Gaynes RP, et al: Nosocomial infection rates in adult and pediatric intensive care units in the United States. National Nosocomial Infections Surveillance System. Am J Med. 1991, 91 (3B): 185S-191S.","journal-title":"Am J Med"},{"issue":"8","key":"2180_CR15","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1086\/501795","volume":"21","author":"MJ Richards","year":"2000","unstructured":"Richards MJ, Edwards JR, Culver DH, Gaynes RP: Nosocomial infections in combined medical-surgical intensive care units in the United States. Infect Control Hosp Epidemiol. 2000, 21 (8): 510-515.","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"3","key":"2180_CR16","first-page":"195","volume":"21","author":"CM Lee","year":"2011","unstructured":"Lee CM, Su QX, Chow WH, Wang LS, Wang FD, Wang JT, Leu HS, Chow MY, Chuang YC, Hwang KP, Chen YS, Fang CT, Wu SC, Kuo IT, Chien LR, Yen CC, Tseng SH, Chang SC: Report of Taiwan nosocomial infections surveillance system (TNIS), 2009. Infection Control Journal. 2011, 21 (3): 195-201.","journal-title":"Infection Control Journal"},{"issue":"1","key":"2180_CR17","first-page":"19","volume":"95","author":"CC Hung","year":"1996","unstructured":"Hung CC, Chen YC, Chang SC, Luh KT, Hsieh WC: Nosocomial candidemia in a university hospital in Taiwan. J Formos Med Assoc. 1996, 95 (1): 19-28.","journal-title":"J Formos Med Assoc"},{"issue":"1","key":"2180_CR18","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jhin.2010.12.007","volume":"78","author":"LY Chen","year":"2011","unstructured":"Chen LY, Liao SY, Kuo SC, Chen SJ, Chen YY, Wang FD, Yang SP, Fung CP: Changes in the incidence of candidaemia during 2000\u20132008 in a tertiary medical centre in northern Taiwan. J Hosp Infect. 2011, 78 (1): 50-53.","journal-title":"J Hosp Infect"},{"issue":"3","key":"2180_CR19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/0196-6553(88)90053-3","volume":"16","author":"JS Garner","year":"1988","unstructured":"Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM: CDC definitions for nosocomial infections, 1988. Am J Infect Control. 1988, 16 (3): 128-140.","journal-title":"Am J Infect Control"},{"issue":"10","key":"2180_CR20","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1017\/S0195941700015241","volume":"13","author":"TC Horan","year":"1992","unstructured":"Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG: CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992, 13 (10): 606-608.","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"1","key":"2180_CR21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1086\/592984","volume":"30","author":"YY Chen","year":"2009","unstructured":"Chen YY, Wang FD, Liu CY, Chou P: Incidence rate and variable cost of nosocomial infections in different types of intensive care units. Infect Control Hosp Epidemiol. 2009, 30 (1): 39-46.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"2180_CR22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/1471-2334-12-209","volume":"12","author":"YY Chen","year":"2012","unstructured":"Chen YY, Chen LY, Lin SY, Chou P, Liao SY, Wang FD: Surveillance on secular trends of incidence and mortality for device-associated infection in the intensive care unit setting at a tertiary medical center in Taiwan, 2000\u20132008: A retrospective observational study. BMC Infect Dis. 2012, 12: 209-","journal-title":"BMC Infect Dis"},{"issue":"5","key":"2180_CR23","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","volume":"36","author":"TC Horan","year":"2008","unstructured":"Horan TC, Andrus M, Dudeck MA: CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008, 36 (5): 309-332.","journal-title":"Am J Infect Control"},{"issue":"11\u201312","key":"2180_CR24","first-page":"470","volume":"45","author":"A Nedret Koc","year":"2002","unstructured":"Nedret Koc A, Kocagoz S, Erdem F, Gunduz Z: Outbreak of nosocomial fungemia caused by Candida glabrata. Mycoses. 