{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:31:32Z","timestamp":1783434692891,"version":"3.54.6"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T00:00:00Z","timestamp":1239148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genet"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Polymorphisms of the prion protein gene (<jats:italic>PRNP<\/jats:italic> ) at codons 129 and 219 play an important role in the susceptibility to Creutzfeldt-Jakob disease (CJD), and might be associated with other neurodegenerative disorders. Several recent reports indicate that polymorphisms outside the coding region of <jats:italic>PRNP<\/jats:italic> modulate the expression of prion protein and are associated with sporadic CJD, although other studies failed to show an association. These reports involved the polymorphism <jats:italic>PRNP<\/jats:italic> 1368 which is located upstream from <jats:italic>PRNP<\/jats:italic> exon 1. In a case-controlled protocol, we assessed the possible association between the <jats:italic>PRNP<\/jats:italic> 1368 polymorphism and either Alzheimer's disease (AD) or vascular dementia (VaD).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>To investigate whether the <jats:italic>PRNP<\/jats:italic> 1368 polymorphism is associated with the occurrence of AD or VaD in the Korean population, we compared the genotype, allele, and haplotype frequencies of the <jats:italic>PRNP<\/jats:italic> 1368 polymorphism in 152 AD patients and 192 VaD patients with frequencies in 268 healthy Koreans.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results and conclusion<\/jats:title>\n            <jats:p>Significant differences in genotype, allele and haplotype frequencies of <jats:italic>PRNP<\/jats:italic> 1368 polymorphism were not observed between AD and normal controls. There were no significant differences in the genotype and allele frequencies of the <jats:italic>PRNP<\/jats:italic> 1368 polymorphism between Korean VaD patients and normal controls. However, in the haplotype analysis, haplotype Ht5 was significantly over-represented in Korean VaD patients. This was the first genetic association study of a polymorphism outside the coding region of <jats:italic>PRNP<\/jats:italic> in relation to AD and VaD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2350-10-32","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T06:13:20Z","timestamp":1239171200000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lack of association between PRNP 1368 polymorphism and Alzheimer's disease or vascular dementia"],"prefix":"10.1186","volume":"10","author":[{"given":"Byung-Hoon","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Joong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Kyoung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Sook","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I","family":"Carp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,4,8]]},"reference":[{"key":"446_CR1","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1172\/JCI24761","volume":"115","author":"L Bertram","year":"2005","unstructured":"Bertram L, Tanzi RE: The genetic epidemiology of neurodegenerative disease. J Clin Invest. 2005, 115: 1449-1457. 10.1172\/JCI24761.","journal-title":"J Clin Invest"},{"key":"446_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1046\/j.1365-2990.2000.00239.x","volume":"26","author":"MM Esiri","year":"2000","unstructured":"Esiri MM, Carter J, Ironside JW: Prion protein immunoreactivity in brain samples from an unselected autopsy population: findings in 200 consecutive cases. Neuropathol Appl Neurobiol. 2000, 26: 273-284. 10.1046\/j.1365-2990.2000.00239.x.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"446_CR3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s004010000271","volume":"101","author":"I Ferrer","year":"2001","unstructured":"Ferrer I, Blanco R, Carmona M, Puig B, Ribera R, Rey MJ, Ribalta T: Prion protein expression in senile plaques in Alzheimer's disease. Acta Neuropathologica. 