{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:25:10Z","timestamp":1791095110613,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Shigellosis remains considerable public health problem in some developing countries. The nature of\n                      <jats:italic>Shigellae<\/jats:italic>\n                      suggests that they are highly adaptable when placed under selective pressure in a human population. This is demonstrated by variation and fluctuations in serotypes and antimicrobial resistance profile of organisms circulating in differing setting in endemic locations. Antimicrobial resistance in the genus\n                      <jats:italic>Shigella<\/jats:italic>\n                      is a constant threat, with reports of organisms in Asia being resistant to multiple antimicrobials and new generation therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here we compare microbiological, clinical and epidemiological data from patients with shigellosis over three different periods in southern Vietnam spanning14 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our data demonstrates a shift in dominant infecting species (\n                      <jats:italic>S. flexneri<\/jats:italic>\n                      to\n                      <jats:italic>S. sonnei<\/jats:italic>\n                      ) and resistance profile of the organisms circulating in southern Vietnam. We find that there was no significant variation in the syndromes associated with either\n                      <jats:italic>S. sonnei<\/jats:italic>\n                      or\n                      <jats:italic>S. flexneri<\/jats:italic>\n                      , yet the clinical features of the disease are more severe in later observations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings show a change in clinical presentation of shigellosis in this setting, as the disease may be now more pronounced, this is concurrent with a change in antimicrobial resistance profile. These data highlight the socio-economic development of southern Vietnam and should guide future vaccine development and deployment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Current Controlled Trials ISRCTN55945881<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2334-9-204","type":"journal-article","created":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T02:17:43Z","timestamp":1260843463000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["A changing picture of shigellosis in southern Vietnam: shifting species dominance, antimicrobial susceptibility and clinical presentation"],"prefix":"10.1186","volume":"9","author":[{"given":"Ha","family":"Vinh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Khanh","family":"Nhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Vu Thieu","family":"Nga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham Thanh","family":"Duy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James I","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Van Minh","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej F","family":"Boni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Vu Tra","family":"My","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Thi Thu","family":"Nga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham","family":"Van Minh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao Thu","family":"Thuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"To Song","family":"Diep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi","family":"Phuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Thu","family":"Chinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Thi","family":"Loan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Hong","family":"Tham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Ngoc","family":"Lanh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bui Li","family":"Mong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vo Thi Cuc","family":"Anh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Van Be","family":"Bay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Van Vinh","family":"Chau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Farrar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,15]]},"reference":[{"issue":"4","key":"969_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1017\/S095026880800040X","volume":"136","author":"MA Miller","year":"2008","unstructured":"Miller MA, Sentz J, Rabaa MA, Mintz ED: Global epidemiology of infections due to Shigella, Salmonella serotype Typhi, and enterotoxigenic Escherichia coli. Epidemiol Infect. 