{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:03:47Z","timestamp":1788793427198,"version":"build-2803163510"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Although the coexistence of bacterial meningitis and arthritis has been noted in several studies, it remains unclear how often both conditions occur simultaneously.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We evaluated the presence of arthritis in a prospective nationwide cohort of 696 episodes of community-acquired bacterial meningitis, confirmed by culture of cerebrospinal fluid, which occurred in patients aged &gt;16 years. The diagnosis of arthritis was based upon the judgment of the treating physician. To identify differences between groups Fisher exact statistics and the Mann-Whitney U test were used.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Arthritis was recorded in 48 of 696 (7%) episodes of community-acquired bacterial meningitis in adults. Joint-fluid aspirations were performed in 23 of 48 patients (48%) and joint-fluid cultures yielded bacteria in 6 of 23 patients (26%). Arthritis occurred most frequently in patients with meningococcal meningitis (12%). Of the 48 patients with bacterial meningitis and coexisting arthritis, four died (8%) and 10 (23%) had residual joint symptoms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Arthritis is a common manifestation in patients with community-acquired bacterial meningitis. Functional outcome of arthritis in bacterial meningitis is generally good because meningococcal arthritis is usually immune-mediated, and pneumococcal arthritis is generally less deforming than staphylococcal arthritis. Nevertheless, additional therapeutic measures should be considered if clinical course is complicated by arthritis. In patients with infectious arthritis prolonged antibiotic therapy is mandatory.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-6-64","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T13:32:43Z","timestamp":1144330363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Arthritis in adults with community-acquired bacterial meningitis: a prospective cohort study"],"prefix":"10.1186","volume":"6","author":[{"given":"Martijn","family":"Weisfelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederik","family":"van de Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lodewijk","family":"Spanjaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"de Gans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"328_CR1","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1001\/archneur.1993.00540060015010","volume":"50","author":"HW Pfister","year":"1993","unstructured":"Pfister HW, Feiden W, Einhaupl KM: Spectrum of complications during bacterial meningitis in adults: Results of a prospective clinical study. Arch Neurol. 1993, 50: 575-581.","journal-title":"Arch Neurol"},{"key":"328_CR2","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1086\/345954","volume":"36","author":"JJ Ross","year":"2003","unstructured":"Ross JJ, Saltzman CL, Carling P, Shapiro DS: Pneumococcal septic arthritis: review of 190 cases. Clin Infect Dis. 2003, 36: 319-327. 10.1086\/345954.","journal-title":"Clin Infect Dis"},{"key":"328_CR3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/00006454-199703000-00018","volume":"16","author":"M Dillon","year":"1997","unstructured":"Dillon M, Nourse C, Dowling F, Deasy P, Butler K: Primary meningococcal arthritis. Pediatr Infect Dis J. 1997, 16: 331-332. 10.1097\/00006454-199703000-00018.","journal-title":"Pediatr Infect Dis J"},{"key":"328_CR4","first-page":"424","volume":"140","author":"S Likitnukul","year":"1986","unstructured":"Likitnukul S, McCracken GH, Nelson JD: Arthritis in children with bacterial meningitis. 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