{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:33:29Z","timestamp":1764401609734},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Cardiac lipomatous metaplasia (LM) occurs in patients with chronic ischemic heart disease and heart failure with unclear mechanisms. We studied coronary occlusion\/reperfusion-induced myocardial infarction (MI) in rabbits during a 9-months follow-up using 3.0\u00a0T magnetic resonance scanner, and confirmed the presence of MI in acute phase and LM in chronic phase using histopathology.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>MI was surgically induced in 10 rabbits by 90-min coronary artery occlusion and reperfusion. Forty-eight hours later, multiparametric cardiac magnetic resonance imaging (cMRI) was performed at a 3.0\u00a0T clinical scanner for MI diagnosis and cardiac function analysis. Afterwards, seven rabbits were scarified for histochemical staining with triphenyltetrazolium chloride (TTC), and hematoxylin-eosin (HE), and 3 were scanned with cMRI at 2\u00a0days, 2\u00a0weeks, 2\u00a0months and 9\u00a0months for longitudinal observations of morphological and functional changes, and the fate of the animals. Post-mortem TTC, HE and Masson's trichrome (MTC) were studied for chronic stage of MI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The size of acute MI correlated well between cMRI and TTC staining (r<jats:sup>2<\/jats:sup>=0.83). Global cardiac morphology-function analysis showed significant correlation between increasing acute MI size and decreasing ejection fraction (p&lt;0.001). During 9\u00a0months, cMRI documented evolving morphological and functional changes from acute MI to chronic scar transformation and fat deposition with a definite diagnosis of LM established by histopathology.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Acute MI and chronic LM were induced in rabbits and monitored with 3.0\u00a0T MRI. Studies on this platform may help investigate the mechanisms and therapeutic interventions for LM.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2342-13-18","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T18:49:34Z","timestamp":1372704574000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lipomatous metaplasia identified in rabbits with reperfused myocardial infarction by 3.0\u00a0T magnetic resonance imaging and histopathology"],"prefix":"10.1186","volume":"13","author":[{"given":"Yuanbo","family":"Feng","sequence":"first","affiliation":[]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Yi","family":"Xie","sequence":"additional","affiliation":[]},{"given":"Huaijun","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Marlein Miranda","family":"Cona","sequence":"additional","affiliation":[]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[]},{"given":"Junjie","family":"Li","sequence":"additional","affiliation":[]},{"given":"Jan","family":"Bogaert","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Janssens","sequence":"additional","affiliation":[]},{"given":"Raymond","family":"Oyen","sequence":"additional","affiliation":[]},{"given":"Yicheng","family":"Ni","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,7,1]]},"reference":[{"issue":"2","key":"182_CR1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/eurheartj\/ehm588","volume":"29","author":"H Fonge","year":"2008","unstructured":"Fonge H, Vunckx K, Wang H, Feng Y, Mortelmans L, Nuyts J, et al: Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT. 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