{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T21:28:27Z","timestamp":1763155707541},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,1,3]],"date-time":"2011-01-03T00:00:00Z","timestamp":1294012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1186\/1471-2342-11-1","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T13:42:53Z","timestamp":1362490973000},"source":"Crossref","is-referenced-by-count":31,"title":["(R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus"],"prefix":"10.1186","volume":"11","author":[{"given":"Stina","family":"Syv\u00e4nen","sequence":"first","affiliation":[]},{"given":"Gert","family":"Luurtsema","sequence":"additional","affiliation":[]},{"given":"Carla FM","family":"Molthoff","sequence":"additional","affiliation":[]},{"given":"Albert D","family":"Windhorst","sequence":"additional","affiliation":[]},{"given":"Marc C","family":"Huisman","sequence":"additional","affiliation":[]},{"given":"Adriaan A","family":"Lammertsma","sequence":"additional","affiliation":[]},{"given":"Rob A","family":"Voskuyl","sequence":"additional","affiliation":[]},{"given":"Elizabeth C","family":"de Lange","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2011,1,3]]},"reference":[{"issue":"6","key":"105_CR1","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/j.1528-1167.2005.54904.x","volume":"46","author":"D Schmidt","year":"2005","unstructured":"Schmidt D, L\u00f6scher W: Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia. 2005, 46 (6): 858-877. 10.1111\/j.1528-1167.2005.54904.x.","journal-title":"Epilepsia"},{"issue":"2-3","key":"105_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0920-1211(98)00106-5","volume":"34","author":"G Regesta","year":"1999","unstructured":"Regesta G, Tanganelli P: Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res. 1999, 34 (2-3): 109-122. 10.1016\/S0920-1211(98)00106-5.","journal-title":"Epilepsy Res"},{"issue":"2","key":"105_CR3","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1073\/pnas.86.2.695","volume":"86","author":"C Cordon-Cardo","year":"1989","unstructured":"Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR: Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA. 1989, 86 (2): 695-698. 10.1073\/pnas.86.2.695.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"105_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(02)00169-2","volume":"55","author":"AH Schinkel","year":"2003","unstructured":"Schinkel AH, Jonker JW: Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev. 2003, 55 (1): 3-29. 10.1016\/S0169-409X(02)00169-2.","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"105_CR5","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.nbd.2006.06.014","volume":"24","author":"C Brandt","year":"2006","unstructured":"Brandt C, Bethmann K, Gastens AM, Loscher W: The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy. Neurobiol Dis. 2006, 24 (1): 202-211. 10.1016\/j.nbd.2006.06.014.","journal-title":"Neurobiol Dis"},{"issue":"2","key":"105_CR6","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.neuropharm.2009.09.012","volume":"58","author":"EA van Vliet","year":"2009","unstructured":"van Vliet EA, Zibell G, Pekcec A, Schlichtiger J, Edelbroek PM, Holtman L, Aronica E, Gorter JA, Potschka H: COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. Neuropharmacology. 2009, 58 (2): 404-412. 10.1016\/j.neuropharm.2009.09.012.","journal-title":"Neuropharmacology"},{"issue":"14","key":"105_CR7","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1523\/JNEUROSCI.22-14-05833.2002","volume":"22","author":"M Rizzi","year":"2002","unstructured":"Rizzi M, Caccia S, Guiso G, Richichi C, Gorter JA, Aronica E, Aliprandi M, Bagnati R, Fanelli R, D'Incalci M, et al: Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. J Neurosci. 2002, 22 (14): 5833-5839.","journal-title":"J Neurosci"},{"issue":"2","key":"105_CR8","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.neulet.2006.11.075","volume":"413","author":"C Hocht","year":"2007","unstructured":"Hocht C, Lazarowski A, Gonzalez NN, Auzmendi J, Opezzo JA, Bramuglia GF, Taira CA, Girardi E: Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model. Neurosci Lett. 2007, 413 (2): 168-172. 