2008, 136 (4): 433-435. 10.1017\/S095026880800040X.","journal-title":"Epidemiol Infect"},{"issue":"5","key":"969_CR2","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1017\/S0950268807009351","volume":"136","author":"PK Ram","year":"2008","unstructured":"Ram PK, Crump JA, Gupta SK, Miller MA, Mintz ED: Part II. Analysis of data gaps pertaining to Shigella infections in low and medium human development index countries, 1984-2005. Epidemiol Infect. 2008, 136 (5): 577-603. 10.1017\/S0950268807009351.","journal-title":"Epidemiol Infect"},{"issue":"8","key":"969_CR3","first-page":"651","volume":"77","author":"KL Kotloff","year":"1999","unstructured":"Kotloff KL, Winickoff JP, Ivanoff B, Clemens JD, Swerdlow DL, Sansonetti PJ, Adak GK, Levine MM: Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull World Health Organ. 1999, 77 (8): 651-666.","journal-title":"Bull World Health Organ"},{"issue":"22","key":"969_CR4","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1056\/NEJMra020201","volume":"347","author":"CM Parry","year":"2002","unstructured":"Parry CM, Hien TT, Dougan G, White NJ, Farrar JJ: Typhoid fever. N Engl J Med. 2002, 347 (22): 1770-1782. 10.1056\/NEJMra020201.","journal-title":"N Engl J Med"},{"issue":"10","key":"969_CR5","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1086\/386326","volume":"38","author":"A Gupta","year":"2004","unstructured":"Gupta A, Polyak CS, Bishop RD, Sobel J, Mintz ED: Laboratory-confirmed shigellosis in the United States, 1989-2002: epidemiologic trends and patterns. Clin Infect Dis. 2004, 38 (10): 1372-1377. 10.1086\/386326.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"969_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s100960050439","volume":"19","author":"A Mates","year":"2000","unstructured":"Mates A, Eyny D, Philo S: Antimicrobial resistance trends in Shigella serogroups isolated in Israel, 1990-1995. Eur J Clin Microbiol Infect Dis. 2000, 19 (2): 108-111. 10.1007\/s100960050439.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"969_CR7","volume-title":"The World Health Organization, Department of Vaccines and Biologicals","author":"J Clemens","year":"1999","unstructured":"Clemens J, Kotloff K, Bradford K: Generic protocol to estimate the burden of Shigella diarrhoea and dysenteric mortality. The World Health Organization, Department of Vaccines and Biologicals. 1999"},{"key":"969_CR8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/978-1-4757-4580-1_11","volume":"33","author":"K Niebuhr","year":"2000","unstructured":"Niebuhr K, Sansonetti PJ: Invasion of epithelial cells by bacterial pathogens the paradigm of Shigella. Subcell Biochem. 2000, 33: 251-287.","journal-title":"Subcell Biochem"},{"issue":"1397","key":"969_CR9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1098\/rstb.2000.0599","volume":"355","author":"DJ Philpott","year":"2000","unstructured":"Philpott DJ, Edgeworth JD, Sansonetti PJ: The pathogenesis of Shigella flexneri infection: lessons from in vitro and in vivo studies. Philos Trans R Soc Lond B Biol Sci. 2000, 355 (1397): 575-586. 10.1098\/rstb.2000.0599.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"9","key":"969_CR10","doi-asserted-by":"publisher","first-page":"e353","DOI":"10.1371\/journal.pmed.0030353","volume":"3","author":"L von Seidlein","year":"2006","unstructured":"von Seidlein L, Kim DR, Ali M, Lee H, Wang X, Thiem VD, Canh DG, Chaicumpa W, Agtini MD, Hossain A, et al: A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology. PLoS Med. 2006, 3 (9): e353-10.1371\/journal.pmed.0030353.","journal-title":"PLoS Med"},{"issue":"5","key":"969_CR11","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1111\/j.1365-2958.2006.05172.x","volume":"60","author":"T Wirth","year":"2006","unstructured":"Wirth T, Falush D, Lan R, Colles F, Mensa P, Wieler LH, Karch H, Reeves PR, Maiden MC, Ochman H, et al: Sex and virulence in Escherichia coli: an evolutionary perspective. Mol Microbiol. 2006, 60 (5): 1136-1151. 10.1111\/j.1365-2958.2006.05172.x.","journal-title":"Mol Microbiol"},{"issue":"8","key":"969_CR12","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1128\/JCM.00310-06","volume":"44","author":"S Farshad","year":"2006","unstructured":"Farshad S, Sheikhi R, Japoni A, Basiri E, Alborzi A: Characterization of Shigella strains in Iran by plasmid profile analysis and PCR amplification of ipa genes. J Clin Microbiol. 