{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:01:42Z","timestamp":1763226102340},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Standard MRI has been used for high-grade gliomas detection, albeit with limited success as it does not provide sufficient specificity and sensitivity to detect complex tumor structure. Therefore targeted contrast agents based on iron oxide, that shorten mostly T2 relaxation time, have been recently applied. However pulse sequences for molecular imaging in animal models of gliomas have not been yet fully studied. The aim of this study was therefore to compare contrast-to-noise ratio (CNR) and explain its origin using spin-echo (SE), gradient echo (GE), GE with flow compensation (GEFC) as well as susceptibility weighted imaging (SWI) in T2 and T2* contrast-enhanced molecular MRI of glioma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A mouse model was used. U87MGdEGFRvIII cells (U87MG), derived from a human tumor, were injected intracerebrally. A 9.4\u00a0T MRI system was used and MR imaging was performed on the 10\u00a0day after the inoculation of the tumor. The CNR was measured prior, 20\u00a0min, 2\u00a0hrs and 24\u00a0hrs post intravenous tail administration of glioma targeted paramagnetic nanoparticles (NPs) using SE, SWI, GE and GEFC pulse sequences.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results showed significant differences in CNR among all pulse sequences prior injection. GEFC provided higher CNR post contrast agent injection when compared to GE and SE. Post injection CNR was the highest with SWI and significantly different from any other pulse sequence.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Molecular MR imaging using targeted contrast agents can enhance the detection of glioma cells at 9.4\u00a0T if the optimal pulse sequence is used. Hence, the use of flow compensated pulse sequences, beside SWI, should to be considered in the molecular imaging studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2342-13-20","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:17:55Z","timestamp":1374193075000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of T2 and T2\n*-weighted MR molecular imaging of a mouse model of glioma"],"prefix":"10.1186","volume":"13","author":[{"given":"Barbara","family":"Blasiak","sequence":"first","affiliation":[]},{"given":"Samuel","family":"Barnes","sequence":"additional","affiliation":[]},{"given":"Tadeusz","family":"Foniok","sequence":"additional","affiliation":[]},{"given":"David","family":"Rushforth","sequence":"additional","affiliation":[]},{"given":"John","family":"Matyas","sequence":"additional","affiliation":[]},{"given":"Dragana","family":"Ponjevic","sequence":"additional","affiliation":[]},{"given":"Wladyslaw P","family":"Weglarz","sequence":"additional","affiliation":[]},{"given":"Randy","family":"Tyson","sequence":"additional","affiliation":[]},{"given":"Umar","family":"Iqbal","sequence":"additional","affiliation":[]},{"given":"Abedelnasser","family":"Abulrob","sequence":"additional","affiliation":[]},{"given":"Garnette R","family":"Sutherland","sequence":"additional","affiliation":[]},{"given":"Andre","family":"Obenaus","sequence":"additional","affiliation":[]},{"given":"Boguslaw","family":"Tomanek","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,7,18]]},"reference":[{"key":"185_CR1","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.mri.2010.03.004","volume":"28","author":"B Blasiak","year":"2010","unstructured":"Blasiak B, Tomanek B, Abulrob A, Iqbal U, Stanimirovic D, Albaghdadi H, Foniok T, Lun X, Forsyth P, Sutherland RG: Detection of T2 changes in an early mouse brain tumor. Magn Res Imag. 2010, 28: 784-789. 