{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:21:26Z","timestamp":1787019686897,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute myopericarditis and exertional rhabdomyolysis, two uncommon but well-described diseases with potentially life-threatening effects, are generally considered as independent clinical entities. However, they may in fact be pathophysiologically related under certain circumstances. This is the first ever report of influenza myopericarditis provoked by exertional rhabdomyolysis to the best of our knowledge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 25-year-old immunocompetent Chinese man presented with bilateral leg pain, dizziness, and shortness of breath on admission soon after completing vigorous training comprising running drills. Exertional rhabdomyolysis was diagnosed with 44 fold high serum creatine phosphokinase. Then he developed chest pain, pericardial effusion, changes of electrocardiography and positive troponin I suggestive of myopericarditis. Influenza A (H3N2) virus infection was confirmed by polymerase chain reaction analysis of nasopharyngeal wash samples. Other possible infective and autoimmune causes were excluded. Patient recovered completely with anti-inflammatory therapy and the supportive care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case suggests that clinicians who treat patients with exertional rhabdomyolysis should be aware of the potential vulnerability to acute myopericarditis, especially in the presence of recent influenza A infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2334-13-283","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T20:15:03Z","timestamp":1371759303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Myopericarditis and exertional rhabdomyolysis following an influenza A (H3N2) infection"],"prefix":"10.1186","volume":"13","author":[{"given":"Guo-Shiang","family":"Tseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Yueh","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Tsai","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Chung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenq-Shyong","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"2495_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijcard.2007.10.053","volume":"127","author":"M Imazio","year":"2008","unstructured":"Imazio M, Trinchero R: Myopericarditis: etiology, management, and prognosis. Int J Cardiol. 2008, 127: 17-26. 10.1016\/j.ijcard.2007.10.053.","journal-title":"Int J Cardiol"},{"key":"2495_CR2","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/1471-2334-12-212","volume":"12","author":"I Gaaloul","year":"2012","unstructured":"Gaaloul I, Riabi S, Harrath R, Evans M, Salem NH, Mlayeh S, et al: Sudden unexpected death related to enterovirus myocarditis: histopathology, immunohistochemistry and molecular pathology diagnosis at post-mortem. BMC Infect Dis. 2012, 12: 212-10.1186\/1471-2334-12-212.","journal-title":"BMC Infect Dis"},{"key":"2495_CR3","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1136\/hrt.2006.104067","volume":"94","author":"M Imazio","year":"2008","unstructured":"Imazio M, Cecchi E, Demichelis B, Chinaglia A, Ierna S, Demarie D, et al: Myopericarditis versus viral or idiopathic acute pericarditis. Heart. 2008, 94: 498-501.","journal-title":"Heart"},{"key":"2495_CR4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.cardfail.2005.11.004","volume":"12","author":"A Matsumori","year":"2006","unstructured":"Matsumori A, Shimada T, Chapman NM, Tracy SM, Mason JW: Myocarditis and heart failure associated with hepatitis C virus infection. J Card Fail. 2006, 12: 293-298. 10.1016\/j.cardfail.2005.11.004.","journal-title":"J Card Fail"},{"key":"2495_CR5","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0046-8177(03)00235-1","volume":"34","author":"S Lamparter","year":"2003","unstructured":"Lamparter S, Schoppet M, Pankuweit S, Maisch B: Acute parvovirus B19 infection associated with myocarditis in an immunocompetent adult. Hum Pathol. 2003, 34: 725-728. 10.1016\/S0046-8177(03)00235-1.","journal-title":"Hum Pathol"},{"key":"2495_CR6","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1161\/CIRCULATIONAHA.105.548156","volume":"112","author":"U Kuhl","year":"2005","unstructured":"Kuhl U, Pauschinger M, Seeberg B, Lassner D, Noutsias M, Poller W, et al: Viral persistence in the myocardium is associated with progressive cardiac dysfunction. Circulation. 2005, 112: 1965-1970. 10.1161\/CIRCULATIONAHA.105.548156.","journal-title":"Circulation"},{"key":"2495_CR7","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/BF00144836","volume":"5","author":"RJ Kiel","year":"1989","unstructured":"Kiel RJ, Smith FE, Chason J, Khatib R, Reyes MP: Coxsackievirus B3 myocarditis in C3H\/HeJ mice: description of an inbred model and the effect of exercise on virulence. Eur J Epidemiol. 