2001, 101: 49-56.","journal-title":"Acta Neuropathologica"},{"key":"446_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1750-3639.2002.tb00417.x","volume":"12","author":"GG Kov\u00e1cs","year":"2002","unstructured":"Kov\u00e1cs GG, Head MW, Hegyi I, Bunn TJ, Flicker H, Hainfellner JA, McCardle L, L\u00e1szl\u00f3 L, Jarius C, Ironside JW, Budka H: Immunohistochemistry for the prion protein: comparison of different monoclonal antibodies in human prion disease subtypes. Brain Pathol. 2002, 12: 1-11.","journal-title":"Brain Pathol"},{"key":"446_CR5","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s004010050870","volume":"96","author":"JA Hainfellner","year":"1998","unstructured":"Hainfellner JA, Wanschitz J, Jellinger K, Liberski PP, Gullotta F, Budka H: Coexistence of Alzheimer-type neuropathology in Creutzfeldt-Jakob disease. Acta Neuropathol. 1998, 96: 116-122. 10.1007\/s004010050870.","journal-title":"Acta Neuropathol"},{"key":"446_CR6","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/sj.ejhg.5201544","volume":"14","author":"S Mead","year":"2006","unstructured":"Mead S: Prion disease genetics. Eur J Hum Genet. 2006, 14: 273-281. 10.1038\/sj.ejhg.5201544.","journal-title":"Eur J Hum Genet"},{"key":"446_CR7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s00439-005-0020-1","volume":"118","author":"GG Kovacs","year":"2005","unstructured":"Kovacs GG, Puopolo M, Ladogana A, Pocchiari M, Budka H, van Duijn C, Collins SJ, Boyd A, Giulivi A, Coulthart M, Delasnerie-Laupretre N, Brandel JP, Zerr I, Kretzschmar HA, de Pedro-Cuesta J, Calero-Lara M, Glatzel M, Aguzzi A, Bishop M, Knight R, Belay G, Will R, Mitrova E, EUROCJD: Genetic prion disease: the EUROCJD experience. Hum Genet. 2005, 118: 166-174. 10.1007\/s00439-005-0020-1.","journal-title":"Hum Genet"},{"key":"446_CR8","first-page":"888","volume":"58","author":"R Petraroli","year":"1996","unstructured":"Petraroli R, Pocchiari M: Codon 219 polymorphism of PRNP in healthy Caucasians and Creutzfeldt-Jakob disease patients. Am J Hum Genet. 1996, 58: 888-889.","journal-title":"Am J Hum Genet"},{"key":"446_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s10048-005-0016-y","volume":"6","author":"BH Jeong","year":"2005","unstructured":"Jeong BH, Lee KH, Kim NH, Jin JK, Kim JI, Carp RI, Kim YS: Association of sporadic Creutzfeldt-Jakob disease with homozygous genotypes at PRNP codons 129 and 219 in the Korean population. Neurogenetics. 2005, 6: 229-232. 10.1007\/s10048-005-0016-y.","journal-title":"Neurogenetics"},{"key":"446_CR10","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/352340a0","volume":"352","author":"MS Palmer","year":"1991","unstructured":"Palmer MS, Dryden AJ, Hughes JT, Collinge J: Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease. Nature. 1991, 352: 340-342. 10.1038\/352340a0.","journal-title":"Nature"},{"key":"446_CR11","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/ana.410430618","volume":"43","author":"S Shibuya","year":"1998","unstructured":"Shibuya S, Higuchi J, Shin RW, Tateishi J, Kitamoto T: Codon 219 Lys allele of PRNP is not found in sporadic Creutzfeldt-Jakob disease. Ann Neurol. 1998, 43: 826-828. 10.1002\/ana.410430618.","journal-title":"Ann Neurol"},{"key":"446_CR12","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/ana.10507","volume":"53","author":"B Dermaut","year":"2003","unstructured":"Dermaut B, Croes EA, Rademakers R, Broeck Van den M, Cruts M, Hofman A, van Duijn CM, Van Broeckhoven C: PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. Ann Neurol. 2003, 53: 409-412. 10.1002\/ana.10507.","journal-title":"Ann Neurol"},{"key":"446_CR13","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1007\/s00702-006-0540-4","volume":"113","author":"M Gacia","year":"2006","unstructured":"Gacia M, Safranow K, Styczy\u00f1ska M, Jakubowska K, Pep\u0142o\u00f1ska B, Chodakowska-Zebrowska M, Przekop I, S\u0142owik A, Gola\u00f1ska E, Hu\u0142as-Bigoszewska K, Chlubek D, Religa D, Zekanowski C, Barcikowska M: Prion protein gene M129 allele is a risk factor for Alzheimer's disease. J Neural Transm. 