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Surveillance for candidemia is necessary to detect trends in species distribution and antifungal resistance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The medical and electronic records of all patients who had candidemia at the authors\u2019 hospital from 2009 to 2011 were reviewed for demographic data and clinical information, including the infecting <jats:italic>Candida<\/jats:italic> species, resistance to antifungals and survival, and the presence of risk factors associated with candidemia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 133 distinct episodes of candidemia were identified over the study period. The annual incidence of candidemia ranged between 0.71 and 0.85 cases\/1000 hospital discharges. The most frequent <jats:italic>Candida<\/jats:italic> species were <jats:italic>C. tropicalis<\/jats:italic> (28.6%), followed by <jats:italic>C. albicans<\/jats:italic> (23.3%) and <jats:italic>C. parapsilosis<\/jats:italic> (19.5%). The rates of susceptibility to antifungal agents were as followed: voriconazole (97.8%), itraconazole (69.5%), fluconazole (46.1%), ketoconazole (38.9%). Out of 131 evaluable patients, 34 (26.0%) died within 30 days from the onset of candidemia. <jats:italic>C. tropicalis<\/jats:italic> candidemia was associated with the highest mortality rate (44.7%). Regarding the crude mortality in the different units, patients in Hemato-Oncology ward had the highest mortality rate (66.7%), followed by patients in cardiovascular wards and ICU (57.1% and 25.6%, respectively). Predictors of 30-day mortality were identified by uni- and multivariate analyses. Complicated abdominal surgery, presence of central venous catheter (CVC), neutropenia, candidemia due to <jats:italic>C. tropicalis<\/jats:italic> and poor treatment with fluconazole were significantly associated with the 30-day mortality. Presence of CVC (odds ratio[OR]\u2009=\u20094.177; 95% confidence interval [CI]\u2009=\u20091.698 to 10.278; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) was the only independent predictor for mortality in the multivariate analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This report provides baseline data for future epidemiological and susceptibility studies and for the mortality rates associated with candidemia in our hospital. The knowledge of the local epidemiological trends in <jats:italic>Candida<\/jats:italic> species isolated in blood cultures is important to guide therapeutic choices.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-13-337","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T08:16:59Z","timestamp":1374481019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Surveillance study of species distribution, antifungal susceptibility and mortality of nosocomial candidemia in a tertiary care hospital in China"],"prefix":"10.1186","volume":"13","author":[{"given":"Chun-fang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-qiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-ning","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-an","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-qian","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"issue":"1","key":"2538_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1439-0507.2011.02044.x","volume":"55","author":"AM Tortorano","year":"2012","unstructured":"Tortorano AM, Dho G, Prigitano A, Breda G, Grancini A, Emmi V, Cavanna C, Marino G, Morero S, Ossi C: Invasive fungal infections in the intensive care unit: a multicentre, prospective, observational study in Italy (2006\u20132008). 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