{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:23:48Z","timestamp":1775197428781,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T00:00:00Z","timestamp":1105660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T00:00:00Z","timestamp":1105660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Enterococcal meningitis is an uncommon disease usually caused by <jats:italic>Enterococcus faecalis<\/jats:italic> and <jats:italic>Enterococcus faecium<\/jats:italic> and is associated with a high mortality rate. <jats:italic>Enterococcus casseliflavus<\/jats:italic> has been implicated in a wide variety of infections in humans, but never in meningitis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Case presentation<\/jats:title>\n                        <jats:p>A 77-year-old Italian female presented for evaluation of fever, stupor, diarrhea and vomiting of 3 days duration. There was no history of head injury nor of previous surgical procedures. She had been suffering from rheumatoid arthritis for 30 years, for which she was being treated with steroids and methotrexate. On admission, she was febrile, alert but not oriented to time and place. Her neck was stiff, and she had a positive Kernig's sign. The patient's cerebrospinal fluid was opalescent with a glucose concentration of 14 mg\/dl, a protein level of 472 mg\/dl, and a white cell count of 200\/\u03bcL with 95% polymorphonuclear leukocytes and 5% lymphocytes. Gram staining of CSF revealed no organisms, culture yielded <jats:italic>E. casseliflavus<\/jats:italic>. The patient was successfully treated with meropenem and ampicillin-sulbactam.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p><jats:italic>E. casseliflavus<\/jats:italic> can be inserted among the etiologic agents of meningitis. Awareness of infection of central nervous system with <jats:italic>Enterococcus<\/jats:italic> species that possess an intrinsic vancomycin resistance should be increased.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1471-2334-5-3","type":"journal-article","created":{"date-parts":[[2005,1,18]],"date-time":"2005-01-18T07:25:09Z","timestamp":1106033109000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Enterococcal meningitis caused by Enterococcus casseliflavus. First case report"],"prefix":"10.1186","volume":"5","author":[{"given":"Chiara","family":"Iaria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Stassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano Bruno","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Di Leo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Toscano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Cascio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,1,14]]},"reference":[{"key":"151_CR1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/01.md.0000090402.56130.82","volume":"82","author":"V Pintado","year":"2003","unstructured":"Pintado V, Cabellos C, Moreno S, Meseguer MA, Ayats J, Viladrich PF: Enterococcal meningitis: a clinical study of 39 cases and review of the literature. Medicine (Baltimore). 2003, 82: 346-364. 10.1097\/01.md.0000090402.56130.82.","journal-title":"Medicine (Baltimore)"},{"key":"151_CR2","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0213-005X(03)72937-1","volume":"21","author":"F Gascon","year":"2003","unstructured":"Gascon F, Castano MA, Gonzalez A, Cordon MD: Endocarditis due to Enterococcus casseliflavus. Enferm Infecc Microbiol Clin. 2003, 21: 275-276. 10.1157\/13046550.","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"151_CR3","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1086\/517774","volume":"28","author":"W Ratanasuwan","year":"1999","unstructured":"Ratanasuwan W, Iwen PC, Hinrichs SH, Rupp ME: Bacteremia due to motile Enterococcus species: clinical features and outcomes. Clin Infect Dis. 1999, 28: 1175-1177.","journal-title":"Clin Infect Dis"},{"key":"151_CR4","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1086\/320542","volume":"32","author":"KC Reid","year":"2001","unstructured":"Reid KC, Cockerill IF, Patel R: Clinical and epidemiological features of Enterococcus casseliflavus\/flavescens and Enterococcus gallinarum bacteremia: a report of 20 cases. Clin Infect Dis. 2001, 32: 1540-1546. 