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Prior reports indicate a significant normal aging effect on serotonin 5HT<jats:sub>2A<\/jats:sub>receptor (5HT<jats:sub>2A<\/jats:sub>R) binding potential. The purpose of this study was to assess the test-retest variability of [<jats:sup>18<\/jats:sup>F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT<jats:sub>2A<\/jats:sub>R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65\u201378 years) completed two [<jats:sup>18<\/jats:sup>F]-setoperone PET scans on two separate occasions 5\u201316 weeks apart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average difference in the binding potential (BP<jats:sub>ND<\/jats:sub>) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that the test-retest variability of [<jats:sup>18<\/jats:sup>F]-setoperone PET in elderly subjects is comparable to that of [<jats:sup>18<\/jats:sup>F]-setoperone and other 5HT<jats:sub>2A<\/jats:sub>R radiotracers in younger subject samples.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2342-9-12","type":"journal-article","created":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T06:15:02Z","timestamp":1246947302000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults"],"prefix":"10.1186","volume":"9","author":[{"given":"Tiffany W","family":"Chow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C","family":"Mamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Graff-Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Houle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwenn S","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce G","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit H","family":"Mulsant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,7,6]]},"reference":[{"issue":"11","key":"70_CR1","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1001\/archinte.165.11.1280","volume":"165","author":"BA Briesacher","year":"2005","unstructured":"Briesacher BA, Limcangco MR, Simoni-Wastila L, Doshi JA, Levens SR, Shea DG, Stuart B: The quality of antipsychotic drug prescribing in nursing homes. 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