2006, 44 (8): 2879-2883. 10.1128\/JCM.00310-06.","journal-title":"J Clin Microbiol"},{"issue":"7","key":"969_CR13","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1073\/pnas.95.7.3943","volume":"95","author":"AT Maurelli","year":"1998","unstructured":"Maurelli AT, Fernandez RE, Bloch CA, Rode CK, Fasano A: \"Black holes\" and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Proc Natl Acad Sci USA. 1998, 95 (7): 3943-3948. 10.1073\/pnas.95.7.3943.","journal-title":"Proc Natl Acad Sci USA"},{"key":"969_CR14","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/1471-2164-7-173","volume":"7","author":"H Nie","year":"2006","unstructured":"Nie H, Yang F, Zhang X, Yang J, Chen L, Wang J, Xiong Z, Peng J, Sun L, Dong J, et al: Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a. BMC Genomics. 2006, 7: 173-10.1186\/1471-2164-7-173.","journal-title":"BMC Genomics"},{"issue":"10","key":"969_CR15","first-page":"739","volume":"83","author":"P Chompook","year":"2005","unstructured":"Chompook P, Samosornsuk S, von Seidlein L, Jitsanguansuk S, Sirima N, Sudjai S, Mangjit P, Kim DR, Wheeler JG, Todd J, et al: Estimating the burden of shigellosis in Thailand: 36-month population-based surveillance study. Bull World Health Organ. 2005, 83 (10): 739-746.","journal-title":"Bull World Health Organ"},{"issue":"3","key":"969_CR16","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0035-9203(00)90343-2","volume":"94","author":"H Vinh","year":"2000","unstructured":"Vinh H, Wain J, Chinh MT, Tam CT, Trang PT, Nga D, Echeverria P, Diep TS, White NJ, Parry CM: Treatment of bacillary dysentery in Vietnamese children: two doses of ofloxacin versus 5-days nalidixic acid. Trans R Soc Trop Med Hyg. 2000, 94 (3): 323-326. 10.1016\/S0035-9203(00)90343-2.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"969_CR17","volume-title":"Performance Standards For Antimicrobial Susceptibility Testing; Seventeenth Informational Supplement","author":"CLSI","year":"2007","unstructured":"CLSI: Performance Standards For Antimicrobial Susceptibility Testing; Seventeenth Informational Supplement. 2007, 27 (1):"},{"key":"969_CR18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/1471-2334-5-89","volume":"5","author":"MD Agtini","year":"2005","unstructured":"Agtini MD, Soeharno R, Lesmana M, Punjabi NH, Simanjuntak C, Wangsasaputra F, Nurdin D, Pulungsih SP, Rofiq A, Santoso H, et al: The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance. BMC Infect Dis. 2005, 5: 89-10.1186\/1471-2334-5-89.","journal-title":"BMC Infect Dis"},{"issue":"2","key":"969_CR19","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4269\/ajtmh.2005.73.416","volume":"73","author":"XY Wang","year":"2005","unstructured":"Wang XY, Du L, Von Seidlein L, Xu ZY, Zhang YL, Hao ZY, Han OP, Ma JC, Lee HJ, Ali M, et al: Occurrence of shigellosis in the young and elderly in rural China: results of a 12-month population-based surveillance study. Am J Trop Med Hyg. 2005, 73 (2): 416-422.","journal-title":"Am J Trop Med Hyg"},{"issue":"Pt 8","key":"969_CR20","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1099\/jmm.0.47093-0","volume":"56","author":"BT Hien","year":"2007","unstructured":"Hien BT, Trang do T, Scheutz F, Cam PD, Molbak K, Dalsgaard A: Diarrhoeagenic Escherichia coli and other causes of childhood diarrhoea: a case-control study in children living in a wastewater-use area in Hanoi, Vietnam. J Med Microbiol. 2007, 56 (Pt 8): 1086-1096. 10.1099\/jmm.0.47093-0.","journal-title":"J Med Microbiol"},{"issue":"4","key":"969_CR21","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.healthplace.2007.12.003","volume":"14","author":"DR Kim","year":"2008","unstructured":"Kim DR, Ali M, Thiem VD, Park JK, von Seidlein L, Clemens J: Geographic analysis of shigellosis in Vietnam. Health Place. 2008, 14 (4): 755-767. 10.1016\/j.healthplace.2007.12.003.","journal-title":"Health Place"},{"issue":"Pt 2","key":"969_CR22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1099\/jmm.0.002949-0","volume":"58","author":"H Vinh","year":"2009","unstructured":"Vinh H, Baker S, Campbell J, Hoang NV, Loan HT, Chinh MT, Anh VT, Diep TS, Phuong LT, Schultsz C, et al: Rapid emergence of third generation cephalosporin resistant Shigella spp. in Southern Vietnam. J Med Microbiol. 2009, 58 (Pt 2): 281-283. 