2006, 113: 1747-1751. 10.1007\/s00702-006-0540-4.","journal-title":"J Neural Transm"},{"key":"446_CR14","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1212\/01.WNL.0000103290.74549.DC","volume":"62","author":"E Golanska","year":"2004","unstructured":"Golanska E, Hulas-Bigoszewska K, Rutkiewicz E, Styczynska M, Peplonska B, Barcikowska M, Bratosiewicz-Wasik J, Liberski PP: Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD. Neurology. 2004, 62: 313-315.","journal-title":"Neurology"},{"key":"446_CR15","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1212\/01.WNL.0000130198.72589.69","volume":"63","author":"M Riemenschneider","year":"2004","unstructured":"Riemenschneider M, Klopp N, Xiang W, Wagenpfeil S, Vollmert C, Muller U, Forstl H, Illig T, Kretzschmar H, Kurz A: Prion protein codon 129 polymorphism and risk of Alzheimer disease. Neurology. 2004, 63: 364-366.","journal-title":"Neurology"},{"key":"446_CR16","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1136\/jnnp.71.2.279","volume":"71","author":"VM Casadei","year":"2001","unstructured":"Casadei VM, Ferri C, Calabrese E, Grimaldi LM, Franceschi M, Veglia F, Licastro F, Mariani C: Prion protein gene polymorphism and Alzheimer's disease: one modulatory trait of cognitive decline?. J Neurol Neurosurg Psychiatry. 2001, 71: 279-280. 10.1136\/jnnp.71.2.279.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"446_CR17","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1212\/WNL.55.4.593","volume":"55","author":"O Combarros","year":"2000","unstructured":"Combarros O, S\u00e1nchez-Guerra M, Llorca J, Alvarez-Arcaya A, Berciano J, Pe\u00f1a N, Fern\u00e1ndez-Viadero C: Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD. Neurology. 2000, 55: 593-595.","journal-title":"Neurology"},{"key":"446_CR18","doi-asserted-by":"publisher","first-page":"770e1","DOI":"10.1016\/j.neurobiolaging.2005.05.025","volume":"27","author":"R Del Bo","year":"2006","unstructured":"Del Bo R, Scarlato M, Ghezzi S, Martinelli-Boneschi F, Fenoglio C, Galimberti G, Galbiati S, Virgilio R, Galimberti D, Ferrarese C, Scarpini E, Bresolin N, Comi GP: Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis. Neurobiol Aging. 2006, 27: 770e1-770.e5.","journal-title":"Neurobiol Aging"},{"key":"446_CR19","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/ana.10748","volume":"54","author":"T Ohkubo","year":"2003","unstructured":"Ohkubo T, Sakasegawa Y, Asada T, Kinoshita T, Goto Y, Kimura H, Mizusawa H, Hachiya NS, Kaneko K: Absence of association between codon 129\/219 polymorphisms of the prion protein gene and Alzheimer's disease in Japan. Ann Neurol. 2003, 54: 553-554. 10.1002\/ana.10748.","journal-title":"Ann Neurol"},{"key":"446_CR20","doi-asserted-by":"publisher","first-page":"e53","DOI":"10.1136\/jmg.2006.040931","volume":"43","author":"C Vollmert","year":"2006","unstructured":"Vollmert C, Windl O, Xiang W, Rosenberger A, Zerr I, Wichmann HE, Bickeb\u00f6ller H, Illig T, KORA group, Kretzschmar HA: Significant association of a M129V independent polymorphism in the 5' UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study. J Med Genet. 2006, 43: e53-10.1136\/jmg.2006.040931.","journal-title":"J Med Genet"},{"key":"446_CR21","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1086\/324710","volume":"69","author":"S Mead","year":"2001","unstructured":"Mead S, Mahal SP, Beck J, Campbell T, Farrall M, Fisher E, Collinge J: Sporadic\u2013but not variant\u2013Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1. Am J Hum Genet. 2001, 69: 1225-1235. 