2002, 45 (11\u201312): 470-475.","journal-title":"Mycoses"},{"issue":"7","key":"2180_CR25","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s100960000307","volume":"19","author":"RM Zancope-Oliveira","year":"2000","unstructured":"Zancope-Oliveira RM, James MJ, Derossi AP, Sampaio JL, Muniz MM, Li RK, Nascimento AS, Peralta JM, Reiss E: Strain characterization of Candida parapsilosis fungemia by molecular typing methods. Eur J Clin Microbiol Infect Dis. 2000, 19 (7): 514-520.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"3","key":"2180_CR26","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1056\/NEJM199507203330303","volume":"333","author":"SN Bennett","year":"1995","unstructured":"Bennett SN, McNeil MM, Bland LA, Arduino MJ, Villarino ME, Perrotta DM, Burwen DR, Welbel SF, Pegues DA, Stroud L, et al: Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med. 1995, 333 (3): 147-154.","journal-title":"N Engl J Med"},{"issue":"2","key":"2180_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/BF02560505","volume":"27","author":"YC Huang","year":"1999","unstructured":"Huang YC, Lin TY, Leu HS, Peng HL, Wu JH, Chang HY: Outbreak of Candida parapsilosis fungemia in neonatal intensive care units: clinical implications and genotyping analysis. Infection. 1999, 27 (2): 97-102.","journal-title":"Infection"},{"issue":"3","key":"2180_CR28","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0732-8893(97)81804-4","volume":"29","author":"DJ Diekema","year":"1997","unstructured":"Diekema DJ, Messer SA, Hollis RJ, Wenzel RP, Pfaller MA: An outbreak of Candida parapsilosis prosthetic valve endocarditis. Diagn Microbiol Infect Dis. 1997, 29 (3): 147-153.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"1","key":"2180_CR29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0195-6701(98)90242-0","volume":"39","author":"YC Huang","year":"1998","unstructured":"Huang YC, Lin TY, Leu HS, Wu JL, Wu JH: Yeast carriage on hands of hospital personnel working in intensive care units. J Hosp Infect. 1998, 39 (1): 47-51.","journal-title":"J Hosp Infect"},{"issue":"3","key":"2180_CR30","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1097\/01.CCM.0000202208.37364.7D","volume":"34","author":"C Leon","year":"2006","unstructured":"Leon C, Ruiz-Santana S, Saavedra P, Almirante B, Nolla-Salas J, Alvarez-Lerma F, Garnacho-Montero J, Leon MA: A bedside scoring system (\u201cCandida score\u201d) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med. 2006, 34 (3): 730-737.","journal-title":"Crit Care Med"},{"issue":"7","key":"2180_CR31","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1097\/CCM.0b013e31816fc4cd","volume":"36","author":"JK Chow","year":"2008","unstructured":"Chow JK, Golan Y, Ruthazer R, Karchmer AW, Carmeli Y, Lichtenberg DA, Chawla V, Young JA, Hadley S: Risk factors for albicans and non-albicans candidemia in the intensive care unit. Crit Care Med. 2008, 36 (7): 1993-1998.","journal-title":"Crit Care Med"},{"issue":"8","key":"2180_CR32","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1086\/529435","volume":"46","author":"JK Chow","year":"2008","unstructured":"Chow JK, Golan Y, Ruthazer R, Karchmer AW, Carmeli Y, Lichtenberg D, Chawla V, Young J, Hadley S: Factors associated with candidemia caused by non-albicans Candida species versus Candida albicans in the intensive care unit. Clin Infect Dis. 2008, 46 (8): 1206-1213.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"2180_CR33","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10096-007-0270-z","volume":"26","author":"L Ostrosky-Zeichner","year":"2007","unstructured":"Ostrosky-Zeichner L, Sable C, Sobel J, Alexander BD, Donowitz G, Kan V, Kauffman CA, Kett D, Larsen RA, Morrison V, et al: Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis. 2007, 26 (4): 271-276.