10.1016\/j.neulet.2006.11.075. Epub 2007 Jan 2008","journal-title":"Neurosci Lett"},{"issue":"1","key":"105_CR9","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.neulet.2009.01.079","volume":"453","author":"C Hocht","year":"2009","unstructured":"Hocht C, Lazarowski A, Gonzalez NN, Mayer MA, Opezzo JA, Taira CA, Girardi E: Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. Neurosci Lett. 2009, 453 (1): 54-57. 10.1016\/j.neulet.2009.01.079. Epub 2009 Feb 2004","journal-title":"Neurosci Lett"},{"issue":"Pt 1","key":"105_CR10","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/brain\/awf002","volume":"125","author":"SM Sisodiya","year":"2002","unstructured":"Sisodiya SM, Lin WR, Harding BN, Squier MV, Thom M: Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain. 2002, 125 (Pt 1): 22-31. 10.1093\/brain\/awf002.","journal-title":"Brain"},{"issue":"1","key":"105_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1528-1157.1995.tb01657.x","volume":"36","author":"DM Tishler","year":"1995","unstructured":"Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C: MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia. 1995, 36 (1): 1-6. 10.1111\/j.1528-1157.1995.tb01657.x.","journal-title":"Epilepsia"},{"issue":"12","key":"105_CR12","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1046\/j.1528-1157.2001.12301.x","volume":"42","author":"SM Dombrowski","year":"2001","unstructured":"Dombrowski SM, Desai SY, Marroni M, Cucullo L, Goodrich K, Bingaman W, Mayberg MR, Bengez L, Janigro D: Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia. 2001, 42 (12): 1501-1506. 10.1046\/j.1528-1157.2001.12301.x.","journal-title":"Epilepsia"},{"issue":"4","key":"105_CR13","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/j.1528-1167.2006.00496.x","volume":"47","author":"EA van Vliet","year":"2006","unstructured":"van Vliet EA, van Schaik R, Edelbroek PM, Redeker S, Aronica E, Wadman WJ, Marchi N, Vezzani A, Gorter JA: Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia. 2006, 47 (4): 672-680. 10.1111\/j.1528-1167.2006.00496.x.","journal-title":"Epilepsia"},{"issue":"1","key":"105_CR14","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.pneurobio.2005.04.006","volume":"76","author":"W L\u00f6scher","year":"2005","unstructured":"L\u00f6scher W, Potschka H: Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol. 2005, 76 (1): 22-76.","journal-title":"Prog Neurobiol"},{"key":"105_CR15","first-page":"3","volume":"3","author":"C Luna-Tortos","year":"2009","unstructured":"Luna-Tortos C, Rambeck B, Jurgens UH, Loscher W: The Antiepileptic Drug Topiramate is a Substrate for Human P-glycoprotein but Not Multidrug Resistance Proteins. Pharm Res. 2009, 3: 3-","journal-title":"Pharm Res"},{"issue":"16","key":"105_CR16","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1097\/00001756-199911080-00032","volume":"10","author":"SM Sisodiya","year":"1999","unstructured":"Sisodiya SM, Heffernan J, Squier MV: Over-expression of P-glycoprotein in malformations of cortical development. Neuroreport. 1999, 10 (16): 3437-3441. 10.1097\/00001756-199911080-00032.","journal-title":"Neuroreport"},{"issue":"1","key":"105_CR17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1124\/jpet.301.1.7","volume":"301","author":"W L\u00f6scher","year":"2002","unstructured":"L\u00f6scher W, Potschka H: Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther. 2002, 301 (1): 7-14.","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"105_CR18","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1124\/mol.108.046680","volume":"73","author":"RW Robey","year":"2008","unstructured":"Robey RW, Lazarowski A, Bates SE: P-glycoprotein--a clinical target in drug-refractory epilepsy?. Mol Pharmacol. 2008, 73 (5): 1343-1346. 10.1124\/mol.108.046680.","journal-title":"Mol Pharmacol"},{"issue":"2-3","key":"105_CR19","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.eplepsyres.2008.10.010","volume":"83","author":"A Pekcec","year":"2009","unstructured":"Pekcec A, Unkruer B, Stein V, Bankstahl JP, Soerensen J, Tipold A, Baumgartner W, Potschka H: Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus. Epilepsy Res. 2009, 83 (2-3): 144-151. 