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We described the incidence of invasive candidiasis in our hospital over 6\u00a0years and showed the antifungal susceptibility and genotypes of the isolated yeast.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>The yeast species were isolated on CHROMagar <jats:italic>Candida<\/jats:italic> medium and identified using an yeast identification card, followed by analysis of the D1\/D2 domain of 26S rDNA. The susceptibilities of the isolates to flucytosine, amphotericin B, fluconazole, itraconazole, and voriconazole were tested using the ATB FUNGUS 3 system, and that to caspofungin was tested using E-test strips. <jats:italic>C. albicans<\/jats:italic> was genotyped using single-strand conformation polymorphism of CAI (<jats:italic>Candida albicans<\/jats:italic> I) microsatellite DNA combined with GeneScan data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>From January 2006 to December 2011, a total of 259 isolates of invasive <jats:italic>Candida<\/jats:italic> spp. were obtained from 253 patients, among them 6 patients had multiple positive samples. Ninety-one stains were from blood and 168 from sterile fluids, accounting for 6.07% of all pathogens isolated in our hospital. Most of these strains were <jats:italic>C. albicans<\/jats:italic> (41.29% in blood\/59.06% in sterile body fluids), followed by <jats:italic>C. tropicalis<\/jats:italic> (18.06%\/25.72%), <jats:italic>C. parapsilosis<\/jats:italic> (17.42%\/5.43%), <jats:italic>C. glabrata<\/jats:italic> (11.61%\/3.99%) and other <jats:italic>Candida<\/jats:italic> spp. (11.61%\/5.80%). Most <jats:italic>Candida<\/jats:italic> spp. were isolated from the ICU. The new species-specific CLSI <jats:italic>candida<\/jats:italic> MIC breakpoints were applied to these date. Resistance to fluconazole occurred in 6.6% of <jats:italic>C. albicans<\/jats:italic> isolates, 10.6% of <jats:italic>C. tropicalis<\/jats:italic> isolates and 15.0% of <jats:italic>C. glabrata<\/jats:italic> isolates. For the 136 <jats:italic>C. albicans<\/jats:italic> isolates, 54 CAI patterns were recognized. The <jats:italic>C. albicans<\/jats:italic> strains from blood or sterile body fluids showed no predominant CAI genotypes. <jats:italic>C. albicans<\/jats:italic> isolates from different samples from the same patient had the same genotype.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Invasive candidiasis has been commonly encountered in our hospital in the past 6\u00a0years, with increasing frequency of non<jats:italic>-C. albicans<\/jats:italic>. Resistance to fluconazole was highly predictive of resistance to voriconazole. CAI SSCP genotyping showed that all <jats:italic>C. albicans<\/jats:italic> strains were polymorphic. Invasive candidiasis were commonly endogenous infection.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-13-353","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T12:43:18Z","timestamp":1375188198000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Surveillance of the prevalence, antibiotic susceptibility, and genotypic characterization of invasive candidiasis in a teaching hospital in China between 2006 to 2011"],"prefix":"10.1186","volume":"13","author":[{"given":"Fang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,7,30]]},"reference":[{"key":"2558_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1128\/CMR.00029-06","volume":"20","author":"MA Pfaller","year":"2007","unstructured":"Pfaller MA, Diekema DJ: Epidemiology of invasive candidiasis: a persistent public health problem. 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