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The prognostic implications of these serum biomarkers were also analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>One hundred TB patients and 92 IGRA-negative and 91 IGRA-positive family contacts were recruited. The DcR3 and PGE2 levels decreased from the IGRA-negative group to the IGRA-positive group, and peaked in the TB group. Lipoxin decreased to trough in the TB group. The three apoptosis serum markers and age were independent factors discriminating active TB from latent TB infection. In active TB, older age, co-morbidity, and higher serum DcR3 and monocyte chemotactic protein (MCP)-1 were independently associated with poorer six-month survival.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Apoptosis-associated serum biomarkers change along with the status of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection. In close contacts with positive IGRA, high DcR3 and PGE2 and low lipoxin may increase the probability of active TB. Older age, co-morbidity, and high DcR3 and MCP-1 levels might be important prognostic factors that warrant further investigation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-13-45","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T15:14:12Z","timestamp":1359386052000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Apoptosis-associated biomarkers in tuberculosis: promising for diagnosis and prognosis prediction"],"prefix":"10.1186","volume":"13","author":[{"given":"Chin-Chung","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Fang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Lin","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ta","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jann-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shie-Liang","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Jen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Na","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan-Chyr","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,28]]},"reference":[{"key":"2230_CR1","volume-title":"Global tuberculosis control: surveillance, planning, financing","author":"World Health Organization","year":"2008","unstructured":"World Health Organization: Global tuberculosis control: surveillance, planning, financing. 2008, Geneva, Switzerland: World Health Organization"},{"key":"2230_CR2","volume-title":"Group at risk: WHO report on the tuberculosis epidemic","author":"World Health Organization","year":"1996","unstructured":"World Health Organization: Group at risk: WHO report on the tuberculosis epidemic. 1996, Geneva, Switzerland: World Health Organization"},{"key":"2230_CR3","volume-title":"CDC annual report 2011","author":"FY Chang","year":"2011","unstructured":"Chang FY, Shih WY, Lin T, Chou JH, Chen YH, Liu DP, Yang CH, Chen CH, Yen CC, Wu HS, Wu PF, Cheng AH, Ke YF, Tien CF, Wu YH: CDC annual report 2011. 2011, Centers of Disease Control, Department of Health, R.O.C. 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