{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:24:22Z","timestamp":1783056262273,"version":"3.54.6"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T00:00:00Z","timestamp":1325635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genet"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Since subepithelial fibrosis and protruded extracellular matrix are among the histological characteristics of polyps, the <jats:italic>emilin\/multimerin domain-containing protein 2<\/jats:italic> (<jats:italic>EMID2<\/jats:italic>) gene is speculated to be involved in the presence of nasal polyps in asthma and aspirin-hypersensitive patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>To investigate the association between <jats:italic>EMID2<\/jats:italic> and nasal polyposis, 49 single-nucleotide polymorphisms (SNPs) were genotyped in 467 asthmatics of Korean ancestry who were stratified further into 114 aspirin exacerbated respiratory disease (AERD) and 353 aspirin-tolerant asthma (ATA) subgroups. From pairwise comparison of the genotyped polymorphisms, 14 major haplotypes (frequency &gt; 0.05) were inferred and selected for association analysis. Differences in the frequency distribution of <jats:italic>EMID2<\/jats:italic> variations between polyp-positive cases and polyp-negative controls were determined using logistic analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Initially, 13 <jats:italic>EMID2<\/jats:italic> variants were significantly associated with the presence of nasal polyps in the overall asthma group (<jats:italic>P<\/jats:italic> = 0.0008-0.05, OR = 0.54-1.32 using various modes of genetic inheritance). Although association signals from 12 variants disappeared after multiple testing corrections, the relationship between <jats:italic>EMID2_BL1_ht2<\/jats:italic> and nasal polyposis remained significant via a codominant mechanism (<jats:italic>P<\/jats:italic>\n              <jats:sup>\n                <jats:italic>corr<\/jats:italic>\n              <\/jats:sup> = 0.03). On the other hand, the nominal associations observed between the genetic variants tested for the presence of nasal polyps in AERD (<jats:italic>P<\/jats:italic> = 0.003-0.05, OR = 0.25-1.82) and ATA (<jats:italic>P<\/jats:italic> = 0.01-0.04, OR = 0.46-10.96) subgroups disappeared after multiple comparisons, suggesting lack of associations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These preliminary findings suggest that <jats:italic>EMID2_BL1_ht2<\/jats:italic> may be a susceptibility marker of inflammation of the nasal passages among Korean asthma patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2350-13-2","type":"journal-article","created":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T07:44:05Z","timestamp":1325749445000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients"],"prefix":"10.1186","volume":"13","author":[{"given":"Charisse Flerida Arnejo","family":"Pasaje","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Seol","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Lae","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Sub","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Soo","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Taek","family":"Uh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon-Sik","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Doo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,4]]},"reference":[{"issue":"1-2","key":"912_CR1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3109\/00016488709134709","volume":"103","author":"H Kakoi","year":"1987","unstructured":"Kakoi H, Hiraide F: A histological study of formation and growth of nasal polyps. 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