{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:18:57Z","timestamp":1779110337593,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,3,16]],"date-time":"2006-03-16T00:00:00Z","timestamp":1142467200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>A long-term active surveillance of Q fever was conducted in Cyprus organized in two phases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Following serological tests and identification of seropositive humans and animals for <jats:italic>C. burnetii<\/jats:italic> in two villages (VIL1 and VIL2), all seronegative individuals were followed up for one year on a monthly basis by trained physicians to detect possible seroconversion for Q fever. In the second phase of the study, active surveillance for one year was conducted in the entire Cyprus. Physicians were following specific case definition criteria for Q fever. Standardized questionnaires, a geographical information system on a regional level, Immunofluorescence Assay (IFA) examinations and shell vial technique were used.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Eighty-one seronegative humans and 239 seronegative animals from both villages participated in the first phase surveillance period of Q fever. Despite the small number of confirmed clinical cases (2 humans and 1 goat), a significant percentage of new seropositives for <jats:italic>C. burnetii<\/jats:italic> (44.4% of human participants and 13.8% of animals) was detected at the end of the year. During the second phase of surveillance, 82 humans, 100 goats, and 76 sheep were considered suspected cases of Q fever. However, only 9 human, 8 goat, and 4 sheep cases were serologically confirmed, while <jats:italic>C. burnetii<\/jats:italic> was isolated from three human and two animal samples. The human incidence rate was estimated at 1.2 per 100,000 population per year.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>A small number of confirmed clinical cases of Q fever were observed despite the high seroprevalence for <jats:italic>C. burnetii<\/jats:italic> in human and animal population of Cyprus. Most of the cases in the local population of Cyprus appear to be subclinical. Moreover further studies should investigate the role of ticks in the epidemiology of Q fever and their relation to human seropositivity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-6-48","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T12:46:50Z","timestamp":1144327610000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Active surveillance of Q fever in human and animal population of Cyprus"],"prefix":"10.1186","volume":"6","author":[{"given":"Fidias","family":"Loukaides","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Hadjichristodoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elpidoforos S","family":"Soteriades","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Kolonia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Christina","family":"Ioannidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Psaroulaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannis","family":"Tselentis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,3,16]]},"reference":[{"key":"312_CR1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/BF01647731","volume":"15","author":"ID Aitken","year":"1987","unstructured":"Aitken ID, Bogel K, Cracea E, Edlinger E, Houwers D, Krauss H, Rady M, Rehacek J, Schiefer HG, Schmeer N: Q fever in Europe: Current Aspects in Aetiology, Epidemiology, Human Infection, Diagnosis and Therapy. 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