10.1016\/j.eplepsyres.2008.10.010.","journal-title":"Epilepsy Res"},{"issue":"1","key":"105_CR20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.eplepsyres.2008.07.007","volume":"82","author":"JP Bankstahl","year":"2008","unstructured":"Bankstahl JP, L\u00f6scher W: Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus. Epilepsy Res. 2008, 82 (1): 70-85. 10.1016\/j.eplepsyres.2008.07.007.","journal-title":"Epilepsy Res"},{"key":"105_CR21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1535-7511.2005.05311.x","volume":"5","author":"W L\u00f6scher","year":"2005","unstructured":"L\u00f6scher W: How to explain multidrug resistance in epilepsy?. Epilepsy Curr. 2005, 5: 107-112.","journal-title":"Epilepsy Curr"},{"issue":"12","key":"105_CR22","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1111\/j.1528-1167.2007.01260_3.x","volume":"48","author":"GD Anderson","year":"2007","unstructured":"Anderson GD, Shen DD: Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?. Epilepsia. 2007, 48 (12): 2372-2374. 10.1111\/j.1528-1167.2007.01260_3.x.","journal-title":"Epilepsia"},{"issue":"1","key":"105_CR23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0920-1211(98)00017-5","volume":"31","author":"JL Hellier","year":"1998","unstructured":"Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE: Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res. 1998, 31 (1): 73-84. 10.1016\/S0920-1211(98)00017-5.","journal-title":"Epilepsy Res"},{"issue":"2-3","key":"105_CR24","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.eplepsyres.2004.06.005","volume":"60","author":"E van Vliet","year":"2004","unstructured":"van Vliet E, Aronica E, Redeker S, Marchi N, Rizzi M, Vezzani A, Gorter J: Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. Epilepsy Res. 2004, 60 (2-3): 203-213. 10.1016\/j.eplepsyres.2004.06.005.","journal-title":"Epilepsy Res"},{"issue":"3","key":"105_CR25","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1016\/S1053-8119(03)00405-1","volume":"20","author":"J Bart","year":"2003","unstructured":"Bart J, Willemsen AT, Groen HJ, van der Graaf WT, Wegman TD, Vaalburg W, de Vries EG, Hendrikse NH: Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET. Neuroimage. 2003, 20 (3): 1775-1782. 10.1016\/S1053-8119(03)00405-1.","journal-title":"Neuroimage"},{"issue":"8","key":"105_CR26","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.2967\/jnumed.108.051235","volume":"49","author":"JP Bankstahl","year":"2008","unstructured":"Bankstahl JP, Kuntner C, Abrahim A, Karch R, Stanek J, Wanek T, Wadsak W, Kletter K, Muller M, L\u00f6scher W, et al: Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. J Nucl Med. 2008, 49 (8): 1328-1335. 10.2967\/jnumed.108.051235.","journal-title":"J Nucl Med"},{"issue":"10","key":"105_CR27","first-page":"2411","volume":"59","author":"NH Hendrikse","year":"1999","unstructured":"Hendrikse NH, de Vries EG, Eriks-Fluks L, van der Graaf WT, Hospers GA, Willemsen AT, Vaalburg W, Franssen EJ: A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier. Cancer Res. 1999, 59 (10): 2411-2416.","journal-title":"Cancer Res"},{"issue":"3","key":"105_CR28","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.neuroimage.2006.05.047","volume":"32","author":"S Syv\u00e4nen","year":"2006","unstructured":"Syv\u00e4nen S, Blomquist G, Sprycha M, H\u00f6glund AU, Roman M, Eriksson O, Hammarlund-Udenaes M, L\u00e5ngstr\u00f6m B, Bergstr\u00f6m M: Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET. Neuroimage. 2006, 32 (3): 1134-1141.","journal-title":"Neuroimage"},{"issue":"6","key":"105_CR29","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.clpt.2005.01.022","volume":"77","author":"L Sasongko","year":"2005","unstructured":"Sasongko L, Link JM, Muzi M, Mankoff DA, Yang X, Collier AC, Shoner SC, Unadkat JD: Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography. Clin Pharmacol Ther. 2005, 77 (6): 503-514. 