{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:44:01Z","timestamp":1778960641233,"version":"3.51.4"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,1,15]],"date-time":"2003-01-15T00:00:00Z","timestamp":1042588800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genet"],"DOI":"10.1186\/1471-2350-4-1","type":"journal-article","created":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T12:27:54Z","timestamp":1051792074000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Frequency of CHEK2*1100delC in New York breast cancer cases and controls"],"prefix":"10.1186","volume":"4","author":[{"given":"Kenneth","family":"Offit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Kirchhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prema","family":"Kolachana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Rapaport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gregersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Yossepowitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Satagopan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Robson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Scheuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khedoudja","family":"Nafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,1,15]]},"reference":[{"key":"27_CR1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1101\/gad.14.3.278","volume":"14","author":"NH Chehab","year":"2000","unstructured":"Chehab NH, Malikzay A, Appel M, Halazonetis TD: Chk2\/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 2000, 14: 278-288.","journal-title":"Genes Dev"},{"key":"27_CR2","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/35004614","volume":"404","author":"JS Lee","year":"2000","unstructured":"Lee JS, Collins KM, Brown AL, Lee CH, Chung JH: hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature. 2000, 404: 201-204. 10.1038\/35004614.","journal-title":"Nature"},{"key":"27_CR3","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1126\/science.286.5449.2528","volume":"286","author":"DW Bell","year":"1999","unstructured":"Bell DW, Varley JM, Szydlo TE, Kang DH, Wahrer DC, Shannon KE, et al: Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science. 1999, 286: 2528-2523. 10.1126\/science.286.5449.2528.","journal-title":"Science"},{"key":"27_CR4","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1086\/341943","volume":"71","author":"P Vahteristo","year":"2002","unstructured":"Vahteristo P, Bartkova J, Eerola H, Syrjakoski K, Ojala S, Kilpivaara O, et al: CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast Cancer. Am J Hum Genet. 2002, 71: 432-438. 10.1086\/341943.","journal-title":"Am J Hum Genet"},{"key":"27_CR5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ng879","volume":"31","author":"The CHEK2 Breast Cancer Consortium","year":"2002","unstructured":"The CHEK2 Breast Cancer Consortium: Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nature Genet. 2002, 31: 55-59. 10.1038\/ng879.","journal-title":"Nature Genet"},{"key":"27_CR6","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1136\/jmg.39.8.611","volume":"39","author":"N Kauff","year":"2002","unstructured":"Kauff N, Perez-Segura P, Robson M, Scheuer L, Siegel B, Schluger A, et al: Incidence of non-founder BRCA1 and BRCA2 mutations in high-risk Ashkenazi breast and ovarian cancer families. J Medical Genet. 2002, 39: 611-614. 10.1136\/jmg.39.8.611.","journal-title":"J Medical Genet"},{"key":"27_CR7","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1054\/bjoc.2001.1858","volume":"85","author":"M Allinen","year":"2001","unstructured":"Allinen M, Huusko P, Mantyniemi S, Launonen V, Winqvist R: Mutation analysis of the CHK2 gene in families with hereditary breast cancer. Br J Cancer. 2001, 85: 209-212. 10.1054\/bjoc.2001.1858.","journal-title":"Br J Cancer"},{"key":"27_CR8","first-page":"99","volume":"6","author":"CB Begg","year":"1997","unstructured":"Begg CB, Berwick M: A note on the estimation of relative risks of rare genetic susceptibility markers. Cancer Epidemiol Biomarkers Prev. 1997, 6: 99-103.","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["BMC Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-4-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2350-4-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-4-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-4-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T15:41:40Z","timestamp":1726242100000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedgenet.biomedcentral.com\/articles\/10.1186\/1471-2350-4-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,15]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,12]]}},"alternative-id":["27"],"URL":"https:\/\/doi.org\/10.1186\/1471-2350-4-1","relation":{},"ISSN":["1471-2350"],"issn-type":[{"value":"1471-2350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,15]]},"assertion":[{"value":"17 October 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2003","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2003","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"1"}}