{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:01:50Z","timestamp":1780470110865,"version":"3.54.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T00:00:00Z","timestamp":1112659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T00:00:00Z","timestamp":1112659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>An association between Henoch-Schonlein purpura (HSP) and seropositivity for <jats:italic>Bartonella henselae (<\/jats:italic>BH) has been described. The objective of this study was to see if such an association exists in northern Alberta.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Immunofluorescent antibody testing utilizing an antigen prepared from <jats:italic>B. henselae<\/jats:italic> was undertaken on sera from six children with current HSP, 22 children with remote HSP, and 28 controls that were matched for age. Blood from the six children with current HSP was analysed by polymerase chain reaction (PCR) assay with primers derived from the citrate synthase (gltA) gene for the detection of <jats:italic>Bartonella<\/jats:italic> DNA.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The seropositivity rate for BH was 61% in cases versus 21% in controls (p &lt; 0.03). The PCR assay was negative in all six current cases.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>There is an increased seropositivity rate for BH in children with HSP. However, it is not clear if infection with <jats:italic>B. henselae<\/jats:italic> or a related <jats:italic>Bartonella<\/jats:italic> species can result in HSP, or if the increased seropositivity is from non-specific or cross-reacting antibodies.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1471-2334-5-21","type":"journal-article","created":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T06:13:42Z","timestamp":1112681622000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Bartonella seropositivity in children with Henoch-Schonlein purpura"],"prefix":"10.1186","volume":"5","author":[{"given":"Joan L","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W","family":"Spady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errol","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"McColl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Artsob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,4,5]]},"reference":[{"key":"169_CR1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1136\/adc.80.4.380","volume":"80","author":"EJ Tizard","year":"1999","unstructured":"Tizard EJ: Henoch-Schonlein Purpura. 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