10.1016\/j.clpt.2005.01.022.","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"105_CR30","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1124\/jpet.105.088328","volume":"316","author":"YJ Lee","year":"2006","unstructured":"Lee YJ, Maeda J, Kusuhara H, Okauchi T, Inaji M, Nagai Y, Obayashi S, Nakao R, Suzuki K, Sugiyama Y, et al: In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil. J Pharmacol Exp Ther. 2006, 316 (2): 647-653. 10.1124\/jpet.105.088328.","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"105_CR31","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.clpt.2006.02.004","volume":"79","author":"R Toornvliet","year":"2006","unstructured":"Toornvliet R, van Berckel BN, Luurtsema G, Lubberink M, Geldof AA, Bosch TM, Oerlemans R, Lammertsma AA, Franssen EJ: Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography. Clin Pharmacol Ther. 2006, 79 (6): 540-548. 10.1016\/j.clpt.2006.02.004.","journal-title":"Clin Pharmacol Ther"},{"issue":"9","key":"105_CR32","first-page":"1531","volume":"47","author":"Y Ikoma","year":"2006","unstructured":"Ikoma Y, Takano A, Ito H, Kusuhara H, Sugiyama Y, Arakawa R, Fukumura T, Nakao R, Suzuki K, Suhara T: Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function. J Nucl Med. 2006, 47 (9): 1531-1537.","journal-title":"J Nucl Med"},{"issue":"2","key":"105_CR33","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/ana.20369","volume":"57","author":"R Kortekaas","year":"2005","unstructured":"Kortekaas R, Leenders KL, van Oostrom JC, Vaalburg W, Bart J, Willemsen AT, Hendrikse NH: Blood-brain barrier dysfunction in parkinsonian midbrain in vivo. Ann Neurol. 2005, 57 (2): 176-179. 10.1002\/ana.20369.","journal-title":"Ann Neurol"},{"issue":"9","key":"105_CR34","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1111\/j.1528-1167.2007.01116.x","volume":"48","author":"O Langer","year":"2007","unstructured":"Langer O, Bauer M, Hammers A, Karch R, Pataraia E, Koepp MJ, Abrahim A, Luurtsema G, Brunner M, Sunder-Plassmann R, et al: Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia. 2007, 48 (9): 1774-1784. 10.1111\/j.1528-1167.2007.01116.x.","journal-title":"Epilepsia"},{"issue":"3","key":"105_CR35","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0013-4694(72)90178-2","volume":"32","author":"R Racine","year":"1972","unstructured":"Racine R, Okujava V, Chipashvili S: Modification of seizure activity by electrical stimulation. 3. Mechanisms. Electroencephalogr Clin Neurophysiol. 1972, 32 (3): 295-299. 10.1016\/0013-4694(72)90178-2.","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"105_CR36","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1002\/jlcr.632","volume":"45","author":"G Luurtsema","year":"2002","unstructured":"Luurtsema G, Windhorst AD, J. MP, Herscheid JDM, Lammertsma AA, Franssen EJ: Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring the P-glycoprotein function with positron emission tomography. J Labelled Compd Radiopharm. 2002, 45: 1199-1207. 10.1002\/jlcr.632.","journal-title":"J Labelled Compd Radiopharm"},{"issue":"5","key":"105_CR37","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1088\/0031-9155\/52\/5\/019","volume":"52","author":"HW de Jong","year":"2007","unstructured":"de Jong HW, van Velden FH, Kloet RW, Buijs FL, Boellaard R, Lammertsma AA: Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner. Phys Med Biol. 2007, 52 (5): 1505-1526. 10.1088\/0031-9155\/52\/5\/019.","journal-title":"Phys Med Biol"},{"issue":"1","key":"105_CR38","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1088\/0031-9155\/53\/1\/007","volume":"53","author":"FH van Velden","year":"2008","unstructured":"van Velden FH, Kloet RW, van Berckel BN, Molthoff CF, de Jong HW, Lammertsma AA, Boellaard R: Impact of attenuation correction strategies on the quantification of High Resolution Research Tomograph PET studies. Phys Med Biol. 2008, 53 (1): 99-118. 