10.1016\/j.mri.2010.03.004.","journal-title":"Magn Res Imag"},{"key":"185_CR2","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1093\/jnen\/64.6.479","volume":"64","author":"H Ohagaki","year":"2005","unstructured":"Ohagaki H, Kleihues P: Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol. 2005, 64: 479-489.","journal-title":"J Neuropathol Exp Neurol"},{"key":"185_CR3","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1161\/01.CIR.0000080326.15367.0C","volume":"108","author":"DB Ellegala","year":"2003","unstructured":"Ellegala DB, Leong-Poi H, Carpenter JE, Klibanov AL, Kaul S, Shaffrey ME, Sklenar J, Lindner JR: Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to \u03b1v\u00df3. Circulation. 2003, 108: 336-341. 10.1161\/01.CIR.0000080326.15367.0C.","journal-title":"Circulation"},{"key":"185_CR4","doi-asserted-by":"publisher","first-page":"8600","DOI":"10.1158\/1078-0432.CCR-05-0713","volume":"11","author":"M Aghi","year":"2005","unstructured":"Aghi M, Gaviani P, Henson JW, Batchelor TT, David N, Louis DN, Barker FG: Magnetic resonance imaging characteristics predicts epidermal growth factor receptor amplification status in glioblastomas. Clin Cancer Res. 2005, 11: 8600-8605. 10.1158\/1078-0432.CCR-05-0713.","journal-title":"Clin Cancer Res"},{"key":"185_CR5","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.addr.2009.11.002","volume":"62","author":"O Veish","year":"2010","unstructured":"Veish O, Gunn JW, Zhang M: Design and fabrication of magnetic nanoparticles for targeted drug delivery and therapy. Adv Drug Deliv Rev. 2010, 62: 284-304. 10.1016\/j.addr.2009.11.002.","journal-title":"Adv Drug Deliv Rev"},{"key":"185_CR6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.phrs.2009.12.012","volume":"26","author":"A Figuerola","year":"2010","unstructured":"Figuerola A, Di Corato R, Manna L, Pelligrino T: From iron oxide nanoparticle towards advanced iron-based inorganic materials designed for biomedical applications. Pharmacol Res. 2010, 26: 126-143.","journal-title":"Pharmacol Res"},{"issue":"1","key":"185_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/neuonc\/nor183","volume":"14","author":"B Tomanek","year":"2012","unstructured":"Tomanek B, Iqbal U, Blasiak B, Abulrob A, Albaghdadi H, Matyas JR, Ponjevic D, Sutherland GR: Evaluation of brain tumor vessels specific contrast agents for glioblastoma imaging. Neuro Oncol. 2012, 14 (1): 53-63. 10.1093\/neuonc\/nor183.","journal-title":"Neuro Oncol"},{"key":"185_CR8","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1021\/jz201664h","volume":"3","author":"GK Das","year":"2012","unstructured":"Das GK, Johnson NJJ, Cramen J, Blasiak B, Latta P, Tomanek B, van Veggel FCJM: NaDyF4 nanoparticle as T2 contrast agent for ultra-high field magnetic resonance imaging. J Phys Chem Lett. 2012, 3: 524-529. 10.1021\/jz201664h.","journal-title":"J Phys Chem Lett"},{"issue":"7","key":"185_CR9","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1021\/cm2036844","volume":"24","author":"C Dong","year":"2012","unstructured":"Dong C, Korinek A, Blasiak B, Tomanek B, van Veggel F: Cation exchange: a facile method to make NaYF4:Yb, Tm-NaGdF4 core-shell nanoparticles with a thin, tunable, and uniform shell. Chem Mater. 2012, 24 (7): 1297-1305. 10.1021\/cm2036844.","journal-title":"Chem Mater"},{"key":"185_CR10","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1002\/jmri.21194","volume":"26","author":"LE LaConte","year":"2007","unstructured":"LaConte LE, Nitin N, Zurkiya O, Caruntu D, O\u2019Connor CJ, Hu X, Bao G: Coating thickness of magnetic iron oxide nanoparticles affects R2 relaxivity. J Magn Reson Imag. 2007, 26: 1634-1641. 10.1002\/jmri.21194.","journal-title":"J Magn Reson Imag"},{"key":"185_CR11","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1007\/s003300100908","volume":"11","author":"YX Wang","year":"2001","unstructured":"Wang YX, Hussain SM, Krestin GP: Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur Radiol. 2001, 11: 2319-2331. 