{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:53:39Z","timestamp":1778032419867,"version":"3.51.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The functional polymorphism -260 C&gt;T in the LPS sensing TLR4 co-receptor <jats:italic>CD14<\/jats:italic> gene enhances the transcriptional activity and results in a higher CD14 receptor density. Individuals carrying the T\/T genotype also have significantly higher serum levels of soluble CD14. The T allele of this polymorphism has recently been linked to <jats:italic>Chlamydia pneumoniae<\/jats:italic> infection. We investigated the role of the <jats:italic>CD14<\/jats:italic> -260 C&gt;T polymorphism in the susceptibility to and severity (defined as subfertility and\/or tubal pathology) of <jats:italic>C. trachomatis<\/jats:italic> infection in Dutch Caucasian women.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The different <jats:italic>CD14<\/jats:italic> -260 C&gt;T genotypes were assessed by PCR-based RFLP analysis in three cohorts: 1) A cohort (n = 576) of women attending a STD clinic, 2) a cohort (n = 253) of women with subfertility, and 3) an ethnically matched control cohort (n = 170). The following variables were used in the analysis: In cohort 1 the CT-DNA status, CT IgG serology status, self-reported symptoms and in cohort 2, the CT IgG serology status and the tubal status at laparoscopy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the control cohort the CC, CT and TT genotype distribution was: 28.2%, 48.2%, and 23.5% respectively. No differences were found in the overall prevalence of <jats:italic>CD14<\/jats:italic> -260 genotypes (28.1%, 50.7%, and 21.2%) in cohort 1 when compared to the control cohort. Also no differences were observed in women with or without CT-DNA, with or without serological CT responses, with or without symptoms, or in combinations of these three variables. In subfertile women with tubal pathology (cohort 2, n = 50) the genotype distribution was 28.0%, 48.0%, and 24.0% and in subfertile women without tubal pathology (n = 203), 27.6%, 49.3% and 23.2%. The genotype distribution was unchanged when CT IgG status was introduced in the analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The <jats:italic>CD14<\/jats:italic> -260 C&gt;T genotype distributions were identical in all three cohorts, showing that this polymorphism is not involved in the susceptibility to or severity of sequelae of <jats:italic>C. trachomatis<\/jats:italic> infection.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-5-114","type":"journal-article","created":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T14:14:34Z","timestamp":1135088074000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The CD14 functional gene polymorphism -260 C&gt;T is not involved in either the susceptibility to Chlamydia trachomatis infection or the development of tubal pathology"],"prefix":"10.1186","volume":"5","author":[{"given":"Sander","family":"Ouburg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joke","family":"Spaargaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneke E","family":"den Hartog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolande A","family":"Land","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan SA","family":"Fennema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolein","family":"Pleijster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Salvador","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Servaas A","family":"Morr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the ICTI consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,12,20]]},"reference":[{"key":"262_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2334-3-2","volume":"3","author":"K Numazaki","year":"2003","unstructured":"Numazaki K, Asanuma H, Niida Y: Chlamydia trachomatis infection in early neonatal period. 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