10.1086\/324710.","journal-title":"Am J Hum Genet"},{"key":"446_CR22","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/sj.ejhg.5201161","volume":"12","author":"EA Croes","year":"2004","unstructured":"Croes EA, Alizadeh BZ, Bertoli-Avella AM, Rademaker T, Vergeer-Drop J, Dermaut B, Houwing-Duistermaat JJ, Wientjens DP, Hofman A, Van Broeckhoven C, van Duijn CM: Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease. Eur J Hum Genet. 2004, 12: 389-394. 10.1038\/sj.ejhg.5201161.","journal-title":"Eur J Hum Genet"},{"key":"446_CR23","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/j.1468-1331.2008.02203.x","volume":"15","author":"BH Jeong","year":"2008","unstructured":"Jeong BH, Lee KH, Lee YJ, Kim YH, Cho YS, Carp RI, Kim YS: PRNP 1368 polymorphism is not associated with sporadic Creutzfeldt-Jakob disease in the Korean population. Eur J Neurol. 2008, 15: 846-850. 10.1111\/j.1468-1331.2008.02203.x.","journal-title":"Eur J Neurol"},{"key":"446_CR24","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/ana.20931","volume":"60","author":"JD Rohrer","year":"2006","unstructured":"Rohrer JD, Mead S, Omar R, Poulter M, Warren JD, Collinge J, Rossor MN: Prion protein (PRNP) genotypes in frontotemporal lobar degeneration syndromes. Ann Neurol. 2006, 60: 616-10.1002\/ana.20931.","journal-title":"Ann Neurol"},{"key":"446_CR25","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984, 34: 939-944.","journal-title":"Neurology"},{"key":"446_CR26","unstructured":"American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders. 1994, (DSM-IV), Washington, DC, 143-147. Fourth"},{"key":"446_CR27","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1212\/WNL.43.2.250","volume":"43","author":"GC Roman","year":"1993","unstructured":"Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A, Moody DM, O'Brien MD, Yamaguchi T, Grafman J, Drayer BP, Bennett DA, Fisher M, Ogata J, Kokmen E, Bermejo F, Wolf PA, Gorelick PB, Bick KL, Pajeau AK, Bell MA, DeCarli C, Culebras A, Korczyn AD, Bogousslavsky J, Hartmann A, Scheinberg P: Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology. 1993, 43: 250-260.","journal-title":"Neurology"},{"key":"446_CR28","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1086\/319501","volume":"68","author":"M Stephens","year":"2001","unstructured":"Stephens M, Smith NJ, Donnelly P: A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 2001, 68: 978-989. 10.1086\/319501.","journal-title":"Am J Hum Genet"},{"key":"446_CR29","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s10038-004-0150-7","volume":"49","author":"BH Jeong","year":"2004","unstructured":"Jeong BH, Nam JH, Lee YJ, Lee KH, Jang MK, Carp RI, Lee HD, Ju YR, Jo SA, Park KY, Kim YS: Polymorphisms of the prion protein gene (PRNP) in a Korean population. J Hum Genet. 2004, 49: 319-324. 10.1007\/s10038-004-0150-7.","journal-title":"J Hum Genet"},{"key":"446_CR30","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/j.1468-1331.2007.01786.x","volume":"14","author":"BH Jeong","year":"2007","unstructured":"Jeong BH, Lee KH, Jeong YE, Hwang KA, Lee YJ, Carp RI, Ju YR, Kim YS: Polymorphisms at codons 129 and 219 of the prion protein gene (PRNP) are not associated with sporadic Alzheimer's disease in the Korean population. Eur J Neurol. 2007, 14: 621-626. 10.1111\/j.1468-1331.2007.01786.x.","journal-title":"Eur J Neurol"},{"key":"446_CR31","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1159\/000103913","volume":"24","author":"BH Jeong","year":"2007","unstructured":"Jeong BH, Na HR, Bae JC, Lee KH, Lee YJ, Kim NH, Song JH, Carp RI, Kim YS: Absence of association between codon 129 and 219 polymorphisms of the prion protein gene and vascular dementia. Dement Geriatr Cogn Disord. 2007, 24: 86-90. 10.1159\/000103913.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"446_CR32","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1139\/g06-110","volume":"49","author":"BH Jeong","year":"2006","unstructured":"Jeong BH, Lee YJ, Kim NH, Carp RI, Kim YS: Genotype distribution of the prion protein gene (PRNP) promoter polymorphisms in Korean cattle. Genome. 