10.1007\/s003300100908.","journal-title":"Eur Radiol"},{"key":"185_CR12","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.mri.2005.12.003","volume":"24","author":"G Gambarota","year":"2006","unstructured":"Gambarota G, van Laarhoven HW, Phillipens M, Lok J, van der Kogel A, Punt CJA, Heerschap A: Assessment of absolute blood volume in carcinoma by USPIO contrast-enhanced MRI. Magn Reson Imag. 2006, 24: 279-286. 10.1016\/j.mri.2005.12.003.","journal-title":"Magn Reson Imag"},{"key":"185_CR13","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1148\/radiology.151.2.6709928","volume":"151","author":"VM Runge","year":"1984","unstructured":"Runge VM, Clanton JA, Partian CL, James AE: Respiratory gating in magnetic resonance imaging at 0.5 Tesla. Radiology. 1984, 151: 521-523.","journal-title":"Radiology"},{"key":"185_CR14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0730-725X(86)91046-5","volume":"4","author":"EM Haacke","year":"1986","unstructured":"Haacke EM, Patrick JL: Reducing motion artifacts in two-dimensional Fourier transform imaging. Mag Reson Imaging. 1986, 4: 359-376. 10.1016\/0730-725X(86)91046-5.","journal-title":"Mag Reson Imaging"},{"key":"185_CR15","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1097\/00004728-198507010-00039","volume":"9","author":"DR Bailes","year":"1985","unstructured":"Bailes DR, Gilderdale DJ, Bydder GM, Collins AG, Firmin DN: Respiratory ordered phase encoding (ROPE): a method for reducing motion artefacts in MR imaging. J Comput Assist Tomogr. 1985, 9: 835-838. 10.1097\/00004728-198507010-00039.","journal-title":"J Comput Assist Tomogr"},{"key":"185_CR16","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/mrm.1910140214","volume":"14","author":"RL Ehman","year":"1990","unstructured":"Ehman RL, Felmlee FP: Flow artifact reduction in MRI: a review of the roles of gradients moment nulling and spatial presaturation. Magn Reson Med. 1990, 14: 293-307. 10.1002\/mrm.1910140214.","journal-title":"Magn Reson Med"},{"key":"185_CR17","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.2214\/ajr.148.6.1251","volume":"148","author":"EM Haacke","year":"1987","unstructured":"Haacke EM, Lenz GW: Improving MR image quality in the presence of motion by using rephrasing gradients. AJR Am J Roentgenol. 1987, 148: 1251-1258. 10.2214\/ajr.148.6.1251.","journal-title":"AJR Am J Roentgenol"},{"key":"185_CR18","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/00004728-198705000-00001","volume":"11","author":"PM Pattaney","year":"1987","unstructured":"Pattaney PM, Philips JJ, Chiu LC, Lipcamon JD, Duerk JL, McNally JM, Mohapatra SN: Motion artifacts suppression technique (MAST) for MR imaging. J Comput Assist Tomogr. 1987, 11: 369-377. 10.1097\/00004728-198705000-00001.","journal-title":"J Comput Assist Tomogr"},{"key":"185_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3174\/ajnr.A1400","volume":"30","author":"EM Haacke","year":"2009","unstructured":"Haacke EM, Mittal S, Wue Z, Neelavalli J, Cheng Y-CN: Susceptibility-weighted imaging: technical aspects and clinical applications, part 1. AJNR. 2009, 30: 19-30.","journal-title":"AJNR"},{"key":"185_CR20","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1148\/radiology.204.1.9205259","volume":"204","author":"JR Reichenbach","year":"1997","unstructured":"Reichenbach JR, Venkatesan R, Schillinger DJ, Kido DK, Haacke EM: Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology. 1997, 204: 272-277.","journal-title":"Radiology"},{"key":"185_CR21","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/02681219680000631","volume":"34","author":"MM Nishikawa","year":"1996","unstructured":"Nishikawa MM, Sant\u2019Anna OD, Lazera MS, Wanke B: Use of D-proline assimilation and CGB medium for screening Brazilian Cryptococcus neoformans. J Med Vet Mycol. 1996, 34: 365-366. 10.1080\/02681219680000631.","journal-title":"J Med Vet Mycol"},{"key":"185_CR22","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.addr.2006.09.013","volume":"58","author":"C Corot","year":"2006","unstructured":"Corot C, Robert P, Idee J-M, Port M: Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Deliv Rev. 2006, 58: 1471-1504. 