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This study was to investigate the relationship between tumor necrosis factor (TNF)-<jats:italic>\u03b1<\/jats:italic> gene polymorphisms with the occurrence of SARS-CoV infection and its role in prognosis of patients with lung interstitial fibrosis and femoral head osteonecrosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The association between genetic polymorphisms of <jats:italic>TNF-\u03b1<\/jats:italic> gene and susceptibility to severe acute respiratory syndromes (SARS) was conducted in a hospital-based case-control study including 75 SARS patients, 41 health care workers and 92 healthy controls. Relationships of TNF-\u03b1 gene polymorphisms with interstitial lung fibrosis and femoral head osteonecrosis were carried out in two case-case studies in discharged SARS patients. PCR sequencing based typing (PCR-SBT) method was used to determine the polymorphisms of <jats:italic>TNF-\u03b1<\/jats:italic> gene in locus of the promoter region and univariate logistic analysis was conducted in analyzing the collected data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Compared to TT genotype, the CT genotype at the -204 locus was found associated with a protective effect on SARS with OR(95%<jats:italic>CI<\/jats:italic>) of 0.95(0.90\u20130.99). Also, TT genotype, CT and CC were found associated with a risk effect on femoral head necrosis with ORs(95%<jats:italic>CI<\/jats:italic>) of 5.33(1.39\u201320.45) and 5.67(2.74\u201311.71), respectively and the glucocorticoid adjusted OR of CT was 5.25(95%CI 1.18\u201323.46) and the combined (CT and CC) genotype OR was 6.0 (95%<jats:italic>CI<\/jats:italic> 1.60\u201322.55) at -1031 site of <jats:italic>TNF-\u03b1<\/jats:italic> gene. At the same time, the -863 AC genotype was manifested as another risk effect associated with femoral head necrosis with OR(95%<jats:italic>CI<\/jats:italic>) of 6.42(1.53\u201326.88) and the adjusted OR was 8.40(95%CI 1.76\u201340.02) in cured SARS patients compared to CC genotype.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>SNPs of <jats:italic>TNF-\u03b1<\/jats:italic> gene of promoter region may not associate with SARS-CoV infection. And these SNPs may not affect interstitial lung fibrosis in cured SARS patients. However, the -1031CT\/CC and -863 AC genotypes may be risk factors of femoral head necrosis in discharged SARS patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-8-27","type":"journal-article","created":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T07:13:30Z","timestamp":1204355610000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Roles of TNF-\u03b1 gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control study"],"prefix":"10.1186","volume":"8","author":[{"given":"Shixin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoti","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keju","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuli","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,2,29]]},"reference":[{"key":"618_CR1","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/44853","volume":"401","author":"The MHC sequencing consortium","year":"1999","unstructured":"The MHC sequencing consortium: Complete sequence and gene map of a human major histocompatibility complex. 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