{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:01:35Z","timestamp":1761487295044},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T00:00:00Z","timestamp":1102896000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T00:00:00Z","timestamp":1102896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Management of patients with bleeding oesophageal varices comprises of mainly diagnostic endoscopy, sclerotherapy and band ligation. One of the major problems to do any of the above is the active bleeding which makes any intervention difficult. The neuropeptide hormone somatostatin administered exogenously has caused a reduction in portal hypertension and variceal bleeding in patients suffering from liver cirrhosis. We believe that the symptomatic use of somatostatin for variceal bleeding in <jats:italic>Schistosoma mansoni<\/jats:italic> infected subjects can reduce bleeding, thereby alleviating the pathology caused by schistosomiasis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods\/design<\/jats:title>\n                        <jats:p>We herein present a study protocol for establishing this neuropeptide as a potential therapeutic agent in schistosomiasis. Adolescent subjects, age range varying from 12\u201317 years will be selected, based on several inclusion criteria, most important being infection with <jats:italic>Schistosoma mansoni<\/jats:italic> with bleeding from oesophageal varices in the last 24 hours. One group of schistosomiasis patients will be treated with somatostatin and praziquantel, the other with propanolol and praziquantel. Survival graphs will be set up to correlate somatostatin administration with survival time. A two part questionnaire will be set up to control treatment outcomes. The pre-treatment part of the clinical questionnaire will identify inclusion criteria questions, the post-treatment part of the questionnaire will identify treatment outcomes.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Discussion<\/jats:title>\n                        <jats:p>We expect that the administration of somatostatin as a bolus followed by a 24 hour long infusion, will stop bleeding immediately, delay rebleeding as compared to the control study group and delay mortality in the somatostatin treated subjects.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1471-2334-4-58","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T14:51:15Z","timestamp":1105627875000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Can somatostatin control acute bleeding from oesophageal varices in Schistosoma mansoni patients?[ISRCTN63456799]"],"prefix":"10.1186","volume":"4","author":[{"given":"Shyama","family":"Chatterjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Van Marck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,12,13]]},"reference":[{"key":"143_CR1","first-page":"1","volume":"830","author":"WHO Expert Committee","year":"1983","unstructured":"WHO Expert Committee: The control of schistosomiasis. WHO Tech Rep Ser. 1983, 830: 1-86.","journal-title":"WHO Tech Rep Ser"},{"key":"143_CR2","unstructured":"Fevery J, Raptis SA: 'Optimal management of upper gastrointestinal bleeding'. in Research and Clinical forums. 1997, 19 (8):"},{"key":"143_CR3","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/S0140-6736(97)05099-X","volume":"350","author":"A Avgerinos","year":"1997","unstructured":"Avgerinos A, Nevens F, Raptis S, Fevery J: Early administration of somatostatin and efficacy of sclerotherapy in acute oesophageal variceal bleeds: The European Acute Bleeding Oesophageal Variceal Episodes (ABOVE) randomised trial. Lancet. 1997, 350: 1495-1499. 10.1016\/S0140-6736(97)05099-X.","journal-title":"Lancet"},{"key":"143_CR4","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1136\/bmj.295.6593.288","volume":"295","author":"SR Bloom","year":"1987","unstructured":"Bloom SR, Polak J: Somatostatin. 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Somatoselective. 2003, 2: 10-","journal-title":"Somatoselective"},{"key":"143_CR7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1046\/j.1365-3156.2003.00989.x","volume":"8","author":"S Chatterjee","year":"2003","unstructured":"Chatterjee S, Mbaye A, Van Marck EAE: Lower levels of the circulating neuropeptide somatostatin in S. mansoni infected patients may have pathological significance. Trop Med Int Health. 2003, 8: 33-36. 10.1046\/j.1365-3156.2003.00989.x.","journal-title":"Trop Med Int Health"},{"key":"143_CR8","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S1471-4922(02)02294-8","volume":"18","author":"S Chatterjee","year":"2002","unstructured":"Chatterjee S, Mbaye A, De Man JG, Van Marck EAE: Does the neuropeptide somatostatin have therapeutic potential in schistosomiasis?. Trends Parasitol. 2002, 18: 295-298. 10.1016\/S1471-4922(02)02294-8.","journal-title":"Trends Parasitol"},{"key":"143_CR9","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1046\/j.1365-3156.2001.00758.x","volume":"6","author":"S Chatterjee","year":"2001","unstructured":"Chatterjee S, Van Marck E: The role of somatostatin in schistosomiasis: a basis for immunomodulation in host-parasite interactions?. Trop Med Int Health. 2001, 6: 578-581. 10.1046\/j.1365-3156.2001.00758.x.","journal-title":"Trop Med Int Health"},{"key":"143_CR10","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1046\/j.1365-3156.2001.00744.x","volume":"6","author":"S Chatterjee","year":"2001","unstructured":"Chatterjee S, De Man JG, Van Marck EAE: Somatostatin and intestinal schistosomiasis: therapeutic and neuropathological implications in host-parasite interactions. Trop Med Int Health. 2001, 6: 1008-1015. 10.1046\/j.1365-3156.2001.00744.x.","journal-title":"Trop Med Int Health"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-4-58.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/1471-2334-4-58\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-4-58","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-4-58.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:44:17Z","timestamp":1728305057000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/1471-2334-4-58"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,13]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,12]]}},"alternative-id":["143"],"URL":"https:\/\/doi.org\/10.1186\/1471-2334-4-58","relation":{},"ISSN":["1471-2334"],"issn-type":[{"type":"electronic","value":"1471-2334"}],"subject":[],"published":{"date-parts":[[2004,12,13]]},"assertion":[{"value":"15 November 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"58"}}