10.1016\/j.addr.2006.09.013.","journal-title":"Adv Drug Deliv Rev"},{"issue":"18","key":"185_CR23","doi-asserted-by":"publisher","first-page":"3995","DOI":"10.1016\/j.biomaterials.2004.10.012","volume":"26","author":"AK Gupta","year":"2005","unstructured":"Gupta AK, Gupta M: Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials. 2005, 26 (18): 3995-4021. 10.1016\/j.biomaterials.2004.10.012.","journal-title":"Biomaterials"},{"key":"185_CR24","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1002\/smll.200801328","volume":"5","author":"E Amstad","year":"2009","unstructured":"Amstad E, Zurcher S, Mashaghi A, Wong JY, Textor M, Reimhult E: Surface functionalization of single superparamagnetic iron oxide nanoparticles for targeted magnetic resonance imaging. Small. 2009, 5: 1334-1342. 10.1002\/smll.200801328.","journal-title":"Small"},{"key":"185_CR25","volume-title":"Single-domain antibody targeted formulations with superparamagnetic nanoparticles for cancer imaging","author":"N Abulrob","year":"2009","unstructured":"Abulrob N, Veres T, Iqbal U, Stanimirovic D, Tomanek B: Single-domain antibody targeted formulations with superparamagnetic nanoparticles for cancer imaging. 2009, US: Provisional Patent, 61\/118,205"},{"key":"185_CR26","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00234-001-0760-0","volume":"44","author":"W Moller-Hartmann","year":"2002","unstructured":"Moller-Hartmann W, Herninghaus S, Krings T, Marquardt G, Lanfermann H, Pilatus U, Zanella FE: Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology. 2002, 44: 371-381. 10.1007\/s00234-001-0760-0.","journal-title":"Neuroradiology"},{"issue":"7","key":"185_CR27","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1073\/pnas.1016409108","volume":"108","author":"N Lee","year":"2011","unstructured":"Lee N, Kim H, Choi SH, Park M, Kim D, Kim HC, Choi Y, Lin S, Kim BH, Jung HS, Kim H, Park KS, Moon WK, Hyeona T: Magnetosome-like ferrimagnetic iron oxide nanocubes for highly sensitive MRI of single cells and transplanted pancreatic islets. Proc Natl Acad Sci USA. 2011, 108 (7): 2662-2667. 10.1073\/pnas.1016409108.","journal-title":"Proc Natl Acad Sci USA"},{"key":"185_CR28","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1097\/00006123-199705000-00027","volume":"40","author":"J Provias","year":"1997","unstructured":"Provias J, Claffey K, DelAguila L, Nelson L, Matthias F, Abhijit G: Meningiomas: role of vascular endothelial growth factor\/vascular permeability factor in angiogenesis and peritumoral edema. Neurosurgery. 1997, 40: 1016-1026. 10.1097\/00006123-199705000-00027.","journal-title":"Neurosurgery"},{"key":"185_CR29","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nrc1041","volume":"3","author":"R Etzioni","year":"2003","unstructured":"Etzioni R, Urban N, Ramsey S, McIntosh M, Schwartz S, Reid B, Radich J, Anderson G, Hartwell L: The case for early detection. Nat Rev Cancer. 2003, 3: 243-252.","journal-title":"Nat Rev Cancer"},{"key":"185_CR30","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1227\/01.NEU.0000324896.26088.EF","volume":"63","author":"CB Stevenson","year":"2008","unstructured":"Stevenson CB, Ehtesham M, McMillan MK, Valadez JG, Edgeworth ML, Price RR, Abel TW, Mapara KY, Thompson RC: CXCR4 expression is elevated in glioblastoma multiforme and correlates with an increase in intensity and extent of peritumoral T2-weighted magnetic resonance imaging signal abnormalities. Neurosurgery. 2008, 63: 560-569. 10.1227\/01.NEU.0000324896.26088.EF.","journal-title":"Neurosurgery"},{"key":"185_CR31","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1038\/sj.onc.1209302","volume":"25","author":"M Ehtesham","year":"2006","unstructured":"Ehtesham M, Winston JA, Kabos P, Thompson RC: CXCR4 expression mediates glioma cell invasiveness. Oncogene. 