{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:17:26Z","timestamp":1772626646450,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1186\/1471-2334-6-175","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T19:18:42Z","timestamp":1166037522000},"source":"Crossref","is-referenced-by-count":47,"title":["Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis"],"prefix":"10.1186","volume":"6","author":[{"given":"Hans-Olav","family":"Fjaerli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir","family":"Bukholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Krog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Skjaeret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marit","family":"Holden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Nakstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,12,13]]},"reference":[{"key":"439_CR1","doi-asserted-by":"publisher","first-page":"S119","DOI":"10.1016\/S1526-0542(04)90023-1","volume":"5 Suppl A","author":"PL Ogra","year":"2004","unstructured":"Ogra PL: Respiratory syncytial virus: the virus, the disease and the immune response. Paediatr Respir Rev. 2004, 5 Suppl A: S119-S126. 10.1016\/S1526-0542(04)90023-1.","journal-title":"Paediatr Respir Rev"},{"key":"439_CR2","first-page":"209","volume":"48","author":"CP Black","year":"2003","unstructured":"Black CP: Systematic review of the biology and medical management of respiratory syncytial virus infection. Respir Care. 2003, 48: 209-231.","journal-title":"Respir Care"},{"key":"439_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nm1164","volume":"11","author":"V Bitko","year":"2005","unstructured":"Bitko V, Musiyenko A, Shulyayeva O, Barik S: Inhibition of respiratory viruses by nasally administered siRNA. Nat Med. 2005, 11: 50-55. 10.1038\/nm1164.","journal-title":"Nat Med"},{"key":"439_CR4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nm1174","volume":"11","author":"W Zhang","year":"2005","unstructured":"Zhang W, Yang H, Kong X, Mohapatra S, San Juan-Vergara H, Hellermann G, Behera S, Singam R, Lockey RF, Mohapatra SS: Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nat Med. 2005, 11: 56-62. 10.1038\/nm1174.","journal-title":"Nat Med"},{"key":"439_CR5","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/35015701","volume":"405","author":"DJ Lockhart","year":"2000","unstructured":"Lockhart DJ, Winzeler EA: Genomics, gene expression and DNA arrays. Nature. 2000, 405: 827-836. 10.1038\/35015701.","journal-title":"Nature"},{"key":"439_CR6","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.mam.2005.12.007","volume":"27","author":"M Kubista","year":"2006","unstructured":"Kubista M, Andrade JM, Bengtsson M, Forootan A, Jonak J, Lind K, Sindelka R, Sjoback R, Sjogreen B, Strombom L, Stahlberg A, Zoric N: The real-time polymerase chain reaction. Mol Aspects Med. 2006, 27: 95-125. 10.1016\/j.mam.2005.12.007.","journal-title":"Mol Aspects Med"},{"key":"439_CR7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/0045-9380(93)90003-U","volume":"23","author":"O Ruuskanen","year":"1993","unstructured":"Ruuskanen O, Ogra PL: Respiratory syncytial virus. Curr Probl Pediatr. 1993, 23: 50-79. 10.1016\/0045-9380(93)90003-U.","journal-title":"Curr Probl Pediatr"},{"key":"439_CR8","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1128\/JCM.39.5.1696-1701.2001","volume":"39","author":"SC Kehl","year":"2001","unstructured":"Kehl SC, Henrickson KJ, Hua W, Fan J: Evaluation of the Hexaplex assay for detection of respiratory viruses in children. J Clin Microbiol. 2001, 39: 1696-1701. 10.1128\/JCM.39.5.1696-1701.2001.","journal-title":"J Clin Microbiol"},{"key":"439_CR9","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/S0022-3476(95)70547-3","volume":"126","author":"EE Wang","year":"1995","unstructured":"Wang EE, Law BJ, Stephens D: Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection. J Pediatr. 1995, 126: 212-219. 10.1016\/S0022-3476(95)70547-3.","journal-title":"J Pediatr"},{"key":"439_CR10","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1007\/s00134-002-1256-z","volume":"28","author":"L Bont","year":"2002","unstructured":"Bont L, Kimpen JL: Immunological mechanisms of severe respiratory syncytial virus bronchiolitis. Intensive Care Med. 2002, 28: 616-621. 10.1007\/s00134-002-1256-z.","journal-title":"Intensive Care Med"},{"key":"439_CR11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1053\/jinf.2002.1015","volume":"45","author":"D Hacking","year":"2002","unstructured":"Hacking D, Hull J: Respiratory syncytial virus--viral biology and the host response. J Infect. 2002, 45: 18-24. 10.1053\/jinf.2002.1015.","journal-title":"J Infect"},{"key":"439_CR12","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1365-2249.2004.02504.x","volume":"137","author":"JH Aberle","year":"2004","unstructured":"Aberle JH, Aberle SW, Rebhandl W, Pracher E, Kundi M, Popow-Kraupp T: Decreased interferon-gamma response in respiratory syncytial virus compared to other respiratory viral infections in infants. Clin Exp Immunol. 2004, 137: 146-150. 10.1111\/j.1365-2249.2004.02504.x.","journal-title":"Clin Exp Immunol"},{"key":"439_CR13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1365-2249.2004.02582.x","volume":"138","author":"U Schauer","year":"2004","unstructured":"Schauer U, Hoffjan S, Rothoeft T, Bartz H, Konig S, Fuchs E, Bittscheidt J, Kochling A, Stephan V: Severe respiratory syncytial virus infections and reduced interferon-gamma generation in vitro. Clin Exp Immunol. 