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We attempted to clarify whether <jats:italic>oipA<\/jats:italic> gene status is linked with PUD and\/or GC risks.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A systematically literature search was performed through four electronic databases. According to the specific inclusion and exclusion criteria, seven articles were ultimately available for the meta-analysis of <jats:italic>oipA<\/jats:italic> presence\/absence with PUD and GC, and eleven articles were included for the meta-analysis of <jats:italic>oipA<\/jats:italic> on\/off status with PUD and GC.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>For the on\/off functional status analysis of <jats:italic>oipA<\/jats:italic> gene, the \u201con\u201d status showed significant associations with increased risks of PUD (OR = 3.97, 95% CI: 2.89, 5.45; P &lt; 0.001) and GC (OR = 2.43, 95% CI: 1.45, 4.07; P = 0.001) compared with gastritis and functional dyspepsia controls. Results of the homogeneity test indicated different effects of <jats:italic>oipA<\/jats:italic> \u201con\u201d status on PUD risk between children and adult subgroups and on GC risk between PCR-sequencing and immunoblot subgroups. For the presence\/absence analysis of <jats:italic>oipA<\/jats:italic> gene, we found null association of the presence of <jats:italic>oipA<\/jats:italic> gene with the risks of PUD (OR = 1.93, 95% CI: 0.60, 6.25; P = 0.278) and GC (OR = 2.09, 95% CI: 0.51, 8.66; P = 0.308) compared with gastritis and functional dyspepsia controls.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>To be concluded, when <jats:italic>oipA<\/jats:italic> exists, the functional \u201con\u201d status of this gene showed association with increased risks for PUD and GC compared with gastritis and FD controls. However, merely investigating the presence\/absence of <jats:italic>oipA<\/jats:italic> would overlook the importance of its functional on\/off status and would not be reliable to predict risks of PUD and GC. Further large-scale and well-designed studies concerning on\/off status of <jats:italic>oipA<\/jats:italic> are required to confirm our meta-analysis results.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-13-555","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T14:07:41Z","timestamp":1384956461000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Association of presence\/absence and on\/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis"],"prefix":"10.1186","volume":"13","author":[{"given":"Jingwei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhong","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"2750_CR1","doi-asserted-by":"publisher","first-page":"371503","DOI":"10.1155\/2012\/371503","volume":"2012","author":"Y Yamaoka","year":"2012","unstructured":"Yamaoka Y: Pathogenesis of Helicobacter pylori-related gastroduodenal diseases from molecular epidemiological studies. 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