2006, 49: 1539-1544. 10.1139\/G06-110.","journal-title":"Genome"},{"key":"446_CR33","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1096\/fj.06-7522com","volume":"21","author":"K Kashkevich","year":"2007","unstructured":"Kashkevich K, Humeny A, Ziegler U, Groschup MH, Nicken P, Leeb T, Fischer C, Becker CM, Schiebel K: Functional relevance of DNA polymorphisms within the promoter region of the prion protein gene and their association to BSE infection. FASEB J. 2007, 21: 1547-1555. 10.1096\/fj.06-7522com.","journal-title":"FASEB J"},{"key":"446_CR34","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1266\/ggs.80.303","volume":"80","author":"BH Jeong","year":"2005","unstructured":"Jeong BH, Sohn HJ, Lee JO, Kim NH, Kim JI, Lee SY, Cho IS, Joo YS, Carp RI, Kim YS: Polymorphisms of the prion protein gene (PRNP) in Hanwoo (Bos taurus coreanae) and Holstein cattle. Genes Genet Syst. 2005, 80: 303-308. 10.1266\/ggs.80.303.","journal-title":"Genes Genet Syst"},{"key":"446_CR35","doi-asserted-by":"publisher","first-page":"37408","DOI":"10.1074\/jbc.M506361200","volume":"280","author":"P Sander","year":"2005","unstructured":"Sander P, Hamann H, Dr\u00f6gem\u00fcller C, Kashkevich K, Schiebel K, Leeb T: Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibility. J Biol Chem. 2005, 280: 37408-37414. 10.1074\/jbc.M506361200.","journal-title":"J Biol Chem"},{"key":"446_CR36","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/0092-8674(93)90360-3","volume":"73","author":"H Bueler","year":"1993","unstructured":"Bueler H, Aguzzi A, Sailer A, Greiner RA, Autenried P, Aguet M, Weissmann C: Mice devoid of PrP are resistant to scrapie. Cell. 1993, 73: 1339-1347. 10.1016\/0092-8674(93)90360-3.","journal-title":"Cell"},{"key":"446_CR37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0896-6273(91)90074-A","volume":"7","author":"D Westaway","year":"1991","unstructured":"Westaway D, Mirenda CA, Foster D, Zebarjadian Y, Scott M, Torchia M, Yang SL, Serban H, DeArmond SJ, Ebeling C, Prusiner SB, Carlson GA: Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice. Neuron. 1991, 7: 59-68. 10.1016\/0896-6273(91)90074-A.","journal-title":"Neuron"},{"key":"446_CR38","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0378-1119(02)00466-3","volume":"288","author":"JE McCormack","year":"2002","unstructured":"McCormack JE, Baybutt HN, Everington D, Will RG, Ironside JW, Manson JC: PRNP contains both intronic and upstream regulatory regions that may influence susceptibility to Creutzfeldt-Jakob Disease. Gene. 2002, 288: 139-146. 10.1016\/S0378-1119(02)00466-3.","journal-title":"Gene"},{"key":"446_CR39","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.neulet.2006.08.001","volume":"411","author":"J Bratosiewicz-Wasik","year":"2007","unstructured":"Bratosiewicz-Wasik J, Liberski PP, Golanska E, Jansen GH, Wasik TJ: Regulatory sequences of the PRNP gene influence susceptibility to sporadic Creutzfeldt-Jakob disease. Neurosci Lett. 2007, 411: 163-167. 10.1016\/j.neulet.2006.08.001.","journal-title":"Neurosci Lett"}],"container-title":["BMC Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-10-32.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2350-10-32\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-10-32","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-10-32.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:35:32Z","timestamp":1630456532000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedgenet.biomedcentral.com\/articles\/10.1186\/1471-2350-10-32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,8]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["446"],"URL":"https:\/\/doi.org\/10.1186\/1471-2350-10-32","relation":{},"ISSN":["1471-2350"],"issn-type":[{"value":"1471-2350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,8]]},"assertion":[{"value":"29 August 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"32"}}