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Most studies undertaken to date were under-powered, and none has been replicated within a population. Association with tuberculosis has replicated variably across populations. Here we investigate<jats:italic>SLC11A1<\/jats:italic>and VL in India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine polymorphisms (rs34448891, rs7573065, rs2276631, rs3731865, rs17221959, rs2279015, rs17235409, rs17235416, rs17229009) that tag linkage disequilibrium blocks across<jats:italic>SLC11A1<\/jats:italic>were genotyped in primary family-based (313 cases; 176 families) and replication (941 cases; 992 controls) samples. Family- and population-based analyses were performed to look for association between<jats:italic>SLC11A1<\/jats:italic>variants and VL. Quantitative RT\/PCR was used to compare SLC11A1 expression in mRNA from paired splenic aspirates taken before and after treatment from 24 VL patients carrying different genotypes at the functional promoter GT<jats:sub>n<\/jats:sub>polymorphism (rs34448891).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No associations were observed between VL and polymorphisms at<jats:italic>SLC11A1<\/jats:italic>that were either robust to correction for multiple testing or replicated across primary and replication samples. No differences in expression of SLC11A1 were observed when comparing pre- and post-treatment samples, or between individuals carrying different genotypes at the GT<jats:sub>n<\/jats:sub>repeat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first well-powered study of<jats:italic>SLC11A1<\/jats:italic>as a candidate for VL, which we conclude does not have a major role in regulating VL susceptibility in India.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2350-12-71","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T06:21:02Z","timestamp":1309933262000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["No evidence for association between SLC11A1and visceral leishmaniasis in India"],"prefix":"10.1186","volume":"12","author":[{"given":"Sanjana","family":"Mehrotra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Oommen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshuman","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medhavi","family":"Sudharshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja","family":"Tiwary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarra E","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Fakiola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa Selvi","family":"Rani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumarasamy","family":"Thangaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhukar","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Sundar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenefer M","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,5,20]]},"reference":[{"issue":"3","key":"812_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0035-9203(01)90223-8","volume":"95","author":"P Desjeux","year":"2001","unstructured":"Desjeux P: The increase in risk factors for leishmaniasis worldwide. 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