10.1088\/0031-9155\/53\/1\/007.","journal-title":"Phys Med Biol"},{"issue":"5","key":"105_CR39","doi-asserted-by":"publisher","first-page":"693","DOI":"10.2967\/jnumed.108.058628","volume":"50","author":"FH van Velden","year":"2009","unstructured":"van Velden FH, Kloet RW, van Berckel BN, Buijs FL, Luurtsema G, Lammertsma AA, Boellaard R: HRRT Versus HR+ Human Brain PET Studies: An Interscanner Test-Retest Study. J Nucl Med. 2009, 50 (5): 693-702. 10.2967\/jnumed.108.058628.","journal-title":"J Nucl Med"},{"issue":"1","key":"105_CR40","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.nucmedbio.2004.06.007","volume":"32","author":"G Luurtsema","year":"2005","unstructured":"Luurtsema G, Molthoff CF, Schuit RC, Windhorst AD, Lammertsma AA, Franssen EJ: Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat. Nucl Med Biol. 2005, 32 (1): 87-93. 10.1016\/j.nucmedbio.2004.06.007.","journal-title":"Nucl Med Biol"},{"issue":"4","key":"105_CR41","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1369\/jhc.4A6451.2005","volume":"53","author":"H Volk","year":"2005","unstructured":"Volk H, Potschka H, Loscher W: Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables. J Histochem Cytochem. 2005, 53 (4): 517-531. 10.1369\/jhc.4A6451.2005.","journal-title":"J Histochem Cytochem"},{"key":"105_CR42","volume-title":"The Rat Brain in stereotaxic coordinates","author":"G Paxinos","year":"1986","unstructured":"Paxinos G, Watson C: The Rat Brain in stereotaxic coordinates. 1986, New York: Academic Press, 2","edition":"2"},{"issue":"7","key":"105_CR43","first-page":"36","volume":"11","author":"MD Abramoff","year":"2004","unstructured":"Abramoff MD, Magelhaes PJ, Ram SJ: Image Processing with ImageJ. Biophotonics International. 2004, 11 (7): 36-42.","journal-title":"Biophotonics International"},{"key":"105_CR44","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1162\/153535003322556877","volume":"2","author":"AM Loening","year":"2003","unstructured":"Loening AM, Gambhir SS: AMIDE: A free software tool for multimodality medical image analysis. Mol Imaging. 2003, 2: 131-137. 10.1162\/153535003322556877.","journal-title":"Mol Imaging"},{"issue":"1 Pt 2","key":"105_CR45","first-page":"H75","volume":"263","author":"MM Todd","year":"1992","unstructured":"Todd MM, Weeks JB, Warner DS: Cerebral blood flow, blood volume, and brain tissue hematocrit during isovolemic hemodilution with hetastarch in rats. Am J Physiol. 1992, 263 (1 Pt 2): H75-82.","journal-title":"Am J Physiol"},{"issue":"2","key":"105_CR46","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/sj.jcbfm.9600349","volume":"27","author":"M Lubberink","year":"2007","unstructured":"Lubberink M, Luurtsema G, van Berckel BN, Boellaard R, Toornvliet R, Windhorst AD, Franssen EJ, Lammertsma AA: Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET. J Cereb Blood Flow Metab. 2007, 27 (2): 424-433. 10.1038\/sj.jcbfm.9600349.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"105_CR47","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/jcbfm.1990.127","volume":"10","author":"J Logan","year":"1990","unstructured":"Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ, MacGregor RR, Hitzemann R, Bendriem B, Gatley SJ, et al: Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab. 1990, 10 (5): 740-747.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"105_CR48","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1097\/00004647-200106000-00002","volume":"21","author":"RN Gunn","year":"2001","unstructured":"Gunn RN, Gunn SR, Cunningham VJ: Positron emission tomography compartmental models. J Cereb Blood Flow Metab. 2001, 21 (6): 635-652. 10.1097\/00004647-200106000-00002.","journal-title":"J Cereb Blood Flow Metab"},{"key":"105_CR49","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","volume":"19","author":"H Akaike","year":"1974","unstructured":"Akaike H: A new look at the statistical model identification. IEEE Trans Autom Control. 1974, 19: 716-723. 10.1109\/TAC.1974.1100705.","journal-title":"IEEE Trans Autom Control"},{"issue":"1","key":"105_CR50","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0169-2607(98)00067-4","volume":"58","author":"EN Jonsson","year":"1999","unstructured":"Jonsson EN, Karlsson MO: Xpose - an S-PLUS based population pharmacokinetic\/pharmacodynamic model building aid for NONMEM. Computer Methods and Programs in Biomedicine. 