{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:49:03Z","timestamp":1788821343089,"version":"build-2803163510"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,10,5]],"date-time":"2013-10-05T00:00:00Z","timestamp":1380931200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Penicilliosis marneffei is increasingly observed in individuals without HIV infection. This study aimed to compare the clinical and laboratory features among HIV infected and uninfected individuals with penicilliosis marneffei.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study was conducted between January 1, 2007 and December 31, 2011 at Chiang Mai University Hospital. We included individuals who were \u226515 years of age and presented with culture-proven\n                      <jats:italic>P. marneffei<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>116 HIV-infected and 34 HIV-uninfected patients were enrolled. Comparing to HIV-infected patients, HIV-uninfected patients were older; less likely to have fever, splenomegaly, and umbilicated skin lesions; more likely to have Sweet\u2019s syndrome and bone and joint infections; had higher white blood cell count, platelet count, and CD4 cell count; had lower alanine transaminase (ALT); and less likely to have positive fungal blood cultures. The mortality rates were 20.7% and 29.4% among HIV infected and uninfected patients, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinical manifestations of penicilliosis marneffei are different between patients with and without HIV infection. Physician\u2019s awareness of this disease in HIV-uninfected patients may prompt the diagnosis and timely treatment, and can lead to a better outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2334-13-464","type":"journal-article","created":{"date-parts":[[2013,10,5]],"date-time":"2013-10-05T17:01:20Z","timestamp":1380992480000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":178,"title":["Clinical and laboratory characteristics of penicilliosis marneffei among patients with and without HIV infection in Northern Thailand: a retrospective study"],"prefix":"10.1186","volume":"13","author":[{"given":"Rathakarn","family":"Kawila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romanee","family":"Chaiwarith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khuanchai","family":"Supparatpinyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,10,5]]},"reference":[{"key":"4194_CR1","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1093\/cid\/cir028","volume":"52","author":"T Le","year":"2011","unstructured":"Le T, Wolbers M, Chi NH, Quang VM, Chinh NT, Lan NP, Lam PS, Kozal MJ, Shikuma CM, Day JN, Farrar J: Epidemiology, seasonality, and predictors of outcome of AIDS-associated Penicillium marneffei infection in Ho Chi Minh City, Viet Nam. Clin Infect Dis. 2011, 52: 945-952.","journal-title":"Clin Infect Dis"},{"key":"4194_CR2","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S0140-6736(94)91287-4","volume":"344","author":"K Supparatpinyo","year":"1994","unstructured":"Supparatpinyo K, Khamwan C, Baosoung V, Nelson KE, Sirisanthana T: Disseminated Penicillium marneffei infection in southeast Asia. Lancet. 1994, 344: 110-113.","journal-title":"Lancet"},{"key":"4194_CR3","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1093\/clinids\/14.4.871","volume":"14","author":"K Supparatpinyo","year":"1992","unstructured":"Supparatpinyo K, Chiewchanvit S, Hirunsri P, Uthammachai C, Nelson KE, Sirisanthana T: Penicillium marneffei infection in patients infected with human immunodeficiency virus. 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Hong Kong Med J. 2008, 14: 103-109.","journal-title":"Hong Kong Med J"},{"key":"4194_CR9","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1056\/NEJMoa1111160","volume":"367","author":"SK Browne","year":"2012","unstructured":"Browne SK, Burbelo PD, Chetchotisakd P, Suputtamongkol Y, Kiertiburanakul S, Shaw PA, Kirk JL, Jutivorakool K, Zaman R, Ding L, Hsu AP, Patel SY, Olivier KN, Lulitanond V, Mootsikapun P, Anunnatsiri S, Angkasekwinai N, Sathapatayavongs B, Hsueh PR, Shieh CC, Brown MR, Thongnoppakhun W, Claypool R, Sampaio EP, Thepthai C, Waywa D, Dacombe C, Reizes Y, Zelazny AM, Saleeb P: Adult-onset immunodeficiency in Thailand and Taiwan. 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