10.1099\/jmm.0.002949-0.","journal-title":"J Med Microbiol"},{"key":"969_CR23","unstructured":"Guidelines for the control of shigellosis, including epidemics due to Shigella dysenteriae type 1, from the World Health Organization workshop at the Centre for Health and Population Research Dhaka, Bangladesh, 16-18 February 2004. [http:\/\/whqlibdoc.who.int\/publications\/2005\/9241592330.pdf]"},{"issue":"7","key":"969_CR24","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1128\/IAI.67.7.3437-3443.1999","volume":"67","author":"TS Coster","year":"1999","unstructured":"Coster TS, Hoge CW, VanDeVerg LL, Hartman AB, Oaks EV, Venkatesan MM, Cohen D, Robin G, Fontaine-Thompson A, Sansonetti PJ, et al: Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602. Infect Immun. 1999, 67 (7): 3437-3443.","journal-title":"Infect Immun"},{"issue":"2","key":"969_CR25","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1128\/IAI.72.2.923-930.2004","volume":"72","author":"DE Katz","year":"2004","unstructured":"Katz DE, Coster TS, Wolf MK, Trespalacios FC, Cohen D, Robins G, Hartman AB, Venkatesan MM, Taylor DN, Hale TL: Two studies evaluating the safety and immunogenicity of a live, attenuated Shigella flexneri 2a vaccine (SC602) and excretion of vaccine organisms in North American volunteers. Infect Immun. 2004, 72 (2): 923-930. 10.1128\/IAI.72.2.923-930.2004.","journal-title":"Infect Immun"},{"issue":"5","key":"969_CR26","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/0264-410X(94)00011-B","volume":"13","author":"KL Kotloff","year":"1995","unstructured":"Kotloff KL, Losonsky GA, Nataro JP, Wasserman SS, Hale TL, Taylor DN, Newland JW, Sadoff JC, Formal SB, Levine MM: Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2. Vaccine. 1995, 13 (5): 495-502. 10.1016\/0264-410X(94)00011-B.","journal-title":"Vaccine"},{"issue":"3","key":"969_CR27","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1128\/IAI.68.3.1034-1039.2000","volume":"68","author":"KL Kotloff","year":"1207","unstructured":"Kotloff KL, Noriega FR, Samandari T, Sztein MB, Losonsky GA, Nataro JP, Picking WD, Barry EM, Levine MM: Shigella flexneri 2a strain CVD with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humans. Infect Immun. 1207, 68 (3): 1034-1039. 10.1128\/IAI.68.3.1034-1039.2000.","journal-title":"Infect Immun"},{"issue":"2","key":"969_CR28","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1017\/S0950268802007240","volume":"129","author":"S Dutta","year":"2002","unstructured":"Dutta S, Rajendran K, Roy S, Chatterjee A, Dutta P, Nair GB, Bhattacharya SK, Yoshida SI: Shifting serotypes, plasmid profile analysis and antimicrobial resistance pattern of shigellae strains isolated from Kolkata, India during 1995-2000. Epidemiol Infect. 2002, 129 (2): 235-243. 10.1017\/S0950268802007240.","journal-title":"Epidemiol Infect"},{"issue":"16","key":"969_CR29","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1016\/0264-410X(95)00102-7","volume":"13","author":"KL Kotloff","year":"1995","unstructured":"Kotloff KL, Nataro JP, Losonsky GA, Wasserman SS, Hale TL, Taylor DN, Sadoff JC, Levine MM: A modified Shigella volunteer challenge model in which the inoculum is administered with bicarbonate buffer: clinical experience and implications for Shigella infectivity. Vaccine. 1995, 13 (16): 1488-1494. 10.1016\/0264-410X(95)00102-7.","journal-title":"Vaccine"},{"issue":"6","key":"969_CR30","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/oxfordjournals.aje.a116134","volume":"134","author":"C Ferreccio","year":"1991","unstructured":"Ferreccio C, Prado V, Ojeda A, Cayyazo M, Abrego P, Guers L, Levine MM: Epidemiologic patterns of acute diarrhea and endemic Shigella infections in children in a poor periurban setting in Santiago, Chile. Am J Epidemiol. 1991, 134 (6): 614-627.","journal-title":"Am J Epidemiol"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-9-204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2334-9-204\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-9-204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2334-9-204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T04:24:16Z","timestamp":1630470256000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/1471-2334-9-204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["969"],"URL":"https:\/\/doi.org\/10.1186\/1471-2334-9-204","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"6 August 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"204"}}