2004, 138: 102-109. 10.1111\/j.1365-2249.2004.02582.x.","journal-title":"Clin Exp Immunol"},{"key":"439_CR14","doi-asserted-by":"publisher","first-page":"10190","DOI":"10.1128\/JVI.79.16.10190-10199.2005","volume":"79","author":"A Guerrero-Plata","year":"2005","unstructured":"Guerrero-Plata A, Baron S, Poast JS, Adegboyega PA, Casola A, Garofalo RP: Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections. J Virol. 2005, 79: 10190-10199. 10.1128\/JVI.79.16.10190-10199.2005.","journal-title":"J Virol"},{"key":"439_CR15","first-page":"14","volume":"25","author":"SJ Haque","year":"1998","unstructured":"Haque SJ, Williams BR: Signal transduction in the interferon system. Semin Oncol. 1998, 25: 14-22.","journal-title":"Semin Oncol"},{"key":"439_CR16","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.1128\/JVI.76.9.4287-4293.2002","volume":"76","author":"B Bossert","year":"2002","unstructured":"Bossert B, Conzelmann KK: Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cells. J Virol. 2002, 76: 4287-4293. 10.1128\/JVI.76.9.4287-4293.2002.","journal-title":"J Virol"},{"key":"439_CR17","doi-asserted-by":"publisher","first-page":"5241","DOI":"10.1128\/JVI.79.9.5241-5248.2005","volume":"79","author":"KK Conzelmann","year":"2005","unstructured":"Conzelmann KK: Transcriptional activation of alpha\/beta interferon genes: interference by nonsegmented negative-strand RNA viruses. J Virol. 2005, 79: 5241-5248. 10.1128\/JVI.79.9.5241-5248.2005.","journal-title":"J Virol"},{"key":"439_CR18","doi-asserted-by":"publisher","first-page":"5947","DOI":"10.1046\/j.0014-2956.2001.02545.x","volume":"268","author":"PM Martensen","year":"2001","unstructured":"Martensen PM, Sogaard TM, Gjermandsen IM, Buttenschon HN, Rossing AB, Bonnevie-Nielsen V, Rosada C, Simonsen JL, Justesen J: The interferon alpha induced protein ISG12 is localized to the nuclear membrane. Eur J Biochem. 2001, 268: 5947-5954. 10.1046\/j.0014-2956.2001.02545.x.","journal-title":"Eur J Biochem"},{"key":"439_CR19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-2164-5-8","volume":"5","author":"N Parker","year":"2004","unstructured":"Parker N, Porter AC: Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12. BMC Genomics. 2004, 5: 8-10.1186\/1471-2164-5-8.","journal-title":"BMC Genomics"},{"key":"439_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/107999004772719864","volume":"24","author":"PM Martensen","year":"2004","unstructured":"Martensen PM, Justesen J: Small ISGs coming forward. J Interferon Cytokine Res. 2004, 24: 1-19. 10.1089\/107999004772719864.","journal-title":"J Interferon Cytokine Res"},{"key":"439_CR21","doi-asserted-by":"publisher","first-page":"11688","DOI":"10.1128\/JVI.76.22.11688-11703.2002","volume":"76","author":"L Labrada","year":"2002","unstructured":"Labrada L, Liang XH, Zheng W, Johnston C, Levine B: Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12. J Virol. 2002, 76: 11688-11703. 10.1128\/JVI.76.22.11688-11703.2002.","journal-title":"J Virol"},{"key":"439_CR22","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1046\/j.1365-2222.2001.01138.x","volume":"31","author":"A Egesten","year":"2001","unstructured":"Egesten A, Calafat J, Janssen H, Knol EF, Malm J, Persson T: Granules of human eosinophilic leucocytes and their mobilization. Clin Exp Allergy. 2001, 31: 1173-1188. 10.1046\/j.1365-2222.2001.01138.x.","journal-title":"Clin Exp Allergy"},{"key":"439_CR23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/CMR.12.2.298","volume":"12","author":"JB Domachowske","year":"1999","unstructured":"Domachowske JB, Rosenberg HF: Respiratory syncytial virus infection: immune response, immunopathogenesis, and treatment. Clin Microbiol Rev. 1999, 12: 298-309.","journal-title":"Clin Microbiol Rev"},{"key":"439_CR24","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1136\/adc.76.3.210","volume":"76","author":"RL Smyth","year":"1997","unstructured":"Smyth RL, Fletcher JN, Thomas HM, Hart CA: Immunological responses to respiratory syncytial virus infection in infancy. Arch Dis Child. 1997, 76: 210-214.","journal-title":"Arch Dis Child"},{"key":"439_CR25","first-page":"CR493","volume":"11","author":"KN Priftis","year":"2005","unstructured":"Priftis KN, Papadopoulou A, Liatsis E, Katsikas D, Nicolaidou P, Kanariou M: Serum eosinophil cationic protein and CD23 in acute RSV bronchiolitis. Med Sci Monit. 2005, 11: CR493-CR497.","journal-title":"Med Sci Monit"},{"key":"439_CR26","doi-asserted-by":"publisher","first-page":"355S","DOI":"10.1378\/chest.123.3_suppl.355S","volume":"123","author":"SJ Ackerman","year":"2003","unstructured":"Ackerman SJ, Kwatia MA, Doyle CB, Enhorning G: Hydrolysis of surfactant phospholipids catalyzed by phospholipase A2 and eosinophil lysophospholipases causes surfactant dysfunction: a mechanism for small airway closure in asthma. Chest. 2003, 123: 355S-10.1378\/chest.123.3_suppl.355S.","journal-title":"Chest"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2334-6-175\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-6-175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-6-175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-6-175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T06:33:01Z","timestamp":1548138781000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/1471-2334-6-175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["439"],"URL":"https:\/\/doi.org\/10.1186\/1471-2334-6-175","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]},"article-number":"175"}}