2006, 25: 2801-2806. 10.1038\/sj.onc.1209302.","journal-title":"Oncogene"},{"key":"185_CR32","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/ncb1800","volume":"10","author":"J Skong","year":"2008","unstructured":"Skong J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, Curry WT, Carter BS, Krichevsky AM, Breakefield XO: Gliobliastoma microvesicles transport RNA and proteins that promote tumor growth and provide diagnostic biomarkers. Nat Cell Biol. 2008, 10: 1470-1476. 10.1038\/ncb1800.","journal-title":"Nat Cell Biol"},{"key":"185_CR33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/BF00146086","volume":"27","author":"MA Hammoud","year":"1996","unstructured":"Hammoud MA, Sawaya R, Shi W, et al: Prognostic significance of preoperative MRI scan in gliobliastoma multiforme. J Neurooncol. 1996, 27: 65-73. 10.1007\/BF00146086.","journal-title":"J Neurooncol"},{"key":"185_CR34","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00401-007-0293-7","volume":"114","author":"A Claes","year":"2007","unstructured":"Claes A, Idema AJ, Wesseling P: Diffuse glioma growth: a guerilla war. Acta Neuropathol. 2007, 114: 443-458. 10.1007\/s00401-007-0293-7.","journal-title":"Acta Neuropathol"},{"key":"185_CR35","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.addr.2004.07.015","volume":"57","author":"GM Tozer","year":"2005","unstructured":"Tozer GM, Ameer-Beg SM, Baker J, Barber PR, Hill SA, Hodgkiss RJ, Locke R, Prise VE, Wilson I, Vojnovic B: Intravital imaging of tumor vascular networks using multi-photon fluorescence microscopy. Adv Drug Deliver Rev. 2005, 57: 135-152. 10.1016\/j.addr.2004.07.015.","journal-title":"Adv Drug Deliver Rev"},{"key":"185_CR36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/BF00698288","volume":"66","author":"T Kuroiwa","year":"1985","unstructured":"Kuroiwa T, Cahn R, Juhler M, Goping G, Campbell G, Klatzo I: Role of extracellular proteins in the dynamics of vasogenic brain edema. Acta Neuropathol. 1985, 66: 3-11. 10.1007\/BF00698288.","journal-title":"Acta Neuropathol"},{"key":"185_CR37","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3171\/jns.1977.46.1.0024","volume":"46","author":"HJ Reulen","year":"1977","unstructured":"Reulen HJ, Graham R, Spatz M, Klatzo I: Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema. J Neurosurgery. 1977, 46: 24-35. 10.3171\/jns.1977.46.1.0024.","journal-title":"J Neurosurgery"},{"key":"185_CR38","doi-asserted-by":"publisher","first-page":"560","DOI":"10.3171\/jns.1994.81.4.0560","volume":"81","author":"J Strugar","year":"1994","unstructured":"Strugar J, Rothbart D, Harrington W, Criscuolo GR: Vascular permeability factor in brain metastases correlation with vasogenic brain edema and tumor angiogenesis. J Neurosurgery. 1994, 81: 560-566. 10.3171\/jns.1994.81.4.0560.","journal-title":"J Neurosurgery"},{"key":"185_CR39","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.1750-3639.2008.00136.x","volume":"18","author":"A Martin-Villalba","year":"2008","unstructured":"Martin-Villalba A, Okuducu AF, von Deimling A: The evolution of our understanding on glioma. Brain Pathol. 2008, 18: 455-463. 10.1111\/j.1750-3639.2008.00136.x.","journal-title":"Brain Pathol"},{"key":"185_CR40","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1038\/sj.bjc.6604389","volume":"98","author":"G Gambarota","year":"2008","unstructured":"Gambarota G, Leenders W, Maass C, Wesseling P, van der Kogel B, van Tellingen O, Heerschap A: Characterisation of tumor vasculature in mouse brain by USPIO contrast-enhanced MRI. Br J Cancer. 2008, 98: 1784-1789. 10.1038\/sj.bjc.6604389.","journal-title":"Br J Cancer"},{"key":"185_CR41","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1002\/mrm.1910400602","volume":"40","author":"J Dennie","year":"1998","unstructured":"Dennie J, Mandeville JB, Boxerman JL, Packard SD, Rosen BR, Weisskoff RM: NMR imaging of changes in vascular morphology due to tumor angiogenesis. Magn Reson Med. 1998, 40: 793-799. 