{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:06:45Z","timestamp":1774120005720,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Peritonitis continues to be the most frequent cause of peritoneal dialysis (PD) failure, with an important impact on patient mortality. Gram-positive cocci such as <jats:italic>Staphylococcus epidermidis<\/jats:italic>, other coagulase-negative staphylococci (CoNS), and <jats:italic>Staphylococcus aureus<\/jats:italic> are the most frequent etiological agents of PD-associated peritonitis worldwide. The objective of the present study was to compare peritonitis caused by <jats:italic>S. aureus<\/jats:italic> and CoNS and to evaluate the factors influencing outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Records of 86 new episodes of staphylococcal peritonitis that occurred between 1996 and 2000 in the Dialysis unit of a single university hospital were studied (35 due to <jats:italic>S. aureus<\/jats:italic>, 24 to <jats:italic>S. epidermidis<\/jats:italic> and 27 to other CoNS). The production of slime, lipase, lecithinase, nuclease (DNAse), thermonuclease (TNAse), \u03b1- and \u03b2-hemolysin, enterotoxins (SEA, SEB, SEC, SED) and toxic shock syndrome toxin-1 (TSST-1) was studied in <jats:italic>S. aureus<\/jats:italic> and CoNS. Antimicrobial susceptibility was evaluated based on the minimal inhibitory concentration determined by the E-test. Outcome predictors were evaluated by two logistic regression models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The oxacillin susceptibility rate was 85.7% for <jats:italic>S. aureus<\/jats:italic>, 41.6% for <jats:italic>S. epidermidis<\/jats:italic>, and 51.8% for other CoNS (p = 0.001). Production of toxins and enzymes, except for enterotoxin A and \u03b1-hemolysin, was associated with <jats:italic>S. aureus<\/jats:italic> episodes (p &lt; 0.001), whereas slime production was positive in 23.5% of CoNS and 8.6% of <jats:italic>S. aureus<\/jats:italic> strains (p = 0.0047). The first model did not include enzymes and toxins due to their association with <jats:italic>S. aureus<\/jats:italic>. The odds of resolution were 9.5 times higher for <jats:italic>S. epidermidis<\/jats:italic> than for <jats:italic>S. aureus<\/jats:italic> (p = 0.02) episodes, and were similar for <jats:italic>S. epidermidis<\/jats:italic> and other CoNS (p = 0.8). The resolution odds were 68 times higher for non-slime producers (p = 0.001) and were not influenced by oxacillin resistance among vancomycin-treated cases (p = 0.89). In the second model, the resolution rate was similar for <jats:italic>S. aureus<\/jats:italic> and <jats:italic>S. epidermidis<\/jats:italic> (p = 0.70), and slime (p = 0.001) and \u03b1-hemolysin (p = 0.04) production were independent predictors of non-resolution.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Bacterial species and virulence factors rather than antibiotic resistance influence the outcome of staphylococcal peritonitis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2334-9-212","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T19:15:13Z","timestamp":1261509313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The role of virulence factors in the outcome of staphylococcal peritonitis in CAPD patients"],"prefix":"10.1186","volume":"9","author":[{"given":"Pasqual","family":"Barretti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto C","family":"Montelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson EN","family":"Batalha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline CT","family":"Caramori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Lourdes RS","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"977_CR1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/089686080902900314","volume":"29","author":"A Davenport","year":"2009","unstructured":"Davenport A: Peritonitis remains the major clinical complication of peritoneal dialysis: The London, UK, Peritonitis Audit 2002-2003. 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