1999, 58 (1): 51-64. 10.1016\/S0169-2607(98)00067-4.","journal-title":"Computer Methods and Programs in Biomedicine"},{"issue":"3","key":"105_CR51","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.cmpb.2005.02.003","volume":"78","author":"JJ Wilkins","year":"2005","unstructured":"Wilkins JJ: NONMEMory: a run management tool for NONMEM. Comput Methods Programs Biomed. 2005, 78 (3): 259-267. 10.1016\/j.cmpb.2005.02.003.","journal-title":"Comput Methods Programs Biomed"},{"issue":"5","key":"105_CR52","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.neuropharm.2009.01.009","volume":"56","author":"G Zibell","year":"2009","unstructured":"Zibell G, Unkruer B, Pekcec A, Hartz AM, Bauer B, Miller DS, Potschka H: Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. Neuropharmacology. 2009, 56 (5): 849-855. 10.1016\/j.neuropharm.2009.01.009.","journal-title":"Neuropharmacology"},{"issue":"1","key":"105_CR53","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.pharmthera.2009.10.004","volume":"125","author":"H Potschka","year":"2009","unstructured":"Potschka H: Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach. Pharmacol Ther. 2009, 125 (1): 118-127. 10.1016\/j.pharmthera.2009.10.004.","journal-title":"Pharmacol Ther"},{"issue":"3","key":"105_CR54","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.nic.2004.04.011","volume":"14","author":"TR Henry","year":"2004","unstructured":"Henry TR, Votaw JR: The role of positron emission tomography with [18F]fluorodeoxyglucose in the evaluation of the epilepsies. Neuroimaging Clin N Am. 2004, 14 (3): 517-535. 10.1016\/j.nic.2004.04.011. ix","journal-title":"Neuroimaging Clin N Am"},{"issue":"12","key":"105_CR55","doi-asserted-by":"publisher","first-page":"5386","DOI":"10.1002\/jps.21359","volume":"97","author":"S Syv\u00e4nen","year":"2008","unstructured":"Syv\u00e4nen S, Hooker A, Rahman O, Wilking H, Blomquist G, L\u00e5ngstr\u00f6m B, Bergstr\u00f6m M, Hammarlund-Udenaes M: Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier. J Pharm Sci. 2008, 97 (12): 5386-5400.","journal-title":"J Pharm Sci"},{"issue":"16","key":"105_CR56","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1002\/glia.20725","volume":"56","author":"PT Ronaldson","year":"2008","unstructured":"Ronaldson PT, Persidsky Y, Bendayan R: Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection. Glia. 2008, 56 (16): 1711-1735. 10.1002\/glia.20725.","journal-title":"Glia"},{"issue":"19","key":"105_CR57","doi-asserted-by":"publisher","first-page":"6034","DOI":"10.1021\/jm800510m","volume":"51","author":"N Lazarova","year":"2008","unstructured":"Lazarova N, Zoghbi SS, Hong J, Seneca N, Tuan E, Gladding RL, Liow JS, Taku A, Innis RB, Pike VW: Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. J Med Chem. 2008, 51 (19): 6034-6043. 10.1021\/jm800510m.","journal-title":"J Med Chem"},{"issue":"9","key":"105_CR58","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1111\/j.1528-1167.2010.02671.x","volume":"51","author":"H Bartmann","year":"2010","unstructured":"Bartmann H, Fuest C, La Fougere C, Xiong G, Just T, Schlichtiger J, Winter P, Boning G, Wangler B, Pekcec A, et al: Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy. Epilepsia. 2010, 51 (9): 1780-1790. 10.1111\/j.1528-1167.2010.02671.x.","journal-title":"Epilepsia"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2342-11-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2342-11-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2342-11-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2342-11-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T20:31:56Z","timestamp":1548102716000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/1471-2342-11-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,3]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["105"],"URL":"https:\/\/doi.org\/10.1186\/1471-2342-11-1","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,3]]},"article-number":"1"}}