10.1002\/mrm.1910400602.","journal-title":"Magn Reson Med"},{"key":"185_CR42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/mrm.1910310103","volume":"31","author":"RP Kennan","year":"1994","unstructured":"Kennan RP, Zhong J, Gore JC: Intravascular susceptibility contrast mechanisms in tissues. Magn Reson Med. 1994, 31: 9-21. 10.1002\/mrm.1910310103.","journal-title":"Magn Reson Med"},{"key":"185_CR43","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1148\/radiol.2512080485","volume":"251","author":"M Oostendorp","year":"2009","unstructured":"Oostendorp M, Post MJ, Backes WH: Vessel growth and function: depiction with contrast-enhanced MR imaging. Radiology. 2009, 251: 317-335. 10.1148\/radiol.2512080485.","journal-title":"Radiology"},{"key":"185_CR44","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/(SICI)1522-2586(199908)10:2<118::AID-JMRI2>3.0.CO;2-V","volume":"10","author":"W Lin","year":"1999","unstructured":"Lin W, Mukherjee P, An H, Yu Y, Wang Y, Vo K, Lee B, Kido D, Haacke EM: Improving high-resolution MR bold venographic imaging using a T1 reducing contrast agent. J Magn Reson Imag. 1999, 10: 118-123. 10.1002\/(SICI)1522-2586(199908)10:2<118::AID-JMRI2>3.0.CO;2-V.","journal-title":"J Magn Reson Imag"},{"key":"185_CR45","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/jmri.1880020415","volume":"2","author":"SN Urchuk","year":"1992","unstructured":"Urchuk SN, Plewes DB: Mechanisms of flow-induced signal loss in MR angiography. J Magn Reson Imag. 1992, 2: 453-462. 10.1002\/jmri.1880020415.","journal-title":"J Magn Reson Imag"},{"key":"185_CR46","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/mrm.1910240219","volume":"24","author":"RM Weisskoff","year":"1992","unstructured":"Weisskoff RM, Kihne S: MRI susceptometry: image-based measurement of absolute susceptibility of MR contrast agents and human blood. Magn Reson Med. 1992, 24: 375-383. 10.1002\/mrm.1910240219.","journal-title":"Magn Reson Med"},{"key":"185_CR47","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1002\/mrm.21283","volume":"58","author":"J Sedlacik","year":"2007","unstructured":"Sedlacik J, Rauscher A, Reichenbach JR: Obtaining blood oxygenation levels from MR Signal behavior in the presence of single venous vessels. Magn Reson Med. 2007, 58: 1035-1044. 10.1002\/mrm.21283.","journal-title":"Magn Reson Med"},{"key":"185_CR48","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/nbm.1581","volume":"24","author":"C Denk","year":"2011","unstructured":"Denk C, Torres EH, MacKay A, Rauscher A: The influence of white matter fibre orientation on MR signal phase and decay. NMR Biomed. 2011, 24: 246-252. 10.1002\/nbm.1581.","journal-title":"NMR Biomed"},{"key":"185_CR49","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/mrm.21754","volume":"60","author":"A Deistung","year":"2008","unstructured":"Deistung A, Rauscher A, Sedlacik J, Stadler J, Witoszynskyj S, Reichenbach JR: Susceptibility weighted imaging at ultra high magnetic field strengths: theoretical considerations and experimental results. Magn Reson Med. 2008, 60: 1155-1168. 10.1002\/mrm.21754.","journal-title":"Magn Reson Med"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2342-13-20.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2342-13-20\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2342-13-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2342-13-20.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:46:19Z","timestamp":1630543579000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/1471-2342-13-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,18]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["185"],"URL":"https:\/\/doi.org\/10.1186\/1471-2342-13-20","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,18]]},"assertion":[{"value":"18 February 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"20"}}