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The objective of this study was to examine the epidemiology of EPTB in Brazil between 2007 and 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross-sectional study involving all cases of TB reported to the Brazilian Notifiable Diseases Surveillance System (Sistema de Informa\u00e7\u00f5es de Agravo de Notifica\u00e7\u00e3o - SINAN) in Brazil between 2007 and 2011. Sociodemographic and clinical characteristics of patients with exclusively PTB and exclusively EPTB were compared. Following analysis with Pearson\u2019s chi-square test, variables with p\u2009&lt;\u20090.05 were included in a hierarchical regression model. Variables with p\u2009&lt;\u20090.05 in the corresponding level were kept in the model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 427,548 cases of TB were included. Of these, 356,342 cases (83.35%; 95% confidence interval (CI) 83.23% - 83.45%) were PTB, 57,217 (13.37%; 95% CI 13.28% - 13.48%) were EPTB, 13,989 (3.27%; 95% CI 3.21% - 3.32%) were concurrent pulmonary and extrapulmonary TB. Patients with EPTB were mainly white (16.7%), and most (29.1%) patients had five to eight years of education. Among comorbidities, HIV infection was prominent (OR 2.15; 95% CI 2.09 \u2013 2.21), although the proportion of cases awaiting test results or untested was high (39%). Ethanol use (OR 0.45; 95% CI 0.43 \u2013 0.46), diabetes mellitus (OR 0.54; 95% CI 0.51 \u2013 0.57) and mental illness (OR 0.88; 95% CI 0.82 \u2013 0.95) were associated with PTB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thirteen percent of patients diagnosed with TB in Brazil have only EPTB. 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