{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:40:04Z","timestamp":1762864804906},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T00:00:00Z","timestamp":1092355200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Geohelminth infection is a major health problem of children from rural areas of developing countries. In an attempt to reduce this burden, the Department of Health of the province of KwaZulu-Natal (KZN) established in 1998 a programme for helminth control that aimed at regularly treating primary school children for schistosomiasis and intestinal helminths. This article describes the baseline situation and the effect of treatment on geohelminth infection in a rural part of the province.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Grade 3 schoolchildren from Maputaland in northern KZN were examined for infections with hookworm, <jats:italic>Ascaris lumbricoides<\/jats:italic>, and <jats:italic>Trichuris trichiura<\/jats:italic>, treated twice with 400 mg albendazole and re-examined several times over one year after the first treatment in order to assess the impact of treatment and patterns of infection and re-infection.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The hookworm prevalence in the study population (83.2%) was considerably higher than in other parts of the province whereas <jats:italic>T. trichiura<\/jats:italic> and especially <jats:italic>A. lumbricoides<\/jats:italic> prevalences (57.2 and 19.4%, respectively) were much lower than elsewhere on the KZN coastal plain. Single dose treatment with albendazole was very effective against hookworm and <jats:italic>A. lumbricoides<\/jats:italic> with cure rates (CR) of 78.8 and 96.4% and egg reduction rates (ERR) of 93.2 and 97.7%, respectively. It was exceptionally ineffective against <jats:italic>T. trichiura<\/jats:italic> (CR = 12.7%, ERR = 24.8%). Re-infection with hookworm and <jats:italic>A. lumbricoides<\/jats:italic> over 29 weeks after treatment was considerable but still well below pre-treatment levels.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>High geohelminth prevalences and re-infection rates in the study population confirm the need for regular treatment of primary school children in the area. The low effectiveness of single course albendazole treatment against <jats:italic>T. trichiura<\/jats:italic> infection however demands consideration of alternative treatment approaches.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1471-2334-4-27","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T06:23:03Z","timestamp":1092810183000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Patterns of geohelminth infection, impact of albendazole treatment and re-infection after treatment in schoolchildren from rural KwaZulu-Natal\/South-Africa"],"prefix":"10.1186","volume":"4","author":[{"given":"Elmar","family":"Saathoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane D","family":"Kvalsvig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris C","family":"Appleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,8,13]]},"reference":[{"key":"112_CR1","volume-title":"Impact of helminth infections on human nutrition","author":"LS Stephenson","year":"1987","unstructured":"Stephenson LS: Impact of helminth infections on human nutrition. 1987, London: Taylor & Francis"},{"key":"112_CR2","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0035-9203(98)90795-7","volume":"92","author":"A Olsen","year":"1998","unstructured":"Olsen A, Magnussen P, Ouma JH, Andreassen J, Friis H: The contribution of hookworm and other parasitic infections to haemoglobin and iron status among children and adults in western Kenya. 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