10.1086\/320542.","journal-title":"Clin Infect Dis"},{"key":"151_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1086\/380452","volume":"38","author":"SH Choi","year":"2004","unstructured":"Choi SH, Lee SO, Kim TH, et al: Clinical features and outcomes of bacteremia caused by Enterococcus casseliflavus and Enterococcus gallinarum: analysis of 56 cases. Clin Infect Dis. 2004, 38: 53-61. 10.1086\/380452.","journal-title":"Clin Infect Dis"},{"key":"151_CR6","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1128\/JCM.39.2.820-822.2001","volume":"39","author":"A Kurup","year":"2001","unstructured":"Kurup A, Tee WS, Loo LH, Lin R: Infection of central nervous system by motile Enterococcus: first case report. J Clin Microbiol. 2001, 39: 820-822. 10.1128\/JCM.39.2.820-822.2001.","journal-title":"J Clin Microbiol"},{"key":"151_CR7","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s10156-003-0268-0","volume":"9","author":"Y Takayama","year":"2003","unstructured":"Takayama Y, Sunakawa K, Akahoshi T: Meningitis caused by Enterococcus gallinarum in patients with ventriculoperitoneal shunts. J Infect Chemother. 2003, 9: 348-350. 10.1007\/s10156-003-0268-0.","journal-title":"J Infect Chemother"},{"key":"151_CR8","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1128\/jcm.35.12.3166-3170.1997","volume":"35","author":"B Toye","year":"1997","unstructured":"Toye B, Shymanski J, Bobrowska M, Woods W, Ramotar K: Clinical and epidemiological significance of enterococci intrinsically resistant to vancomycin (possessing the vanC genotype). J Clin Microbiol. 1997, 35: 3166-3170.","journal-title":"J Clin Microbiol"},{"key":"151_CR9","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0002-9343(99)80270-8","volume":"102","author":"BE Murray","year":"1997","unstructured":"Murray BE: Vancomycin-resistant enterococci. Am J Med. 1997, 102: 284-293. 10.1016\/S0002-9343(99)80270-8.","journal-title":"Am J Med"},{"key":"151_CR10","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1093\/clind\/24.4.545","volume":"24","author":"R Leclercq","year":"1997","unstructured":"Leclercq R, Courvalin P: Resistance to glycopeptides in enterococci. Clin Infect Dis. 1997, 24: 545-554.","journal-title":"Clin Infect Dis"},{"key":"151_CR11","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/clinids\/20.3.725","volume":"20","author":"BA Fazal","year":"1995","unstructured":"Fazal BA, Turett GS, Chilimuri SS, Mendoza CM, Telzak EE: Community-acquired enterococcal meningitis in an adult. Clin Infect Dis. 1995, 20: 725-726.","journal-title":"Clin Infect Dis"},{"key":"151_CR12","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0732-8893(98)00052-2","volume":"31","author":"KG Van Horn","year":"1998","unstructured":"Van Horn KG, Rodney KM: Colonization and microbiology of the motile enterococci in a patient population. Diagn Microbiol Infect Dis. 1998, 31: 525-530. 10.1016\/S0732-8893(98)00052-2.","journal-title":"Diagn Microbiol Infect Dis"},{"key":"151_CR13","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1128\/jcm.33.11.2842-2846.1995","volume":"33","author":"B Gordts","year":"1995","unstructured":"Gordts B, Van Landuyt H, Ieven M, Vandamme P, Goossens H: Vancomycin-resistant enterococci colonizing the intestinal tracts of hospitalized patients. J Clin Microbiol. 1995, 33: 2842-2846.","journal-title":"J Clin Microbiol"},{"key":"151_CR14","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1086\/513755","volume":"25","author":"C Edlund","year":"1997","unstructured":"Edlund C, Barkholt L, Olsson-Liljequist B, Nord CE: Effect of vancomycin on intestinal flora of patients who previously received antimicrobial therapy. Clin Infect Dis. 1997, 25: 729-732.","journal-title":"Clin Infect Dis"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-5-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/1471-2334-5-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-5-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-5-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:39:39Z","timestamp":1728304779000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/1471-2334-5-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,14]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,12]]}},"alternative-id":["151"],"URL":"https:\/\/doi.org\/10.1186\/1471-2334-5-3","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,14]]},"assertion":[{"value":"24 July 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"3"}}