1989, 5: 348-350. 10.1007\/BF00144836.","journal-title":"Eur J Epidemiol"},{"key":"2495_CR8","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2459\/01.JCM.0000219325.50622.93","volume":"7","author":"C Chimenti","year":"2006","unstructured":"Chimenti C, Pieroni M, Frustaci A: Myocarditis: when to suspect and how to diagnose it in athletes. J Cardiovasc Med (Hagerstown). 2006, 7: 301-306. 10.2459\/01.JCM.0000219325.50622.93.","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"2495_CR9","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1056\/NEJMoa0906695","volume":"361","author":"S Jain","year":"2009","unstructured":"Jain S, Kamimoto L, Bramley AM, Schmitz AM, Benoit SR, Louie J, et al: Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N Engl J Med. 2009, 361: 1935-1944. 10.1056\/NEJMoa0906695.","journal-title":"N Engl J Med"},{"key":"2495_CR10","first-page":"237","volume":"110","author":"D McGregor","year":"1997","unstructured":"McGregor D, Henderson S: Myocarditis, rhabdomyolysis and myoglobinuric renal failure complicating influenza in a young adult. N Z Med J. 1997, 110: 237-","journal-title":"N Z Med J"},{"key":"2495_CR11","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3201\/eid1603.091818","volume":"16","author":"RL Gutierrez","year":"2010","unstructured":"Gutierrez RL, Ellis MW, Decker CF: Rhabdomyolysis and pandemic (H1N1) 2009 pneumonia in adult. Emerg Infect Dis. 2010, 16: 565-10.3201\/eid1603.091818.","journal-title":"Emerg Infect Dis"},{"key":"2495_CR12","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00431-012-1854-x","volume":"172","author":"T Watanabe","year":"2013","unstructured":"Watanabe T: Renal complications of seasonal and pandemic influenza a virus infections. Eur J Pediatr. 2013, 172: 15-22. 10.1007\/s00431-012-1854-x.","journal-title":"Eur J Pediatr"},{"key":"2495_CR13","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1179\/1465328110Y.0000000005","volume":"31","author":"E Sevketoglu","year":"2011","unstructured":"Sevketoglu E, Kural B, Beskardes AE, Hatipoglu S: Exertional rhabdomyolysis after influenza a (H3N2) infection in a basketball player boy. Ann Trop Paediatr. 2011, 31: 93-96. 10.1179\/1465328110Y.0000000005.","journal-title":"Ann Trop Paediatr"},{"key":"2495_CR14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ijcard.2003.04.053","volume":"96","author":"G Punukollu","year":"2004","unstructured":"Punukollu G, Gowda RM, Khan IA, Mehta NJ, Navarro V, Vasavada BC, et al: Elevated serum cardiac troponin I in rhabdomyolysis. Int J Cardiol. 2004, 96: 35-40. 10.1016\/j.ijcard.2003.04.053.","journal-title":"Int J Cardiol"},{"key":"2495_CR15","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.ijcard.2008.04.044","volume":"130","author":"MA Mamas","year":"2008","unstructured":"Mamas MA, Fraser D, Neyses L: Cardiovascular manifestations associated with influenza virus infection. Int J Cardiol. 2008, 130: 304-309. 10.1016\/j.ijcard.2008.04.044.","journal-title":"Int J Cardiol"},{"key":"2495_CR16","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1038\/modpathol.3800158","volume":"17","author":"F Calabrese","year":"2004","unstructured":"Calabrese F, Carturan E, Chimenti C, Pieroni M, Agostini C, Angelini A, et al: Overexpression of tumor necrosis factor (TNF)alpha and TNFalpha receptor I in human viral myocarditis: clinicopathologic correlations. Mod Pathol. 2004, 17: 1108-1118. 10.1038\/modpathol.3800158.","journal-title":"Mod Pathol"},{"key":"2495_CR17","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1128\/JCM.00418-10","volume":"48","author":"S Puzelli","year":"2010","unstructured":"Puzelli S, Buonaguro FM, Facchini M, Palmieri A, Calzoletti L, De Marco MA, et al: Cardiac tamponade and heart failure due to myopericarditis as a presentation of infection with the pandemic H1N1 2009 influenza a virus. J Clin Microbiol. 2010, 48: 2298-2300. 10.1128\/JCM.00418-10.","journal-title":"J Clin Microbiol"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-13-283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2334-13-283\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-13-283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-13-283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T20:23:26Z","timestamp":1630527806000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/1471-2334-13-283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,21]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["2495"],"URL":"https:\/\/doi.org\/10.1186\/1471-2334-13-283","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,21]]},"assertion":[{"value":"13 February 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"283"}}