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"6","key":"2180_CR34","doi-asserted-by":"publisher","first-page":"R287","DOI":"10.1186\/cc10574","volume":"15","author":"H Muskett","year":"2011","unstructured":"Muskett H, Shahin J, Eyres G, Harvey S, Rowan K, Harrison D: Risk factors for invasive fungal disease in critically ill, adult patients: a systematic review. Crit Care. 2011, 15 (6): R287-","journal-title":"Crit Care"},{"issue":"1","key":"2180_CR35","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1086\/504810","volume":"43","author":"KW Garey","year":"2006","unstructured":"Garey KW, Rege M, Pai MP, Mingo DE, Suda KJ, Turpin RS, Bearden DT: Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study. Clin Infect Dis. 2006, 43 (1): 25-31.","journal-title":"Clin Infect Dis"},{"issue":"9","key":"2180_CR36","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.1128\/AAC.49.9.3640-3645.2005","volume":"49","author":"M Morrell","year":"2005","unstructured":"Morrell M, Fraser VJ, Kollef MH: Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother. 2005, 49 (9): 3640-3645.","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"2180_CR37","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1086\/596757","volume":"48","author":"PG Pappas","year":"2009","unstructured":"Pappas PG, Kauffman CA, Andes D, Benjamin DK, Calandra TF, Edwards JE, Filler SG, Fisher JF, Kullberg BJ, Ostrosky-Zeichner L, et al: Clinical practice guidelines for the management of candidiasis: 2009 update by the infectious diseases society of America. Clin Infect Dis. 2009, 48 (5): 503-535.","journal-title":"Clin Infect Dis"},{"issue":"6","key":"2180_CR38","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1097\/01.sla.0000256914.16754.80","volume":"245","author":"EE Horvath","year":"2007","unstructured":"Horvath EE, Murray CK, Vaughan GM, Chung KK, Hospenthal DR, Wade CE, Holcomb JB, Wolf SE, Mason AD, Cancio LC: Fungal wound infection (not colonization) is independently associated with mortality in burn patients. Ann Surg. 2007, 245 (6): 978-985.","journal-title":"Ann Surg"},{"issue":"9","key":"2180_CR39","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1086\/378745","volume":"37","author":"O Gudlaugsson","year":"2003","unstructured":"Gudlaugsson O, Gillespie S, Lee K, Vande Berg J, Hu J, Messer S, Herwaldt L, Pfaller M, Diekema D: Attributable mortality of nosocomial candidemia, revisited. Clin Infect Dis. 2003, 37 (9): 1172-1177.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"2180_CR40","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1007\/s00134-007-0865-y","volume":"34","author":"ME Bougnoux","year":"2008","unstructured":"Bougnoux ME, Kac G, Aegerter P, D\u2019Enfert C, Fagon JY: Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome. Intensive Care Med. 2008, 34 (2): 292-299.","journal-title":"Intensive Care Med"},{"issue":"5","key":"2180_CR41","first-page":"414","volume":"41","author":"CC Tsai","year":"2008","unstructured":"Tsai CC, Wang CC, Kuo HY, Chiang DH, Lin ML, Liu CY, Yang SP: Adult candidemia at a medical center in northern Taiwan: a retrospective study. J Microbiol Immunol Infect. 2008, 41 (5): 414-421.","journal-title":"J Microbiol Immunol Infect"},{"issue":"5","key":"2180_CR42","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/MCC.0b013e32833e84d2","volume":"16","author":"MC Arendrup","year":"2010","unstructured":"Arendrup MC: Epidemiology of invasive candidiasis. Curr Opin Crit Care. 2010, 16 (5): 445-452.","journal-title":"Curr Opin Crit Care"},{"issue":"2","key":"2180_CR43","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jinf.2007.10.014","volume":"56","author":"GN Forrest","year":"2008","unstructured":"Forrest GN, Weekes E, Johnson JK: Increasing incidence of Candida parapsilosis candidemia with caspofungin usage. J Infect. 2008, 56 (2): 126-129.","journal-title":"J Infect"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-13-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2334-13-10\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-13-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-13-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T21:38:25Z","timestamp":1630532305000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/1471-2334-13-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,9]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["2180"],"URL":"https:\/\/doi.org\/10.1186\/1471-2334-13-10","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,9]]},"assertion":[{"value":"5 April 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"10"}}